Natural and Synthetic Antimicrobial Substances: Novel Advances and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 1007

Special Issue Editors


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Guest Editor
Department of Chemical Sciences, University of Naples “Federico II”, Via Cinthia 4, 80126 Napoli, Italy
Interests: biochemistry; mass spectrometry; proteomic; nanoparticles; protein expression; live cell imaging; western blot analysis; protein purification; cloning; DNA extraction; bacterial cell culture; plasmid cloning
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Guest Editor
Department of Chemical Sciences, Università Federico II di Napoli, Vicinale Cupa Cintia 26, 20126 Naples, Italy
Interests: biologia molecolare; sistemi riparo DNA; molecular microbiology; biomolecule; antimicrobial peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of new drugs able to counteract pathogenic microbes is crucial in many fields of application due to the large increase in drug-resistant bacterial strains.

The growing problem of resistance to conventional antibiotics and the need for new antibiotics has stimulated interest in the development of new possible human therapy. Much interest has been directed towards natural molecules or antimicrobial peptides. In this respect, the study of their mechanisms of action and the identification of their protein targets could increase their specificity and power of action, leaving pathogens exposed to antibiotic treatments.

This Special Issue will be dedicated not only to the study on new antimicrobial compounds, natural or synthetic, but also to studies on already-existing compounds to identify specific protein targets and develop new molecules with improved antimicrobial profiles.

Dr. Angela Di Somma
Prof. Dr. Angela Duilio
Guest Editors

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Keywords

  • antimicrobial agents
  • natural compounds
  • antimicrobial peptides
  • protein targets
  • biochemistry approaches
  • proteomic techniques
  • pathogenic and non-pathogenic bacteria

Published Papers (2 papers)

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Research

13 pages, 1880 KiB  
Article
Selected Useful Properties of Polylactide Films Containing Nisaplin and Natamax
by Agnieszka Richert, Katarzyna Dembińska, Natalia Hejda, Paulina Brzęcka, Magdalena Lewandowska and Maria Swiontek Brzezinska
Appl. Sci. 2024, 14(9), 3754; https://doi.org/10.3390/app14093754 - 28 Apr 2024
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Abstract
In this article, we present polymer materials consisting of polylactide (PLA) and nisaplin (N), as well as PLA and natamax (X). These materials were obtained using the solvent method and tested by various test methods, i.e., functional properties—water vapor permeability, light transmission, gloss, [...] Read more.
In this article, we present polymer materials consisting of polylactide (PLA) and nisaplin (N), as well as PLA and natamax (X). These materials were obtained using the solvent method and tested by various test methods, i.e., functional properties—water vapor permeability, light transmission, gloss, and bactericidal activity against strains E. coli (ATCC 8739P), S. aureus (ATCC 65388), and P. aeruginosa (ATCC 8739). Furthermore, analyses were conducted to evaluate their efficacy against pathogenic fungi, including A. niger, A. flavus, A. glaucus, and A. versicolor. Mutagenicity analyses were performed using the standard Ames Test with Salmonella typhimurium. The main test methods used were ISO 22196, ISO 846. The results obtained confirm the potential suitability of the films of PLA with nisaplin and natamax for applications in the food packaging industry. Full article
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20 pages, 1630 KiB  
Article
Novel Adamantane Derivatives: Synthesis, Cytotoxicity and Antimicrobial Properties
by Łukasz Popiołek, Wiktoria Janas, Anna Hordyjewska and Anna Biernasiuk
Appl. Sci. 2024, 14(9), 3700; https://doi.org/10.3390/app14093700 - 26 Apr 2024
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Abstract
Seventeen adamantane derivatives were synthesized according to facile condensation reaction protocols. Spectral analysis (1H NMR and 13C NMR) was applied to confirm the chemical structure of the obtained substances. The synthesized compounds were tested for in vitro antimicrobial activity against [...] Read more.
Seventeen adamantane derivatives were synthesized according to facile condensation reaction protocols. Spectral analysis (1H NMR and 13C NMR) was applied to confirm the chemical structure of the obtained substances. The synthesized compounds were tested for in vitro antimicrobial activity against a panel of Gram-positive and Gram-negative bacterial strains and towards fungi from Candida spp. Among them, four derivatives numbered 9, 14, 15 and 19 showed the highest antibacterial potential with MIC = 62.5–1000 µg/mL with respect to all Gram-positive bacteria. S. epidermidis ATCC 12228 was the most susceptible among the tested bacterial strains and C. albicans ATCC 10231 among fungi. Additionally, the cytotoxicity for three derivatives was measured with the use of the MTT test on A549, T47D, L929 and HeLa cell lines. Our cytotoxicity studies confirmed that the tested substances did not cause statistically significant changes in cell proliferation within the range of the tested doses. Full article
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