Artificial Intelligence Applications in Healthcare and Precision Medicine

Dear Colleagues,

As a result of its rapid expansion, artificial intelligence (AI) is becoming a powerful tool serving numerous fields, including medicine. Its applications range from diagnostics to surgery, from drug development to rehabilitation, and from remote monitoring to patient assistance, and continue to grow exponentially.

Indeed, artificial intelligence in the medical field is now conceived as an aid to modern medicine. It is precisely in this scenario that technological tools and software used in the medical field are undergoing radical changes, with strong innovations to enable increasingly early advanced diagnoses and more and more personalized therapies, and in general to improve patients’ experience.

In the era of big-data and omics sciences, global health care is trying to move beyond the historical "one-size-fits-all" medical approach—in which one strategy fits all cases—to embrace an increasingly personalized approach uniquely designed specifically for the patient, taking advantage of each person's individual differences such as their genotype, environment and lifestyle.

In particular, in recent years, there have been tremendous advances in the applications of AI in a variety of omics studies, including genomics, transcriptomics, proteomics, metabolomics, radiomics, etc., and all multi-omics integration approaches. It is therefore highly timely to discuss the potential impact of the insights generated by new machine learning (ML) and deep learning (DL) technologies on medical support, clinical decisions, clinical research, pharmaceutical industry and the entire patient pathway, which seeks to be as personalized as possible.

From another perspective, large language models (LLMs), based on DL and trained on huge amounts of text data, allow the generation of new text close to human responses, with the goal of producing virtual assistants and chatbots to provide personalized patient support, answering medical queries, scheduling appointments, and offering basic triage services.

The goal of this Special Issue is therefore to provide a series of articles highlighting the new opportunities, challenges and perspectives of AI tools in the light of precision medicine.

Both theoretical and experimental and case studies are welcome.

Dr. Giorgio De Nunzio
Dr. Luana Conte
Guest Editors

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• artificial intelligence
• machine learning
• deep learning
• omics sciences
• precision medicine
• personalized medicine
• genomics
• proteomics
• metabolomics
• radiomics
• radiogenomics
• robotic surgery
• assisting technologies
• health monitoring
• computer-assisted detection/diagnosis
• chatbots
• medical imaging
• disease prediction
• prognostics
• drug discovery

Title: Mammogram Classification with HanmanNets using Hanman Transform Classifier
Authors: Hanmandlu Madasu
Affiliation: Indian Institute of Technology Delhi
Abstract: Breast cancer is a deadly disease and radiologists recommend mammography to detect it at the early stages. This paper presents two types of HanmanNets using the information set concept for extracting the features from the Deep learning architectures and also the Hanman transform classifier for the classification of mammograms. The HanmanNets allow the modification of Kernel functions and feature maps of ResNet architectures (Type-1), and the final feature maps from AlexNet, GoogLeNet, and VGG-16 (Type-2).In this work, the type and the characteristics of the abnormality present are captured through the features from mammograms using CNN architectures and HanmanNets for a comparison of their classification performance. The highest accuracy of 100% is achieved for the multi-class classifications on the mini-MIAS database thus surpassing the results in the literature. Validation of the results is done by expert radiologists to make them clinically relevant.