Auditory Disorders: Incidence, Intervention and Treatment

A special issue of Audiology Research (ISSN 2039-4349).

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 8466

Special Issue Editors

Department of Otolaryngology, Neurological Surgery Pediatrics and Biomedical Engineering, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA
Interests: cochlear implant; hearing preservation; otoprotection; inner ear therapy; stapectomy
Department of Otolaryngology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA
Interests: autism spectrum disorders; drug delivery; neuroprotection; neuroinflammation; behavioural neuroscience; gut microbiome; gut-brain axis

Special Issue Information

Dear Colleagues,

The objective of this special issue is to highlight the recent advancements regarding therapeutic interventions for auditory disorders including both conventional and alternate treatment modalities. This special issue will also include articles discussing advances for drug delivery in the inner ear as well as contribution of host genetics in predisposition to auditory disorders. We will also discuss the incidence of auditory disorders as a co-morbidity during various diseases such as autism. Original papers or review articles on topics including but not limited to:

  • New therapeutics for auditory disorders
  • Development of novel drug delivery approaches for inner ear
  • Nanoparticles as drug delivery vehicles in inner ear
  • Incidence and prevalence of auditory disorders as a co-morbidity
  • Pharmacokinetics in inner ear
  • Cochlear Implantation
  • Genetics and Auditory disorders.

Prof. Dr. Adrien Eshraghi
Dr. Rahul Mittal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Audiology Research is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inner ear and cochlea
  • drug delivery
  • pharmacokinetics
  • nanoparticles
  • prevalence of auditory disorders
  • auditory disorders
  • alternative therapies for auditoy disorders
  • cochlear implantation
  • genetics and auditory disorders
  • co-mobidities and auditory disorders

Published Papers (6 papers)

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Research

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9 pages, 987 KiB  
Article
Prevalence of Congenital Infections in Newborns and Universal Neonatal Hearing Screening in Santa Catarina, Brazil
by Eduarda Besen, Karina Mary Paiva, Luciana Berwanger Cigana, Marcos José Machado, Alessandra Giannella Samelli and Patrícia Haas
Audiol. Res. 2023, 13(1), 107-115; https://doi.org/10.3390/audiolres13010011 - 27 Jan 2023
Viewed by 1468
Abstract
Objective: to verify the frequency of congenital infections in newborns and their possible associations with the universal-neonatal-hearing-screening (UNHS) results, and evaluate a reference UNHS service in the Unified Health System (Sistema Único de Saúde—SUS), according to quality indicators. Methods: Historical cohort [...] Read more.
Objective: to verify the frequency of congenital infections in newborns and their possible associations with the universal-neonatal-hearing-screening (UNHS) results, and evaluate a reference UNHS service in the Unified Health System (Sistema Único de Saúde—SUS), according to quality indicators. Methods: Historical cohort study with data analysis of newborns attending prestigious hearing-health SUS services from January 2017 to December 2021, in Santa Catarina, Brazil. The quality of screening coverage was assessed based on the quality indicators proposed by the Brazilian neonatal-hearing-screening-care guidelines (Diretrizes de Atenção da Triagem Auditiva Neonatal—DATAN). Logistic-regression analysis, crude OR calculations, Cochran–Mantel–Haenszel OR calculation, and chi-square test were performed to estimate the association between risk indicators for hearing loss and UNHS failure. Results: In the last five years, the prestigious services performed UNHS on 34,801 newborns and met the DATAN quality indicators. Congenital syphilis was the most frequent (1.59%) congenital infection in newborns, followed by HIV (0.87%), whereas the least frequent was rubella (0.029%). Conclusion: Prestigious UNHS services reached ≥95% hearing screening coverage. Considering all congenital infections, the prevalence was 2.87%, with congenital syphilis the most frequent. Newborns with congenital syphilis or HIV are more likely to fail UNHS. Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
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Review

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27 pages, 1155 KiB  
Review
Incidence of Otolaryngological Manifestations in Individuals with Autism Spectrum Disorder: A Special Focus on Auditory Disorders
by Keelin McKenna, Soumil Prasad, Jaimee Cooper, Ava M. King, Shahriar Shahzeidi, Jeenu Mittal, Max Zalta, Rahul Mittal and Adrien A. Eshraghi
Audiol. Res. 2024, 14(1), 35-61; https://doi.org/10.3390/audiolres14010005 - 04 Jan 2024
Viewed by 1306
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by stereotyped and repetitive behavior patterns. In addition to neurological and behavioral problems, individuals with ASD commonly experience otolaryngological comorbidities. Individuals with ASD often have auditory disorders including hearing loss and auditory processing disorders [...] Read more.
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by stereotyped and repetitive behavior patterns. In addition to neurological and behavioral problems, individuals with ASD commonly experience otolaryngological comorbidities. Individuals with ASD often have auditory disorders including hearing loss and auditory processing disorders such as central auditory processing disorder (CAPD), as well as both chronic and recurrent otitis media. These challenges negatively impact a person’s ability to effectively communicate and may further impact their neurological functioning, particularly when not appropriately treated. Individuals diagnosed with ASD also have difficulty sleeping which contributes to increased irritability and may further aggravate the core behavioral symptoms of autism. The individuals with ASD also have a higher rate of sinusitis which contributes to the worsening of the autism behavior phenotype. The high prevalence of otolaryngological comorbidities in individuals with ASD warrants a better collaboration between their various healthcare providers and otolaryngologists with expertise in auditory, sleep, and sinus disorders in pursuit of improving the quality of life of affected individuals and their families/caregivers. Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
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12 pages, 964 KiB  
Review
Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders
by Dimitri A. Godur, Alexa J. Denton, Nicolas Eshraghi, Jeenu Mittal, Jaimee Cooper, Moeed Moosa and Rahul Mittal
Audiol. Res. 2023, 13(5), 741-752; https://doi.org/10.3390/audiolres13050066 - 10 Oct 2023
Viewed by 1875
Abstract
The gut microbiome has been shown to play a pivotal role in health and disease. Recently, there has been increased interest within the auditory community to explore the role of the gut microbiome in the auditory system and its implications for hearing disorders [...] Read more.
The gut microbiome has been shown to play a pivotal role in health and disease. Recently, there has been increased interest within the auditory community to explore the role of the gut microbiome in the auditory system and its implications for hearing disorders such as sensorineural hearing loss (SNHL), otitis media, and tinnitus. Studies have suggested that modulating the gut microbiome using probiotics as well as with diets high in monounsaturated and omega-3 fatty acids is associated with a reduction in inflammation prevalence in auditory disorders. This review aims to evaluate the current literature on modulation of the gut microbiome and its effects on otological conditions. The probiotic conversion of nondigestible carbohydrates into short-chain fatty acids has been shown to provide benefits for improving hearing by maintaining an adequate vascular supply. For acute and secretory otitis media, studies have shown that a combination therapy of probiotics with a decreased dose of antibiotics yields better clinical outcomes than aggressive antibiotic treatment alone. Gut microbiome modulation also alters neurotransmitter levels and reduces neuroinflammation, which may provide benefits for tinnitus by preventing increased neuronal activity. Further studies are warranted to evaluate the efficacy of probiotics, natural health products, and micronutrients on auditory disorders, paving the way to develop novel interventions. Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
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18 pages, 896 KiB  
Review
Management of Migraine-Associated Vestibulocochlear Disorders
by Kayla K. Umemoto, Karen Tawk, Najva Mazhari, Mehdi Abouzari and Hamid R. Djalilian
Audiol. Res. 2023, 13(4), 528-545; https://doi.org/10.3390/audiolres13040047 - 19 Jul 2023
Cited by 2 | Viewed by 2582
Abstract
Migraine is a chronic neurological disorder that frequently coexists with different vestibular and cochlear symptoms (sudden hearing loss, tinnitus, otalgia, aural fullness, hyperacusis, dizziness, imbalance, and vertigo) and disorders (recurrent benign positional vertigo, persistent postural perceptual dizziness, mal de debarquement, and Menière’s disease). [...] Read more.
Migraine is a chronic neurological disorder that frequently coexists with different vestibular and cochlear symptoms (sudden hearing loss, tinnitus, otalgia, aural fullness, hyperacusis, dizziness, imbalance, and vertigo) and disorders (recurrent benign positional vertigo, persistent postural perceptual dizziness, mal de debarquement, and Menière’s disease). Despite evidence of an epidemiological association and similar pathophysiology between migraine and these vestibulocochlear disorders, patients suffering from migraine-related symptoms are usually underdiagnosed and undertreated. Current migraine treatment options have shown success in treating vestibulocochlear symptoms. Lifestyle and dietary modifications (reducing stress, restful sleep, avoiding migraine dietary triggers, and avoiding starvation and dehydration) and supplements (vitamin B2 and magnesium) offer effective first-line treatments. Treatment with migraine prophylactic medications such as tricyclic antidepressants (e.g., nortriptyline), anticonvulsants (e.g., topiramate), and calcium channel blockers (e.g., verapamil) is implemented when lifestyle and dietary modifications are not sufficient in improving a patient’s symptoms. We have included an algorithm that outlines a suggested approach for addressing these symptoms, taking into account our clinical observations. Greater recognition and understanding of migraine and its related vestibular and cochlear symptoms are needed to ensure the appropriate diagnosis and treatment of affected patients. Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
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Other

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2 pages, 169 KiB  
Reply
Reply to Theodorou et al. Comment on “Umemoto et al. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol. Res. 2023, 13, 528–545”
by Najva Mazhari, Karen Tawk, Kayla K. Umemoto, Mehdi Abouzari and Hamid R. Djalilian
Audiol. Res. 2024, 14(1), 181-182; https://doi.org/10.3390/audiolres14010016 - 07 Feb 2024
Viewed by 265
Abstract
We thank the authors for their insightful and thoughtful commentary on our recent publication [...] Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
2 pages, 1266 KiB  
Comment
Comment on Umemoto et al. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol. Res. 2023, 13, 528–545
by Daphne J. Theodorou, Stavroula J. Theodorou and Vasilios Mitsios
Audiol. Res. 2024, 14(1), 179-180; https://doi.org/10.3390/audiolres14010015 - 07 Feb 2024
Cited by 1 | Viewed by 264
Abstract
We read with great interest the recent article by Umemoto, K. [...] Full article
(This article belongs to the Special Issue Auditory Disorders: Incidence, Intervention and Treatment)
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