Recent Advances in Bioreactor System: Design, Operation and Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 2506

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biology and Pharmaceutical Botany, Chair of Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
Interests: phytochemical analysis; secondary metabolites isolation; chromatographical methods; medicinal plant biotechnology; bioreactors for medicinal plant cultivation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioreactors are a vital tool in bioprocessing, providing a controlled environment for the growth of living cells of microorganisms, plants and fungi, thus enabling efficient and precise bioprocessing. The utilization of bioreactors leads to the establishment of effective control parameters for cell growth and valuable secondary metabolite biosynthesis. Utilizing culture in a bioreactor may also be a crucial step in the production of biomass and valuable natural compounds, from a laboratory to a semi-industrial and even industrial-scale process. Therefore, this Special Issue aims to present new data and experimental results both in the field of new bioreactor systems/prototypes, as well as known constructions used for novel, scientifically unexplored species of microorganisms, fungi and plants; this is particularly with regard to the production of high-efficiency biomass and the biosynthesis of valuable natural compounds . This Special Issue will publish high-quality, original scientific papers that provide new data on bioreactor cultures with a focus on novel, more efficient scalable bioprocessing systems.

Prof. Dr. Łukasz Kuźma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • bioreactor cultures
  • quantitative determination of the natural products
  • biotechnological investigations

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 7925 KiB  
Communication
GreenTray®, a TIS Bioreactor for Plant Micropropagation and Abiotic or Biotic Stress Bioassays
by Ramon Dolcet-Sanjuan, Maria Casanovas, Sandra Franquesa, Eva Alsina, Francisca Carrasco-Cuello, Estanis Torres, Josep Rufat, Cristina Solsona and Neus Teixido
Appl. Sci. 2024, 14(10), 4051; https://doi.org/10.3390/app14104051 - 10 May 2024
Viewed by 364
Abstract
The temporary immersion system bioreactor named GreenTray® presents advantages over the existing ones. Firstly, there is no need to use forceps to move the shoots or plantlets in or out of the recipient, nor is the use of a scalpel necessary to [...] Read more.
The temporary immersion system bioreactor named GreenTray® presents advantages over the existing ones. Firstly, there is no need to use forceps to move the shoots or plantlets in or out of the recipient, nor is the use of a scalpel necessary to divide them. Secondly, the basis of the shoot can remain in the GreenTray® and can sprout again over several cycles of growth. These two characteristics reduce the costs in the process of micropropagation. In addition, shoot or plantlet development is enhanced by the aeration of the recipient, thus enriching the recipient’s atmospheric CO2. This article describes and provides images and values of interest in (1) the micropropagation process of some commercial Prunus or Pyrus rootstocks; (2) the plantlet growth under autotrophic conditions; and (3) the inoculation of plants with pathogens that reproduce in vitro the symptoms observed in vivo, using the GreenTray® bioreactor. Full article
Show Figures

Figure 1

14 pages, 1118 KiB  
Article
Use of Bayesian Methods in the Process of Uranium Bioleaching by Acidithiobacillus ferrooxidans
by Altair Costa Cardoso, Camila Santana Dias, Carlos Henrique Rodrigues de Moura, Josiel Lobato Ferreira, Emerson Cardoso Rodrigues, Emanuel Negrão Macêdo, Diego Cardoso Estumano and Bruno Marques Viegas
Appl. Sci. 2024, 14(1), 109; https://doi.org/10.3390/app14010109 - 22 Dec 2023
Viewed by 828
Abstract
This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching [...] Read more.
This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching process by Acidithiobacillus ferrooxidans. Experimental data of cell concentration, uranium concentration, and concentrations of ferrous and ferric ions, obtained from literature, were employed. These measurements were evaluated using a mathematical model expressed by a system of ordinary differential equations. Three different mathematical models were evaluated, considering different uncertainties in experimental measurements and mathematical models (1% and 5%). The estimation results presented a good fit to the experimental data, with coefficients of determination in the range of 0.95 to 0.99. The validation of the mathematical models was obtained by reproducing the experimental measurements and the Bayesian techniques proved to be suitable for application in the bioleaching process. Full article
Show Figures

Figure 1

Review

Jump to: Research

22 pages, 633 KiB  
Review
Exploring Key Parameters in Adsorption for Effective Fluoride Removal: A Comprehensive Review and Engineering Implications
by Letícia Reggiane de Carvalho Costa, Ivone Vanessa Jurado-Davila, Júlia Toffoli De Oliveira, Keila Guerra Pacheco Nunes, Diego Cardoso Estumano, Robson Alves de Oliveira, Elvis Carissimi and Liliana Amaral Féris
Appl. Sci. 2024, 14(5), 2161; https://doi.org/10.3390/app14052161 - 5 Mar 2024
Viewed by 932
Abstract
Water pollution, particularly from elevated fluoride ion (F) concentrations, is a significant challenge in many developing countries, particularly those relying on groundwater. The stable form of fluoride, F, poses health risks, leading to concerns about various diseases and harmful [...] Read more.
Water pollution, particularly from elevated fluoride ion (F) concentrations, is a significant challenge in many developing countries, particularly those relying on groundwater. The stable form of fluoride, F, poses health risks, leading to concerns about various diseases and harmful effects. Despite global efforts, high F concentrations (>1.5 mg L−1) persist in numerous countries, requiring effective and sustainable removal methods. Adsorption, known for its simplicity, cost-effectiveness, and efficiency, stands out as a promising technique for F removal from drinking water. Successful commercial implementation necessitates the optimization of separation conditions. This systematic literature review focuses on the adsorption process for F removal, exploring parameters such as temperature, adsorbent particle size, pH, adsorbent mass, and co-existing ions for efficient removal. Observations indicate that, despite the utilization of a diverse range of adsorbents, several limitations persist. These include low adsorption capacity, a sluggish adsorption rate, a restricted pH range, and high associated costs. The mechanistic understanding of adsorption and the ongoing development of novel adsorbents remain focal points for future research. Additionally, there is a need to explore alternative kinetic models grounded in statistical factors and give due consideration to thermodynamic studies. Full article
Show Figures

Figure 1

Back to TopTop