The Role of Redox Signaling in Kidney Physiology and Kidney Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 18587
2. Department of Nephrology, Odense University Hospital, 5000 Odense, Denmark
Interests: chronic kidney disease; oxidative stress; antioxidants; vitamin D; cell signaling
Interests: mitochondria; reactive oxygen species; antioxidants
Special Issues, Collections and Topics in MDPI journals
Kidney diseases present a worldwide health problem and are associated with a high burden of morbidity and mortality. There is an urgent need for novel therapies, and redox-based therapeutic strategies (“redox medicine”) are regarded as promising tools to reduce the progression of renal decline and the development of kidney disease-related morbidity.
The kidney depends on redox signaling to realize its function and a considerable number of proteins are redox-sensitive. Both acute and chronic kidney disease are associated with an imbalance between antioxidants and oxidants that is in favour of the latter. The resulting state with molecular damage and/or a disturbance of the physiologic redox signaling is termed “oxidative stress”. Recent research has advanced our understanding of redox signaling in kidney disease states, but therapies targeting specific redox signaling pathways are not yet available for clinical routine. The search for therapeutic options is complicated by the inevitable requirement of efficient redox signaling as part of the physiological regulation in the kidney and in the body as a whole.
Therefore, we welcome submissions to a Special Issue entitled “The Role of Redox Signaling in Kidney Physiology and Kidney Disease”, to further advance our understanding in this area. Hopefully, this will help to pave the way for new therapeutic strategies in kidney diseases.
Dr. Alexandra Scholze
Prof. Dr. José Pedraza Chaverri
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- redox signaling
- oxidative stress
- kidney physiology
- kidney disease
- redox-based therapeutic strategies