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AppliedChem
Special Issues
Toxicometabolomics: Recent Advances and Future Trends
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Special Issue "Toxicometabolomics: Recent Advances and Future Trends"

A special issue of AppliedChem (ISSN 2673-9623).

Deadline for manuscript submissions: 30 September 2023 | Viewed by 4544

Special Issue Editors

Dr. Theodoros Chatzimitakos

E-Mail Website
Guest Editor
Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
Interests: nanomaterials; carbon-based nanomaterials; graphene; carbon nanodots; photoluminescent probes; sample preparation; analytical method development; metabolomics; toxicity; antibacterial activity
Special Issues, Collections and Topics in MDPI journals
Dr. Athanasia Kasouni

E-Mail Website
Guest Editor
Department of Biological Applications and Technologies, University of Ioannina, 45110 Ioannina, Greece
Interests: toxicity evaluation; therapeutic applications; wound healing; oxidative stress; anti-inflammatory activity; antimicrobial properties; carbon nanodots; bioimaging; metabolomics; medicinal plants

Special Issue Information

Dear Colleagues,

Knowledge of various compounds that pose a threat to human health, and that of (micro)organisms, is ever-increasing with scientific advancement. Research focusing solely on the effect of toxic compounds on various organisms is inadequate, with information on these effects at a molecular level urgently needed. Advanced analytical techniques have thus been employed to shed light on the alterations that take place in an organism’s metabolome, elucidating the relationship between phenotypic alterations and metabolome changes as well as disorders. We are pleased to invite you to contribute to this Special Issue to further advance the exponentially expanding field of metabolomics.

This Special Issue aims to review advances in the field of toxicometabolomics, as well as pave the way for future trends in this Research field.

Original Research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Toxicity evaluation for prokaryotes, eukaryotes, and more advanced organisms (e.g., animals);
  • Metabolic profiling after exposure to toxic compounds or nanomaterials;
  • Association between the phenotypic and metabolic alterations;
  • Development of new metabolomic techniques/approaches;
  • Metabolite identification techniques.

We look forward to receiving your contributions.

Dr. Theodoros Chatzimitakos
Dr. Athanasia Kasouni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. AppliedChem is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • toxicometabolomics
  • toxicology
  • high-resolution mass spectrometry
  • nuclear magnetic resonance spectroscopy
  • analytical techniques
  • metabolomic databases
  • metabolic pathways
  • untargeted metabolic profiling
  • quantitative metabolomics
  • prokaryotes
  • eukaryotes
  • organisms

Published Papers (2 papers)

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Review
Metabolomics Approach to Reveal the Effects of Ocean Acidification on the Toxicity of Harmful Microalgae: A Review of the Literature
by
Tsz-Ki Victoria Tsui
and
Hang-Kin Kong
AppliedChem 2023, 3(1), 169-195; https://doi.org/10.3390/appliedchem3010012 - 16 Mar 2023
Viewed by 1525
Abstract
Climate change has been associated with intensified harmful algal blooms (HABs). Some harmful microalgae produce toxins that accumulate in food webs, adversely affecting the environment, public health and economy. Ocean acidification (OA) is a major consequence of high anthropogenic CO2 emissions. The [...] Read more.
Climate change has been associated with intensified harmful algal blooms (HABs). Some harmful microalgae produce toxins that accumulate in food webs, adversely affecting the environment, public health and economy. Ocean acidification (OA) is a major consequence of high anthropogenic CO2 emissions. The carbon chemistry and pH of aquatic ecosystems have been significantly altered as a result. The impacts of climate change on the metabolisms of microalgae, especially toxin biosynthesis, remain largely unknown. This hinders the optimization of HAB mitigation for changed climate conditions. To bridge this knowledge gap, previous studies on the effects of ocean acidification on toxin biosynthesis in microalgae were reviewed. There was no solid conclusion for the toxicity change of saxitoxin-producing dinoflagellates from the genus Alexandrium after high CO2 treatment. Increased domoic acid content was observed in the diatom Pseudo-nitzschia. The brevetoxin content of Karenia brevis remained largely unchanged. The underlying regulatory mechanisms that account for the different toxicity levels observed have not been elucidated. Metabolic flux analysis is useful for investigating the carbon allocations of toxic microalgae under OA and revealing related metabolic pathways for toxin biosynthesis. Gaining knowledge of the responses of microalgae in high CO2 conditions will allow the better risk assessment of HABs in the future. Full article
(This article belongs to the Special Issue Toxicometabolomics: Recent Advances and Future Trends)
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Review
Endotoxins Affecting Human Health during Agricultural Practices: An Overview
by
B. Surya Kumar Chhetry
,
Krishna Narayan Dewangan
,
Dipendra Kumar Mahato
and
Pradeep Kumar
AppliedChem 2023, 3(1), 11-31; https://doi.org/10.3390/appliedchem3010002 - 22 Dec 2022
Viewed by 2102
Abstract
Agricultural operations and the processing sector generate dust laden with endotoxin in the workplace. Endotoxin, a pro-inflammatory agent, has adverse effects on health, especially in the lungs, as exposure to endotoxin reduces lung function capacity. Endotoxin exposure to workers and its harmful impact [...] Read more.
Agricultural operations and the processing sector generate dust laden with endotoxin in the workplace. Endotoxin, a pro-inflammatory agent, has adverse effects on health, especially in the lungs, as exposure to endotoxin reduces lung function capacity. Endotoxin exposure to workers and its harmful impact on the health of agricultural workers needs to be studied in detail for future interventions to reduce exposure to endotoxin. The review can help to identify the analytical methods used to determine endotoxin exposure in agriculture. A detailed study of the research articles published in the last two decades related to agriculture and allied fields was carried out. In the agricultural sector, Pantoea agglomerans, a Gram-negative bacterium, was predominantly present. The filters were stored at a temperature of −20 °C, and E. coli 055: B5 was the predominately used standard to analyze the endotoxin. The quantitative kinetic Limulus Amebocyte Lysate test was the most common detection method for quantifying endotoxin. Control strategies to reduce endotoxin exposure are also emphasized in this review. Full article
(This article belongs to the Special Issue Toxicometabolomics: Recent Advances and Future Trends)
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