Submit to Antioxidants Review for Antioxidants Propose a Special Issue

Journal Menu

Journal Browser

Special Issue "Oxidative Stress in Autoimmune Diseases"

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 2848

Share This Special Issue

Special Issue Editors

Prof. Dr. Gian Luca Erre

E-Mail Website
Guest Editor

1. Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
2. Dipartimento di Specialità Mediche, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
Interests: autoantibodies; rheumatic Diseases; clinical rheumatology; rheumatoid arthritis; systemic lupus erythematosus

Prof. Dr. Arduino A. Mangoni

E-Mail Website
Guest Editor

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedfor Park, SA 5042, Australia
Interests: drug and biomarker discovery; drug repurposing; aging; cancer; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

Dr. Gianfranco Pintus

E-Mail Website
Guest Editor

1. Professor of Biochemistry, Department of Medical Laboratory Sciences, University of Sharjah, P. O. Box 27272 Sharjah, United Arab Emirates
2. Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Interests: vascular biology; natural antioxidants; tissue remodeling; oxidative stress; redox-regulated signaling; molecular toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress may alter the functioning of the innate and adaptative immune response due to the aberrant production of reactive oxygen species and disrupted redox signaling. The dysfunctional innate and adaptative immune response resulting from oxidative stress and chronic inflammation may critically drive the initiation and progression of several autoimmune diseases via the production of pro-inflammatory cytokines, growth factors, and specific autoantibodies. Oxidative stress is a well-known hallmark of different autoimmune disorders, including rheumatologic systemic diseases (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis), neurologic disorders (multiple sclerosis), chronic inflammatory bowel diseases (Crohn’s disease, ulcerative colitis), skin diseases (psoriasis), and autoimmune-related endothelial dysfunction and atherosclerosis.

This Special Issue of Antioxidants will focus on pre-clinical and clinical evidence highlighting the central role of oxidative stress and antioxidant pathways in the initiation and progression of autoimmune diseases. We invite the submission of basic, translational, and clinical research studies reporting relevant changes in the levels or activities of redox proteins, thiols, and/or the altered redox states of particular proteins in autoimmune diseases, as well as the impact of oxidative stress on inflammatory pathways, autoimmune response, tissue fibrosis, and endothelial dysfunction. In addition, this Special Issue welcomes papers on promising druggable targets for clinical use. Review articles discussing the current state of the art are also welcome.

Prof. Dr. Gian Luca Erre
Prof. Dr. Arduino Mangoni
Prof. Dr. Gianfranco Pintus
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

antioxidant
oxidative stress
autoimmune diseases
rheumatological diseases
autoimmune skin disorders
bowel diseases
multiple sclerosis
reactive oxygen species
cell signaling

Published Papers (3 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Other

Open AccessArticle

Malondialdehyde Serum Levels in Patients with Systemic Sclerosis Relate to Dyslipidemia and Low Ventricular Ejection Fraction

Candelaria Martín-González

Miguel Á. González-Gay

and

Iván Ferraz-Amaro

Antioxidants 2023, 12(9), 1668; https://doi.org/10.3390/antiox12091668 - 25 Aug 2023

Viewed by 484

Abstract

Systemic sclerosis (SSc) is a chronic disease characterized by vasculopathy with the involvement of dysfunctional microcirculatory vessels. Features of the disease include progressive fibrosis of the skin and internal organs and systemic inflammation characterized by the presence of circulating autoantibodies and proinflammatory cytokines. Furthermore, macrovascular disease and atherosclerosis are more common in patients with SSc than in the general population. Oxidative stress plays a crucial role in the development of several processes, including endothelial dysfunction, cancer, inflammation, and atherogenesis. Malondialdehyde (MDA) is a well-established marker of oxidative stress. In this work, we have analyzed the relationship between serum MDA levels and clinical, laboratory, and vascular characteristics in a well-characterized cohort of 53 patients with SSc. A multivariable analysis was performed to study the relationship between circulating MDA and disease characteristics in patients with SSc. Cardiovascular assessment was also performed, including ultrasonography of the carotid and aorta, and echocardiography. MDA showed a significant and positive relationship with the serum levels of lipid profile molecules such as total cholesterol (β coefficient = 0.006 (95% CI: 0.0004 to 0.01), nmol/mL, p = 0.037) and LDL cholesterol (β coefficient = 0.008 (95% CI: 0.001 to 0.01) nmol/mL, p = 0.017). On the contrary, most manifestations of the disease, including skin, lung, and joint involvement, as well as the presence of digital ulcers, were not related to MDA. However, high MDA levels were significantly and independently associated with lower ventricular ejection fraction after adjustment for covariates (β coefficient = −0.04 (95% CI: −0.06 to −0.02), nmol/mL, p = 0.001). In conclusion, serum MDA levels were related to higher levels of total and LDL cholesterol and a lower left ventricular ejection fraction in patients with SSc. MDA could serve as a potential biomarker of dyslipidemia and heart failure in SSc. Full article

(This article belongs to the Special Issue Oxidative Stress in Autoimmune Diseases)

Open AccessArticle

Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus

Nayra Merino de Paz

María García-González

Fuensanta Gómez-Bernal

Juan C. Quevedo-Abeledo

Antonia de Vera-González

Raquel López-Mejias

Pedro Abreu-González

Candelaria Martín-González

Miguel Á. González-Gay

and

Iván Ferraz-Amaro

Antioxidants 2023, 12(8), 1535; https://doi.org/10.3390/antiox12081535 - 31 Jul 2023

Viewed by 606

Abstract

Malondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. Oxidative stress has been observed to be increased in systemic lupus erythematosus (SLE). Some studies have shown that MDA is upregulated in SLE compared to controls. However, the literature lacks reports regarding the relationship of MDA to disease manifestations. This is relevant since SLE is a multisystemic disease which may affect virtually any organ in the body. In this study, we set out to analyze how MDA serum levels are associated with disease expression in a large series of SLE patients who were fully characterized in clinical and laboratory terms. A total of 284 patients with SLE were recruited. Serum levels of MDA, and the activity (SLEDAI), severity (Katz) and damage index (SLICC-DI) scores, full lipid profile, and carotid subclinical atherosclerosis were assessed. In addition, a full characterization of the complement system was performed in SLE patients’ samples. Multivariable linear regression analysis was executed to study the relationship between clinical and laboratory disease characteristics and MDA. A statistically significant negative relationship was found between disease duration and MDA. In contrast, the presence of anti-nucleosome antibodies was positively associated with MDA. Regarding the SLICC-DI areas, both the musculoskeletal domain and the cutaneous domain were significantly related to higher serum MDA values. Furthermore, after adjustment for confounding factors, lower levels of the classical complement pathway, which denotes activation, were associated with higher serum levels of MDA. In conclusion, cumulative musculoskeletal and skin damage in SLE patients is associated with superior serum levels of MDA. In addition, activation of the complement system is also related to higher circulating MDA levels. Full article

(This article belongs to the Special Issue Oxidative Stress in Autoimmune Diseases)

► Show Figures

Figure 1

Other

Jump to: Research

Open AccessSystematic Review

Association between Paraoxonase/Arylesterase Activity of Serum PON-1 Enzyme and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

and

Antioxidants 2022, 11(12), 2317; https://doi.org/10.3390/antiox11122317 - 23 Nov 2022

Cited by 2 | Viewed by 984

Abstract

Background: A decrease in serum paraoxonase (PON-1) and arylesterase (ARE) activity has been reported in rheumatoid arthritis (RA) patients and linked to chronic inflammation and impaired antioxidant defense. Methods: A systematic review and meta-analysis were performed to critically appraise the current evidence on plasma/serum concentrations of PON-1 and ARE activity in RA patients and healthy controls. The Web of Science, PubMed, Scopus, and Google Scholar databases were searched from inception to November 2021. We used random-effects meta-analysis. The risk of bias was estimated using the Joanna Briggs Institute Critical Appraisal Checklist tool. The certainty of the evidence was assessed with GRADE. The study complied with the PRISMA statements and was registered in PROSPERO (CRD42022345380). Results: Seventeen studies reported PON-1 activity (1144 RA patients, 797 controls) and ten reported ARE activity (1367 RA patients, 1037 controls). RA patients had significantly lower PON-1 (SMD = −1.32, 95% CI −1.94 to −0.70; p < 0.001) and ARE activity (SMD = −0.91, 95% CI −1.37 to −0.46; p < 0.001). There was substantial heterogeneity (PON, I2 97%; ARE, 95.7%, p < 0.001 for both). There was no publication bias. The pooled SMD values did not significantly change after sensitivity analysis. The certainty of the evidence was very low due to the observational nature of the studies and the large heterogeneity. Conclusion: Our meta-analysis has shown that both serum PON-1 and ARE activity are significantly lower in RA patients, suggesting a deficit in antioxidant defense mechanisms in this disease. Full article

(This article belongs to the Special Issue Oxidative Stress in Autoimmune Diseases)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Oxidative Stress in Autoimmune Diseases"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (3 papers)

Research

Other

Further Information

Guidelines

MDPI Initiatives

Follow MDPI