One of the highest risk groups the highest during COVID-19 were chronic patients. In addition to being a population at risk, in the lockdown they had to combine the pandemic with their own disease. Through a qualitative study of visual–emotional analysis, the perception of patients and their social environment (immediate support network) about the domestic confinement in Spain was requested during the State of Alarm in the Spring of 2020. For this, 33 participants filled out an online questionnaire with narratives and images describing their experiences. They were asked to share their experiences about quarantine from several perspectives of the housing spaces: the workplace (or alternatively, if they did not work, the most used occupational space), the least pleasant spaces or aspects of the dwelling and the most pleasant or comfortable area. The results suggested the importance for participants of natural and adequate lighting in spaces and tidiness, with both being linked to well-valued spaces. Moreover, rest was the activity most undertaken, for those who did not telework. Likewise, the narratives provided by participants were mostly positive, despite their condition, maybe due to their own coping with the disease. Dwellings were the adaptive means to tackle the situation of physical isolation as a place of protection against an external threat. The living room and bedrooms were chosen as the most prominent places. The characteristics of the dwellings conditioned the experiences lived during the quarantine of chronic patients. Full article