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Bioengineering
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Nanomedicine and Brain Diseases: A Themed Focus on Nano-Engineering Methods...
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Nanomedicine and Brain Diseases: A Themed Focus on Nano-Engineering Methods for Blood–Brain Barrier Crossing/Circumventing

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3722

Special Issue Editors

Dr. Atefeh Zarepour

E-Mail Website
Guest Editor
Biomedical Engineering Department, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey
Interests: nanomedicine; theranpstics; diagnosis; therapy; drug delivery systems
Dr. Ali Zarrabi

E-Mail Website
Guest Editor
Biomedical Engineering Department, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey
Interests: nanomedicine; theranpstics; diagnosis; therapy; drug delivery systems; cancer; neurodegenerative disease; miRNA; siRNA; wound healing; biomedical engineering; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurological disorders are one of the main challenges of medical technology that affect millions of people each year and cost billions of dollars for their treatment. They span from neurodegenerative disorders to brain cancers, depression, stroke, etc. Despite the introduction of various therapeutic compounds, there is still no effective method to treat these diseases. One of the main reasons behind this ineffectiveness is the presence of a natural protecting system around the brain, known as the blood–brain barrier (BBB), which acts as brain protection against foreign substances such as bacteria, viruses, and even drugs. With the emergence of nanotechnology, researchers have benefited from nano-size features and designed nano-platforms capable of overcoming the barrier effect of the BBB, transferring drugs to the brain and improving their effectiveness. These strategies could be divided into two main categories, invasive and non-invasive methods, in accordance with the severe effects they may have on the BBB.

Based on the above, this themed issue aims to provide a panel on “Overcoming/Circumventing the BBB” utilizing different strategies in which nanomaterials have a special role. We welcome your contributions in this Special Issue in the form research papers, review articles, and communication reports on, but not limited to, the topics outlined in the keywords.

Dr. Atefeh Zarepour
Dr. Ali Zarrabi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • neurological disorders
  • blood–brain barrier
  • nose-to-brain
  • nano-engineering
  • invasive
  • non-invasive
  • targeted delivery
  • nano-platforms
  • Alzheimer
  • Parkinson
  • glioblastoma multiforme
  • glioma
  • dementia
  • cancer

Published Papers (2 papers)

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Research

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20 pages, 4185 KiB  
Article
Electroconductive Nanofibrous Scaffolds Enable Neuronal Differentiation in Response to Electrical Stimulation without Exogenous Inducing Factors
by Nika Ranjbar, Behnaz Bakhshandeh and Cristian Pablo Pennisi
Bioengineering 2023, 10(12), 1438; https://doi.org/10.3390/bioengineering10121438 - 18 Dec 2023
Cited by 1 | Viewed by 1109
Abstract
Among the various biochemical and biophysical inducers for neural regeneration, electrical stimulation (ES) has recently attracted considerable attention as an efficient means to induce neuronal differentiation in tissue engineering approaches. The aim of this in vitro study was to develop a nanofibrous scaffold [...] Read more.
Among the various biochemical and biophysical inducers for neural regeneration, electrical stimulation (ES) has recently attracted considerable attention as an efficient means to induce neuronal differentiation in tissue engineering approaches. The aim of this in vitro study was to develop a nanofibrous scaffold that enables ES-mediated neuronal differentiation in the absence of exogenous soluble inducers. A nanofibrous scaffold composed of polycaprolactone (PCL), poly-L-lactic acid (PLLA), and single-walled nanotubes (SWNTs) was fabricated via electrospinning and its physicochemical properties were investigated. The cytocompatibility of the electrospun composite with the PC12 cell line and bone marrow-derived mesenchymal stem cells (BMSCs) was investigated. The results showed that the PCL/PLLA/SWNT nanofibrous scaffold did not exhibit cytotoxicity and supported cell attachment, spreading, and proliferation. ES was applied to cells cultured on the nanofibrous scaffolds at different intensities and the expression of the three neural markers (Nestin, Microtubule-associated protein 2, and β tubulin-3) was evaluated using RT-qPCR analysis. The results showed that the highest expression of neural markers could be achieved at an electric field intensity of 200 mV/cm, suggesting that the scaffold in combination with ES can be an efficient tool to accelerate neural differentiation in the absence of exogenous soluble inducers. This has important implications for the regeneration of nerve injuries and may provide insights for further investigations of the mechanisms underlying ES-mediated neuronal commitment. Full article
(This article belongs to the Special Issue Nanomedicine and Brain Diseases: A Themed Focus on Nano-Engineering Methods for Blood–Brain Barrier Crossing/Circumventing)
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Review

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26 pages, 848 KiB  
Review
Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview
by Nathalie Okdeh, Georges Mahfouz, Julien Harb, Jean-Marc Sabatier, Rabih Roufayel, Eddie Gazo Hanna, Hervé Kovacic and Ziad Fajloun
Bioengineering 2023, 10(2), 258; https://doi.org/10.3390/bioengineering10020258 - 16 Feb 2023
Cited by 4 | Viewed by 2168
Abstract
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected. It has been demonstrated that neuropeptides can influence behavior, emotional reactions, and behavioral [...] Read more.
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected. It has been demonstrated that neuropeptides can influence behavior, emotional reactions, and behavioral disorders. This review highlights the majority of the findings demonstrating neuropeptides’ behavioral role and functional engineering in depression and anxiety. Gut–brain peptides, hypothalamic releasing hormone peptides, opioid peptides, and pituitary hormone peptides are the four major groups of neuropeptides discussed. Some neuropeptides appear to promote depression and anxiety-like symptoms, whereas others seem to reduce it, all depending on the receptors they are acting on and on the brain region they are localized in. The data supplied here are an excellent starting point for future therapy interventions aimed at treating anxiety and depression. Full article
(This article belongs to the Special Issue Nanomedicine and Brain Diseases: A Themed Focus on Nano-Engineering Methods for Blood–Brain Barrier Crossing/Circumventing)
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