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Applied Sciences
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Advanced Nanotechnologies in Drug Delivery
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Advanced Nanotechnologies in Drug Delivery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (10 July 2021) | Viewed by 5369

Special Issue Editors

Dr. Pio Maria Furneri

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Guest Editor
Department of Biomedical and Biotechnological Sciences BIOMETEC, University of Catania, Catania, Italy
Interests: antibacterial activity; antimycoplasma activity; antiviral activity; natural extract; essential oils; coronavirus; probiotics; drug delivery development
Special Issues, Collections and Topics in MDPI journals
Dr. Virginia Fuochi

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Guest Editor
Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy
Interests: drug delivery systems; solid lipid nanoparticles; intracellular distribution of antibiotics; enhancement of antibiotic spectrum of activity; probiotics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Rosario Pignatello

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Department of Drug and Health Sciences, University of Catania, V.le Andrea Doria, 6, 95125 Catania, Italy
Interests: drug delivery; nanomedicine; nanocarriers; biopolymers; pharmaceutical technology; ocular drug delivery; oral drug delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Angela Maria Amorini

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Department of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, Via Santa Sofia 87, 95125 Catania, Italy
Interests: neurodegenerative acute (traumatic brain injury) and chronic (multiple sclerosis) disorders; oxidative and nitrosative stresses; oxidation mechanisms
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Dr. Antonio Rescifina

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Department of Drug Sciences, University of Catania, 95125 Catania, Italy
Interests: organic synthesis; computational chemistry; computer aided drug design; molecular modeling; computational studies of reaction mechanisms; molecular docking; QSAR; 1,3-dipolar cycloadditions
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Margherita Ferrante

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Guest Editor
Environmental and Food Hygiene Laboratory (LIAA), University of Catania, 95125 Catania, Italy
Interests: environmental science; medicine; pharmacology, toxicology, and pharmaceutics

Special Issue Information

Dear Colleagues,

After two to three decades where various hypotheses and strategies were proposed and tested, most of which failed when facing industrial scale-up or real clinical usefulness, applications of technological approaches and platforms using nanoscaled systems (nanomedicine) are progressively assuming value in medicine as well as in clinical practice. We are now in a time where nanotechnology is mature enough to efficiently address its potentiality towards patients’ care, which is called “translational nanomedicine”. In this regard, proposals of new biomaterials and production methods from researchers are increasingly tailored to industrial feasibility and, above all, clinical needs.

For many years, cancer therapy has been gaining interest in drug delivery research, and today, other fields have become more and more attractive for nanotechnological tools, such as protein and peptide delivery, antimicrobial delivery, vaccine delivery, gene therapy, rare diseases, and, even more recently, the medical device industry.

This Special Issue is aimed at collecting relevant and high-level experimental studies on the new biomaterials and matrices that are able to produce nanosystems and nanodevices for the controlled release and targeting of drugs and other bioactive compounds, as well as to devise new systems to fight environmental contaminations of viruses, particularly human coronaviruses (SARS Cov, MERS, and new SARS COV 2) and animal coronaviruses. Moreover, particular attention will be devoted to “green nanomedicine”, as well as to bio-inspired, bioengineered, and biomimetic drug delivery carriers (such as virosomes, biohybrid drug delivery systems, bioengineered bacterial outer membrane vesicles, etc.); an interesting issue could also be the environmental application of antimicrobial coatings. Finally, research incorporating preclinical or clinical results will certainly be of great interest.

Prof. Dr. Pio Maria Furneri
Dr. Virginia Fuochi
Prof. Dr. Rosario Pignatello
Prof. Dr. Angela Maria Amorini
Dr. Antonio Rescifina
Prof. Dr. Margherita Ferrante
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

19 pages, 2102 KiB  
Article
Formulation Development, Statistical Optimization, In Vitro and In Vivo Evaluation of Etoricoxib-Loaded Eucalyptus Oil-Based Nanoemulgel for Topical Delivery
by Nabil A. Alhakamy, Sabna Kotta, Javed Ali, Md Shoaib Alam, Khaled M. Hosny, Rasheed A. Shaik, Basma G. Eid, Yassine Riadi, Hani Z. Asfour, Noha Ashy and Shadab Md
Appl. Sci. 2021, 11(16), 7294; https://doi.org/10.3390/app11167294 - 09 Aug 2021
Cited by 7 | Viewed by 3142
Abstract
Pain is a common distress in chronic inflammatory diseases, and etoricoxib (ETB) is frequently used in its management. It possesses fewer adverse effects when compared with other non-steroidal anti-inflammatory drugs (NSAIDs). In the present study, ETB-loaded nanoemulsion (ETB-NE) was formulated and optimized. Eucalyptus [...] Read more.
Pain is a common distress in chronic inflammatory diseases, and etoricoxib (ETB) is frequently used in its management. It possesses fewer adverse effects when compared with other non-steroidal anti-inflammatory drugs (NSAIDs). In the present study, ETB-loaded nanoemulsion (ETB-NE) was formulated and optimized. Eucalyptus oil, Tween 20, and PEG 200 were chosen as the oil, surfactant, and co-surfactant, respectively. The formulation was optimized using the Box–Behnken design. The optimized ETB-NE contained oil, Smix, and water in concentrations of 11.5, 38, and 50% respectively. It had droplet size, polydispersity index, and zeta potential values of 179.6 ± 4.21 nm, 0.373 ± 0.02, and −10.9 ± 1.01 mV, respectively. The optimized ETB-NE sample passed the thermodynamic stability and dispersibility tests. Transmission electron microscopy confirmed the spherical morphology of the NE droplets. The ETB-NE showed a biphasic drug release pattern and released 85.3 ± 1.8% of ETB at 12 h. The ETB-NE was formulated into nanoemulsion gel (NEG) by using 1% carbopol 934. ETB-NEG was characterized for pH, viscosity, drug content, and percentage entrapment efficiency. During in vitro permeation studies, the apparent permeability coefficient value was 0.072 cm−2 h−1 for ETB-NEG, while it was only 0.047 cm−2 h−1 for the ETB gel. The skin histopathology study results confirmed that the ETB-NEG formulation was non-irritant and safe for topical use. The maximum possible analgesia observed for ETB-NEG was significantly high (p < 0.05) with a value of 47.09% after 60 min. Similarly, a formalin-induced acute inflammatory pain study in rats also demonstrated higher analgesia for the ETB-NEG, with % inhibition values of 37.37 ± 5.9 and 51.95 ± 4.4 in the acute and late phases, respectively. Further, ETB-NEG showed 78.4 ± 3.5% inhibition at 8 h in the in vivo anti-inflammatory testing by rat paw edema method. The ETB-NEG was found to enhance the in vivo analgesic and anti-inflammatory effects of ETB. The study results could stimulate further studies in this area for establishing a clinically successful NEG formulation of ETB. Full article
(This article belongs to the Special Issue Advanced Nanotechnologies in Drug Delivery)
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14 pages, 2942 KiB  
Article
Assessment of the Technological Properties of Idebenone and Tocopheryl Acetate Co-Loaded Lipid Nanoparticles
by Maria Grazia Sarpietro, Cristina Torrisi, Rosario Pignatello, Francesco Castelli and Lucia Montenegro
Appl. Sci. 2021, 11(8), 3553; https://doi.org/10.3390/app11083553 - 15 Apr 2021
Cited by 1 | Viewed by 1399
Abstract
Several liquid lipids have been proposed to obtain nanostructured lipid carriers (NLC) with improved efficiency. An attractive strategy is the use of oils that could elicit a synergic effect with the loaded drug. In this work, different percentages (0–4% w/w) [...] Read more.
Several liquid lipids have been proposed to obtain nanostructured lipid carriers (NLC) with improved efficiency. An attractive strategy is the use of oils that could elicit a synergic effect with the loaded drug. In this work, different percentages (0–4% w/w) of tocopheryl acetate (TA), an oily antioxidant, were used as liquid lipid to prepare NLC loading idebenone (IDE), a synthetic antioxidant investigated for the treatment of neurodegenerative and topical diseases. The technological properties of such NLC were evaluated, as well as the interactions among lipid core components. Loading different percentages of IDE (1–4% w/w) into NLC containing TA up to 4% w/w, no significant change of mean size and polydispersity index was observed. IDE loading capacity was 4% w/w but NLC containing IDE percentages greater than 1.5% w/w showed poor stability during long-term storage. Differential scanning calorimetry analyses highlighted linear relationships between peak temperature and TA percentages, while the enthalpy variation and recrystallization index values showed that increasing the percentage of TA led to less crystalline structure of the NLC core. Therefore, NLC co-loading IDE and TA could be useful to design new delivery systems for the treatment of diseases that could benefit from the co-administration of these antioxidants. Full article
(This article belongs to the Special Issue Advanced Nanotechnologies in Drug Delivery)
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