Recent Advances in the Treatment of Hearing Loss

A special issue of Audiology Research (ISSN 2039-4349).

Deadline for manuscript submissions: closed (12 December 2022) | Viewed by 2472

Special Issue Editors


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Guest Editor
School of Surgery, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
Interests: hearing loss; hearing therapeutics; hearing implantation; otology and neurotology; cochlear and middle ear surgery

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Guest Editor
Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Kent St, Bentley WA 6102, Australia
Interests: cochlear physiology; preclinical animal models of hearing loss

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Guest Editor
Biotechnology and Drug Development Research Laboratory, Curtin Medical School & Curtin Health Innovation Research Institute, Curtin University, Kent St, Bentley, WA 6102, Australia
Interests: bile acid nanotechnology; PK/PD; biomaterials; drug commercialization
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Special Issue Information

Dear Colleagues,

Hearing loss is an enormous global health challenge which continues to evade mainstream drug therapeutics. Hearing loss can be caused by a variety of factors such as aging, chronic ear disease, diabetes, drugs (ototoxocity) and noise. Other common causes include hereditary (genetic) and trauma. Despite advances in hearing aid technology and implantable hearing device surgery, the fundamental treatment of the variety of hearing loss causes remains elusive. The design and development of novel therapeutics to treat hearing loss continues to challenge researchers largely due to the dual difficulty of access to the cochlea and delivery of therapeutics to end organ cellular structures within the inner ear itself. Recently, advances in inner ear drug delivery and the development of  novel bio-nanotechnologies have gained widespread interest through the promise of more efficient drug delivery to their cellular targets within the inner ear.

This special issue will explore novel treatment strategies and technologies  which can offer new therapeutic options for patients with hearing loss from a variety of causes. We especially encourage submissions concerning basic research as well as applied research in both animal and human subjects.

Dr. Jafri Kuthubutheen
Dr. Daniel Brown
Dr. Hani Al-Salami
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Audiology Research is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hearing loss
  • Bio-nanotechnologies
  • Cochlear-specific drug targeting
  • Bile acids Permeation enhancers
  • Hearing loss detection

Published Papers (1 paper)

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Research

9 pages, 1577 KiB  
Article
Evaluation of the Recovery of Idiopathic Sudden Sensorineural Hearing Loss Based on Estimated Hearing Disorders
by Tadashi Nishimura, Tadao Okayasu, Chihiro Morimoto, Sakie Akasaka, Tadashi Kitahara and Hiroshi Hosoi
Audiol. Res. 2022, 12(5), 476-484; https://doi.org/10.3390/audiolres12050048 - 01 Sep 2022
Cited by 1 | Viewed by 1875
Abstract
Various prognostic factors for idiopathic sudden sensorineural hearing loss (SSNHL) have been reported. Hearing loss directly derived from idiopathic SSNHL is important for understanding underlying pathogenesis and outcomes. We assessed the usefulness of evaluating hearing loss and recovery of idiopathic SSNHL on the [...] Read more.
Various prognostic factors for idiopathic sudden sensorineural hearing loss (SSNHL) have been reported. Hearing loss directly derived from idiopathic SSNHL is important for understanding underlying pathogenesis and outcomes. We assessed the usefulness of evaluating hearing loss and recovery of idiopathic SSNHL on the basis of estimated hearing loss. The study included 115 patients whose characteristics and outcomes of hearing loss were investigated. The effects of vertigo/dizziness and age on hearing thresholds before/after treatment, nonaffected ear threshold, estimated hearing loss, improvement of hearing loss, and estimated remaining hearing loss were investigated. Vertigo/dizziness was a significant prognostic factor for hearing. In vertigo/dizziness patients, significantly more severe hearing loss and poorer improvement of hearing loss were observed above 500 Hz and below 1000 Hz, respectively. Severe hearing disorder remained at all frequencies. Conversely, post-treatment thresholds were significantly higher in the older population (≥65 years), although no differences in pretreatment thresholds were observed between the younger (≤64 years) and older populations. However, on the basis of nonaffected ear thresholds, previously existing hearing loss could have influenced the outcome. Thus, comparison of hearing outcomes between affected and nonaffected ears is essential for understanding hearing loss and outcomes in idiopathic SSNHL cases with existing hearing disorder. Full article
(This article belongs to the Special Issue Recent Advances in the Treatment of Hearing Loss)
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