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Applied Sciences
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Recent Developments in the Use of Nanoparticles for Treatment of...
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Recent Developments in the Use of Nanoparticles for Treatment of Biofilms

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5482

Special Issue Editors

Dr. Farrukh Aqil

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Guest Editor
Department of Medicine, University of Louisville, Louisville, KY 40202, USA
Interests: drug delivery; nanotechnology; cancer chemoprevention and treatment; breast; lung and ovarian cancers; exosomes
Special Issues, Collections and Topics in MDPI journals
Dr. Fohad Mabood Husain

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Guest Editor
Department of Food Science and Nutrition, King Saud University, Riyadh 11362, Saudi Arabia
Interests: PCR; antimicrobials; microbial molecular biology; molecular microbiology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Iqbal Ahmad

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Guest Editor
Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002, India
Interests: general microbiology; pathogenic microbes and drug resistance; soil microbiology; industrial microbiology and fermentation technology; biomolecules; bacterial genetics; plasmid biology
Special Issues, Collections and Topics in MDPI journals
Dr. Mohammad Oves

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Guest Editor
Center of Excellence in Environmental Studies, King Abdul Aziz University, Jeddah, Saudi Arabia
Interests: nanoparticles; antimicrobial activity; green synthesis; drug screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biofilms are complex structures, mainly composed of microbial cells embedded in extrapolymeric substances which are secreted by microbes themselves. The earlier assumption of bacterial growth was that bacteria grow in planktonic mode. However, recent advancements have confirmed that most of the bacteria in environment grow as biofilms. Biofilms are considered a serious threat in the management of infections in clinical settings. Moreover, biofilms developing on medical implant devices and implants exert an extra burden on human health. The importance of biofilms can be estimated from National Institutes of Health (NIH) estimates, which states that nearly 80 percent of all known human infections are related to biofilms. The Centers for Disease Control and Prevention (CDC) has found that more than 65 percent of hospital-acquired infections are associated with biofilms. The biofilms developed in persistent infections are difficult to overcome through the immune response of the host. Therefore, there is an urgent need for the development of novel antibiofilm agents. In the last few decades, nanotechnology has emerged as a promising discipline of science owing to its novel applications. Nanomaterials such as silver, platinum, gold, titanium, iron, zinc, etc., are a great choice for biomedical applications, especially for the management of biofilms. It is thought that nanomaterials may prove to be of interest for wound dressings and coating of medical devices to prevent the formation of biofilms.

This Special issue aims to collect research papers focused on nanomaterials capable of inhibiting biofilms, with special reference to the mechanism of antibiofilm action. We expect that this Special issue will contribute to the recent advancement in the use of nanoparticles for the treatment of biofilms.

Dr. Farrukh Aqil
Dr. Fohad Mabood Husain
Dr. Iqbal Ahmad
Dr. Mohammad Oves
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanocomposites
  • bacteria
  • fungi
  • biofilm
  • quorum sensing

Published Papers (2 papers)

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Research

13 pages, 3593 KiB  
Article
Ajwa-Dates (Phoenix dactylifera)-Mediated Synthesis of Silver Nanoparticles and Their Anti-Bacterial, Anti-Biofilm, and Cytotoxic Potential
by Khaled S. Allemailem, Habeeb Khadri, Mohd Azam, Masood Alam Khan, Arshad Husain Rahmani, Faris Alrumaihi, Riazunnisa Khateef, Mohammad Azam Ansari, Eid A. Alatawi, Mahdi H. Alsugoor, Nahlah Makki Almansour, Bader Y. Alhatlani and Ahmad Almatroudi
Appl. Sci. 2022, 12(9), 4537; https://doi.org/10.3390/app12094537 - 29 Apr 2022
Cited by 14 | Viewed by 2319
Abstract
Green nanotechnology is the evolution of cost-effective and environmentally friendly processes for the production of metal-based nanoparticles due to medicinal importance and economic value. The aim of the present study was to biosynthesize and characterize silver nanoparticles (AgNPs) using the seed extract of [...] Read more.
Green nanotechnology is the evolution of cost-effective and environmentally friendly processes for the production of metal-based nanoparticles due to medicinal importance and economic value. The aim of the present study was to biosynthesize and characterize silver nanoparticles (AgNPs) using the seed extract of Ajwa dates (Aw). The anti-bacteriostatic activity of biosynthesized Aw–AgNPs against Gram-positive and Gram-negative bacterial strains was evaluated. The anti-biofilm activity was examined by the tissue culture plate method. Lastly, the anti-cancer potential of Aw–AgNPs was investigated against the human breast cancer cell line HCC712. UV–visible absorption spectra exhibited the plasmon resonance peak at 430 nm, with the solution undergoing rapid color changes that verified the existence of biosynthesized silver nanoparticles in the solution. TEM and SEM images illustrated that the Aw–AgNPs were spherical and between 15 and 80 nm in diameter. The reduction and stabilization of Aw–AgNPs was due to the functional groups present in the biomolecules of the Ajwa seeds, as identified by FTIR. The Aw–AgNPs exhibited significant anti-bacterial activity against all the tested bacterial strains. Moreover, the Aw–AgNPs efficiently hampered the biofilm formation of the bacterial strains and exhibited cytotoxicity at various concentrations. Overall, these findings suggest that biosynthesized Aw–AgNPs may be used as a potential therapeutic formulation against bacterial infections and breast cancer. Full article
(This article belongs to the Special Issue Recent Developments in the Use of Nanoparticles for Treatment of Biofilms)
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15 pages, 5628 KiB  
Article
Biosynthesized Zinc Oxide Nanoparticles Disrupt Established Biofilms of Pathogenic Bacteria
by Fohad Mabood Husain, Faizan Abul Qais, Iqbal Ahmad, Mohammed Jamal Hakeem, Mohammad Hassan Baig, Javed Masood Khan and Nasser A. Al-Shabib
Appl. Sci. 2022, 12(2), 710; https://doi.org/10.3390/app12020710 - 12 Jan 2022
Cited by 24 | Viewed by 2402
Abstract
Global emergence and persistence of the multidrug-resistant microbes have created a new problem for management of diseases associated with infections. The development of antimicrobial resistance is mainly due to the sub-judicious and unprescribed used of antimicrobials both in healthcare and the environment. Biofilms [...] Read more.
Global emergence and persistence of the multidrug-resistant microbes have created a new problem for management of diseases associated with infections. The development of antimicrobial resistance is mainly due to the sub-judicious and unprescribed used of antimicrobials both in healthcare and the environment. Biofilms are important due to their role in microbial infections and hence are considered a novel target in discovery of new antibacterial or antibiofilm agents. In this article, zinc oxide nanoparticles (ZnO-NPs) were prepared using extract of Plumbago zeylanica. ZnO-NPs were characterized and then their antibiofilm activity was tested against Gram-positive and Gram-negative bacteria. The ZnO-NPs were polydispersed, and the average size was obtained as 24.62 nm. The presence of many functional groups indicated that phytocompounds of P. zeylanica were responsible for the synthesis, capping, and stabilization of ZnO-NPs. Synthesized NPs inhibited the biofilm formation of E. coli, S. aureus, and P. aeruginosa by 62.80%, 71.57%, and 77.69%, respectively. Likewise, concentration-dependent inhibition of the EPS production was recorded in all test bacteria. Microscopic examination of the biofilms revealed that ZnO-NPs reduced the bacterial colonization on solid support and altered the architecture of the biofilms. ZnO-NPs also remarkably eradicated the preformed biofilms of the test bacteria up to 52.69%, 59.79%, and 67.22% recorded for E. coli, S. aureus, P. aeruginosa, respectively. The findings reveal the ability of green synthesized zinc oxide nanoparticles to inhibit, as well as eradicate, the biofilms of Gram-positive and Gram-negative bacteria. Full article
(This article belongs to the Special Issue Recent Developments in the Use of Nanoparticles for Treatment of Biofilms)
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