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Special Issue "Oxidative Stress and Inflammation in the Pathogenesis of Colorectal Cancer: Preclinical and Clinical Evidences"

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A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 5292

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Special Issue Editors

Dr. Luís Fernando Barbisan

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Guest Editor

1. Department of Pathology, Botucatu Medical School, UNESP-São Paulo State University, Botucatu 18600-000, Brazil
2. Department of Structural and Functional Biology, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-689, São Paulo, Brazil
Interests: nutrition and liver diseases; hepatotoxicity; hepatocarcinogenesis; non-alcoholic fatty liver disease; chemoprevention
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Maria Aparecida Marchesan Rodrigues

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Department of Pathology, Botucatu Medical School, Sao Paulo State University (UNESP), Sao Paulo 19060-560, Brazil
Interests: colon carcinogenesis; oxidative stress; inflammation; chemoprevention

Prof. Dr. Guilherme Ribeiro Romualdo

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Guest Editor

1. Department of Pathology, Botucatu Medical School, UNESP-São Paulo State University, Botucatu 18600-000, Brazil
2. Department of Structural and Functional Biology, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-689, São Paulo, Brazil
Interests: hepatocarcinogenesis; non-alcoholic fatty liver disease; chemoprevention; immunotherapy; chemotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent data from the World Health Organization have identified colorectal cancer (CRC) as the fourth most commonly diagnosed neoplasia, as well as the third leading cause of cancer-related deaths worldwide. Several risk factors point to the onset and progression of CRC, such as “westernized” dietary habits, physical inactivity, smoking, alcohol abuse, and obesity, and a cross-talk between these known risk factors could lead to oxidative stress and inflammation with the overproduction of reactive oxygen species (ROS). Excessive ROS exposure on colonic epithelial cells could result in genomic instability and mutations—remarkable carcinogenesis hallmarks. Moreover, the occurrence of inflammatory bowel disease (IBD) has also been suggested to increase the risk of CRC, causing an extensive and persisting inflammatory reaction manifested by the upregulation of an array of pro-inflammatory mediators, such as nuclear factor kappa B (NFkB), cyclooxygenase 2 (COX-2), tumor necrosis factor α (TNF-α), transforming growth factor β (TGFβ), etc. These molecular factors critically contribute to the progression of the chronic inflammation–dysplasia–adenoma–carcinoma sequence. In contrast, clinical and preclinical studies have hinted at the importance of antioxidants and anti-inflammatory approaches in preventing colorectal tumorigenesis.

This Special Issue aims to reveal novel aspects of oxidative stress and inflammation on the pathogenesis of CRC, comprising both preclinical and clinical evidences, especially welcoming newly developed methodologies and mechanistic studies shedding light on the molecular landscape involved in the induction/promotion or prevention/treatment of CRC through the modulation of oxidative stress and inflammation.

We look forward to your contributions!

Prof. Dr. Luís Fernando Barbisan
Prof. Dr. Maria Aparecida Marchesan Rodrigues
Prof. Dr. Guilherme Ribeiro Romualdo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
inflammation
antioxidants and anti-inflammatory approaches
colorectal carcinogenesis
chemoprevention
biomarkers and prognosis

Published Papers (3 papers)

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Research

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Open AccessArticle

The Implications of Connexin 43 Deficiency during the Early Stages of Chemically Induced Mouse Colon Carcinogenesis

Sara Gomes Espírito Santo

Tereza Cristina da Silva

Mathieu Vinken

Bruno Cogliati

Luís Fernando Barbisan

and

Guilherme Ribeiro Romualdo

Antioxidants 2022, 11(12), 2368; https://doi.org/10.3390/antiox11122368 - 30 Nov 2022

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Abstract

Colorectal cancer (CRC), associated with an increased intake of processed red meats, saturated fats, and simple carbohydrates accompanied by low dietary fiber, fruits, and vegetables consumption, presents a high epidemiological burden. Connexin43 (Cx43) protein, which forms gap junctions or hemichannels, has tumor suppressor or oncogenic activities in a cancer type- and stage-dependent manner. Cx43 expression varies during colon carcinogenesis, and its functional role is not fully understood. Thus, we evaluated the implications of Cx43 heterologous deletion (Cx43^+/−) during the early stages of a chemically induced model of colon carcinogenesis. Female C57BL/6J mice (wild-type or Cx43^+/−) were submitted to a colon carcinogenesis model induced by 1,2 dimethylhydrazine (DMH). Mice were euthanized eight hours (week 7) or 30 weeks (week 37) after the last DMH administration to evaluate subacute colon toxicity outcomes or the burden of (pre)neoplastic lesions, respectively. At week 7, Cx43 deficiency inferred no alterations in the DMH-induced increase in systemic (peripheral blood), in situ (colonocytes) DNA damage, and apoptosis in the colonocytes. At week 30, Cx43^+/− mice presented an increase in preneoplastic aberrant crypt foci (ACF) multiplicity, while no alterations were observed in colorectal adenoma (CRA) occurrence, multiplicity, volume, proliferation, growth, and β-catenin immunoexpression. Similarly, an in silico analysis of human CRA showed decreased mRNA expression of Cx43 with no correlation with proliferation, apoptosis, and β-catenin markers. These findings indicate the discrete role of Cx43 in the early stages of chemically induced mouse colon carcinogenesis. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation in the Pathogenesis of Colorectal Cancer: Preclinical and Clinical Evidences)

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Open AccessArticle

Conductive Gas Plasma Treatment Augments Tumor Toxicity of Ringer’s Lactate Solutions in a Model of Peritoneal Carcinomatosis

Lea Miebach

Eric Freund

Alessandra Lourenço Cecchini

and

Sander Bekeschus

Antioxidants 2022, 11(8), 1439; https://doi.org/10.3390/antiox11081439 - 25 Jul 2022

Cited by 4 | Viewed by 1414

Abstract

Reactive species generated by medical gas plasma technology can be enriched in liquids for use in oncology targeting disseminated malignancies, such as metastatic colorectal cancer. Notwithstanding, reactive species quantities depend on the treatment mode, and we recently showed gas plasma exposure in conductive modes to be superior for cancer tissue treatment. However, evidence is lacking that such a conductive mode also equips gas plasma-treated liquids to confer augmented intraperitoneal anticancer activity. To this end, employing atmospheric pressure argon plasma jet kINPen-treated Ringer’s lactate (oxRilac) in a CT26-model of colorectal peritoneal carcinomatosis, we tested repeated intraabdominal injection of such remotely or conductively oxidized liquid for antitumor control and immunomodulation. Enhanced reactive species formation in conductive mode correlated with reduced tumor burden in vivo, emphasizing the advantage of conduction over the free mode for plasma-conditioned liquids. Interestingly, the infiltration of lymphocytes into the tumors was equally enhanced by both treatments. However, significantly lower levels of interleukin (IL)4 and IL13 and increased levels of IL2 argue for a shift in intratumoral T-helper cell subpopulations correlating with disease control. In conclusion, our data argue for using conductively over remotely prepared plasma-treated liquids for anticancer treatment. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation in the Pathogenesis of Colorectal Cancer: Preclinical and Clinical Evidences)

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Review

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Open AccessReview

Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

Annamária Bardelčíková

Jindřich Šoltys

and

Ján Mojžiš

Antioxidants 2023, 12(4), 901; https://doi.org/10.3390/antiox12040901 - 09 Apr 2023

Cited by 8 | Viewed by 2262

Abstract

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in the initiation and development of CRC. Although OS plays a vital part in the life of all organisms, its long-term effects on the human body may be involved in the development of different chronic diseases, including cancer diseases. Chronic OS can lead to the oxidation of biomolecules (nucleic acids, lipids and proteins) or the activation of inflammatory signaling pathways, resulting in the activation of several transcription factors or the dysregulation of gene and protein expression followed by tumor initiation or cancer cell survival. In addition, it is well known that chronic intestinal diseases such as inflammatory bowel disease (IBD) are associated with an increased risk of cancer, and a link between OS and IBD initiation and progression has been reported. This review focuses on the role of oxidative stress as a causative agent of inflammation in colorectal cancer. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation in the Pathogenesis of Colorectal Cancer: Preclinical and Clinical Evidences)

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Special Issue "Oxidative Stress and Inflammation in the Pathogenesis of Colorectal Cancer: Preclinical and Clinical Evidences"

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