Fiber Optics: Internet to Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2664

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Guest Editor
Department of Electrical & Computer Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Interests: contactless physiological measurement systems; occupant monitoring and driver monitoring systems in vehicles; brain imaging for traumatic brain injury and monitoring patients; active illumination for remote sensing systems; super-continuum and other fiber laser technologies
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Special Issue Information

Dear Colleagues,

As the world's population grows and lives longer, healthcare providers around the world are increasingly seeking advanced biomedical tools that enable more-efficient patient diagnosis, monitoring, and treatment. In this regard, the application of fiber optics to biomedical sensors is becoming increasingly important. At the same time, recent advances in minimally invasive surgery (MIS) require smaller disposable sensor catheters. The integration of fiber optics into the medical community has enabled safer procedures, more-efficient surgeries, faster recovery times, and better diagnostic investigations. The ideal properties of optical fibers, such as adaptability to sterility and a small dimensional size, offer many opportunities for the development of medical devices.

The topics of interest include, but are not limited to, the following: fiber optic technology: material and fabrication, microstructured fibers, and highly nonlinear fibers; pulse propagation in nonlinear optical fibers: optical solitons, pulse shaping, pulse compression, pulse broadening, nonlinear optical processes, and all-optical tunable delays; and biomedical applications: diagnostic and therapeutic devices based on fiber optics, optical fiber catheters, laparoscopic devices using fibers, selective tissue ablation, and tissue imaging with different penetration depths.

Prof. Dr. Mohammed N. Islam
Guest Editor

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Keywords

  • nonlinear fiber optic technology
  • optical fibers
  • optical sensors
  • pharmaceuticals
  • optical fiber catheters
  • laparoscopic devices using fibers

Published Papers (1 paper)

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Research

39 pages, 13865 KiB  
Article
Noninvasive Monitoring of Metabolism and Hemodynamics Using Super-Continuum Infrared Spectroscopy of a Cytochrome C Oxidase (SCISCCO) Instrument
by Mohammed N. Islam, Tianqu Zhai, Alexander Dobre, Cynthia N. Meah, Ioulia Kovelman, Steven Broglio, Daniel A. Beard, Xiaosu Hu, Jacob R. Joseph, Yamaan S. Saadeh, Rachel Russo and Hasan B. Alam
Appl. Sci. 2022, 12(19), 10122; https://doi.org/10.3390/app121910122 - 09 Oct 2022
Cited by 1 | Viewed by 2242
Abstract
We present a novel, noninvasive, super-continuum infrared spectroscopy of cytochrome c oxidase (SCISCCO) system for simultaneously measuring hemodynamic and metabolic parameters, and we demonstrate its utility by applying it to lab calibration tests, human studies, and swine animal studies. The system optically assays [...] Read more.
We present a novel, noninvasive, super-continuum infrared spectroscopy of cytochrome c oxidase (SCISCCO) system for simultaneously measuring hemodynamic and metabolic parameters, and we demonstrate its utility by applying it to lab calibration tests, human studies, and swine animal studies. The system optically assays the redox state of cytochrome c oxidase (CCO), as well as traditional markers including oxygenated (HbO) and deoxygenated (HbR) hemoglobin. To demonstrate in vivo feasibility, the measured responses of oxygenation and CCO responses to acute ischemia on the arm and forehead in human participants are compared to data from the literature. The validated SCISCCO system is then applied in human studies to measure cerebral oxygenation and the redox state of CCO in participants during an attention test protocol. We show that the redox state of CCO and hemodynamics measured by the SCISCCO system are consistent with the physiological hypothesis established in prior studies. To enable use of the SCISCCO system in laboratory and hospital settings as well as transportation to remote locations, a cart-based SCISCCO prototype system has also been developed. The cart-based SCISCCO prototype is applied to swine animal models undergoing induction of hemorrhagic shock followed by partial resuscitative endovascular balloon occlusion of the aorta (pREBOA). The pilot study demonstrates the feasibility of using the SCISCCO instrument within the context of existing protocols and validates the instrument’s measurements against the physiological and hemodynamic parameters measured by other conventional devices. Full article
(This article belongs to the Special Issue Fiber Optics: Internet to Biomedical Applications)
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