Advanced Applications of Metal-Organic Frameworks (MOFs)

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 March 2024 | Viewed by 500

Special Issue Editor

School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Richmond Road, Bradford, West Yorkshire BD7 1DP, UK
Interests: metal-organic frameworks (MOFs); hybrid nanomaterials and composites; polynuclear complexes; gas storage and separation; drug delivery; delivery of agrochemicals; molecular magnetism; catalysis

Special Issue Information

Dear Colleagues,

Metal–organic frameworks (MOFs) have attracted much attention for use in a variety of applications owing to their high adsorption capacities compared to other porous materials. Using different organic and inorganic constituents, MOFs can be synthesized in a variety of sizes and morphologies, and with different porosities and surface functionalities. Accordingly, MOFs and their derivatives have been employed in many applications. In this Special Issue, we welcome the submission of original research, reviews, and perspective articles that discuss the latest applications of MOFs.

Dr. Sanjit Nayak
Guest Editor

Manuscript Submission Information

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Keywords

  • metal–organic framework
  • catalysis
  • gas storage
  • separation
  • energy storage
  • sensing

Published Papers (1 paper)

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Research

20 pages, 4968 KiB  
Article
Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells
Appl. Sci. 2024, 14(5), 1902; https://doi.org/10.3390/app14051902 - 26 Feb 2024
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Abstract
Mitoxantrone (MTX) is a drug employed in breast cancer treatment, but its application is largely limited due to side effects. A controlled delivery approach can potentially reduce the side effects. In this study, two zirconium (Zr)-based MOFs, UiO-66 and UiO-66-NH2, were [...] Read more.
Mitoxantrone (MTX) is a drug employed in breast cancer treatment, but its application is largely limited due to side effects. A controlled delivery approach can potentially reduce the side effects. In this study, two zirconium (Zr)-based MOFs, UiO-66 and UiO-66-NH2, were studied for a more controlled delivery of MTX with a 40% and 21% loading capacity, respectively. Characterisation via powder X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectrometry, scanning electron microscopy, and dynamic light scattering confirmed the integrity of structure post-MTX loading. UV–vis spectrophotometry revealed distinctive release profiles, with UiO-66-MTX exhibiting a 25% cumulative release after 96 h in water and 120 h in PBS +10% FBS. UiO-66-NH2-MTX displayed a more sustained release, reaching 62% in water and 47% in PBS +10% FBS after 168 h. The interaction between MTX and the MOFs was also proposed based on computational modelling, suggesting a stronger interaction of UiO-66NH2 and MTX, and an optimised interaction of MTX in the tetrahedral and octahedral pores of the MOFs. The study also reports the release profile of the drug and antiproliferative activity against a panel of breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF7) and a normal breast epithelial cell line (MCF10A). MTX-encapsulated MOFs were thoroughly characterised, and their biological activity was assessed in vitro. MTT cell viability assay indicated a higher IC50 value for MTX-loaded MOFs compared to free MTX in physiological conditions, albeit with a slower release profile. These findings suggest the potential of these MTX-loaded MOFs as an alternative avenue for formulation to mitigate side effects. Full article
(This article belongs to the Special Issue Advanced Applications of Metal-Organic Frameworks (MOFs))
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