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Applied Sciences
Special Issues
Recent Trends in Drug Screening, Development and Delivery
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Recent Trends in Drug Screening, Development and Delivery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2259

Special Issue Editors

Dr. Mohsin Khurshid

E-Mail Website
Guest Editor
Institute of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan
Interests: gut microbiota; antimicrobial resistance; One Health; environmental microbiology; antimicrobial resistance genes
Special Issues, Collections and Topics in MDPI journals
Dr. Abdul Ahad

E-Mail Website1 Website2
Guest Editor
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: drug delivery; lipid based formulations; vesicles formulations; solubility enhancement

Special Issue Information

Dear Colleagues,

The screening and development of drugs are the principal steps to commercialize advanced pharmaceutical and biotechnology products to fulfill the need of clinical settings. The continued developments in the field of “drug discovery” provide an endless source of candidate drugs that could be approved for clinical use after preclinical and clinical trials. The novel approaches being used for drug discovery and development are of paramount interest to all the stakeholders of the healthcare industry including patients, clinicians, and pharmaceutical and biotechnology companies. The development of new tools and the improvements of existing tools are helping chemists in the drug discovery process extending from the candidate molecules to clinically useful drugs. Such innovations encompass improved drug screening protocols, in silico approaches, computational tools for toxicity analysis, advances in molecular biology and combinatorial chemistry that have simplified the screening and identification of numerous molecular targets simultaneously, and the development of novel screening methods. These new approaches are expected to increase the probability of success for any particular drug candidate, decrease the time and cost of development of drugs from a concept to market that will facilitate human efforts towards the development of cost-effective, clinically efficient, and safer pharmaceutical and biotechnology products offering enhanced clinical outcomes. The drug delivery process uses various formulation development approaches to make consuming drugs easier, less frequent and more effective for patients. 

This Special Issue, “Recent Trends in Drug Screening, Development and Delivery”, is focused on but not limited to newer approaches in the form of original research articles and reviews related to the various aspects of methodologies for the discovery of various agents and will present the recent trends in research related to the discovery, development, and all delivery aspects of drugs, pharmaceuticals and biotechnology products. 

Dr. Mohsin Khurshid
Dr. Abdul Ahad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug development
  • drug delivery
  • computational methods
  • target binding
  • structural data
  • natural products
  • toxicology
  • toxicity prediction
  • formulation development

Published Papers (2 papers)

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Research

22 pages, 8263 KiB  
Article
Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids
by Egor I. Nagaev, Elena A. Molkova, Vladimir I. Pustovoy, Tatyana A. Matveeva, Dmitry A. Zakharov, Alexander V. Simakin, Evgenia V. Stepanova, Natalia A. Semenova, Veronika E. Reut, Valery P. Kalinitchenko, Valery A. Kozlov and Nikolai F. Bunkin
Appl. Sci. 2023, 13(24), 13055; https://doi.org/10.3390/app132413055 - 07 Dec 2023
Viewed by 738
Abstract
The influence of various mechanical influences (transfusion, stirring, vibration, shaking, etc.) and magnetic installations (used in the application of spin chemistry methods) on colloidal solutions of protein and water, which are often used in pharmaceutical production, was studied. It has been shown that [...] Read more.
The influence of various mechanical influences (transfusion, stirring, vibration, shaking, etc.) and magnetic installations (used in the application of spin chemistry methods) on colloidal solutions of protein and water, which are often used in pharmaceutical production, was studied. It has been shown that when mechanical influences are applied, physical and chemical properties of water and aqueous colloids of the IgG protein are changed. Magnetic fields do not have a significant effect on water; however, variation in a number of physical and chemical characteristics is observed in protein colloids. Moreover, the effect after exposure to magnetic fields with a frequency of 8 Hz is higher compared to the effect after exposure to magnetic fields with a frequency of 50 Hz. This effect persists even at extremely low concentrations of IgG protein molecules. The measurement system proposed in this work makes it possible to monitor the state of protein molecules in a non-invasive mode. In the future, optical and potentiometric methods built into flow systems can be used at all stages of the production of protein pharmaceuticals. Full article
(This article belongs to the Special Issue Recent Trends in Drug Screening, Development and Delivery)
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22 pages, 7703 KiB  
Article
Solid Dispersions of Gefitinib with D-α-Tocopherol Polyethylene Glycol-1000 Succinate and 2-Hydroxypropyl β-Cyclodextrin Complex Improved Their Solubility, Dissolution and Apoptosis against A549 Cells
by Mohd Abul Kalam, Adel Ali Alhowyan, Sulaiman S. Alhudaithi, Mohd Shahnawaz Khan, Abdullah K. Alshememry and Musaed Alkholief
Appl. Sci. 2023, 13(19), 10859; https://doi.org/10.3390/app131910859 - 29 Sep 2023
Viewed by 796
Abstract
This study focuses on the development and characterization of solid dispersions (SDs) of Gefitinib (GEF) to improve its aqueous solubility and therapeutic activity against lung cancer. SDs were prepared by the co-precipitation method with tocopheryl-polyethylene-glycol succinate-1000 (TPGS) (F1), sodium lauryl sulfate (SLS) (F2) [...] Read more.
This study focuses on the development and characterization of solid dispersions (SDs) of Gefitinib (GEF) to improve its aqueous solubility and therapeutic activity against lung cancer. SDs were prepared by the co-precipitation method with tocopheryl-polyethylene-glycol succinate-1000 (TPGS) (F1), sodium lauryl sulfate (SLS) (F2) and complexation of F1 with hydroxypropyl β-cyclodextrin (HP-β-CD) (F3). Optimal formulations (F1 and F3) were used against A549 cells to determine the apoptosis, expressions of p53 and caspases. F3 has shown the highest solubility (1271.21 µg/mL), followed by F1 (1003.69 µg/mL), F2 (707.81 µg/mL) and GEF pure (303.85 µg/mL) in 0.1N HCl. Dissolution at 1.2 pH significantly enhanced the release from F3 (99.19%), followed by F1 (94.76%), F2 (85.70%) and GEF pure (37.26%) during 120 min. Complexation of GEF–TPGS with HP-β-CD significantly improved drug release with high dissolution efficiency (78.57%) in 24.9 min of mean dissolution time. Differential scanning calorimetry revealed crystalline to amorphous conversion of GEF in SDs, which was confirmed by scanning electron microscopy. Fourier transform infrared and proton nuclear magnetic resonance spectral analysis revealed no interaction between GEF and excipients. The IC50 values were 2.239, 3.135 and 4.471 µM for F3, F1 and GEF pure, respectively, against A549 cells. Increased expressions of p53 (5.9-, 4.6- and 3.04-fold), caspase-3 (5.38-, 3.78- and 3.01-fold) and caspase-9 (5.35-, 3.76- and 2.47-fold) in the case of F3, F1 and GEF pure, respectively, as compared to the untreated A549 cells indicated improved apoptotic potential of the SDs. TPGS SDs and their complexation with HP-β-CD improved the solubility, dissolution and efficacy of GEF against A549 cells. So, they can be a suitable alternative to the conventional GEF formulations against non-small-cell lung cancers. Full article
(This article belongs to the Special Issue Recent Trends in Drug Screening, Development and Delivery)
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