The Role of Oxidative Stress and Antioxidant Systems in Oral Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3924

Special Issue Editors

Department of Disaster Related Oral Health, Oxidative Stress/ESR Laboratories, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan
Interests: reactive oxygen species; oxidative stress; antioxidant; electron spin resonance (ESR); oral health; oral disease
Department of Dentistry for the Special Patient, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan
Interests: periodontitis; Down syndrome; oxidative stress; antioxidant; oral care and frailty for special patients

Special Issue Information

Dear Colleagues,

Oxidative stress, caused by reactive oxygen species (ROS), is considered a major cause of various diseases in the medical field, including lifestyle-related diseases, dementia, and cancer. In dentistry, ROS are implicated in periodontal disease, one of the two major dental diseases, and have long been used as root canal disinfectants in clinical dentistry. However, oxidative stress and antioxidant systems are still not included in mainstream dental research. To overcome this situation, this Special Issue of " The Role of Oxidative stress and Antioxidant systems in Oral Health" will collate the results of research on oxidative stress and antioxidant systems related to oral health, dental diseases, and dental treatment. In this Special Issue, we would like to report on the involvement of oxidative stress and antioxidant systems in major oral diseases, such as periodontal disease, xerostomia, stomatitis, and oral cancer, and to include the latest research reports on the involvement of reactive oxygen species in the osseointegration of titanium used in oral implant therapy and the safety of radical polymerization in dental adhesives. Furthermore, in the "100-year life age," we hope to publish research that demonstrates the importance of oral function based on the interaction between higher brain function and oral antioxidant effects, in order to achieve healthy longevity even in old age, as well as research that prevents the negative chain of events, which leads to low nutrition and sarcopenia in the elderly and disabled through future-type dental nutrition collaboration. The research on oral oxidative stress and antioxidant assessments related to oral frailty and frailness, as well as the development of oral health care products through industry–academia collaborations, should also be included.

We would like to make this a Special Issue that communicates the clear message of bringing about groundbreaking dental innovations through basic and applied research on oxidative stress and antioxidant systems in dentistry and ROS, and we look forward to your contributions.

Prof. Dr. Masaichi-Chang-il Lee
Dr. Tomoko Komatsu
Guest Editors

Manuscript Submission Information

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Keywords

  • oral health
  • oral disease
  • oral function
  • Reactive oxygen species
  • oxidative stress
  • antioxidants
  • periodontitis
  • Down syndrome
  • saliva
  • electron spin resonance (ESR)

Published Papers (2 papers)

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Research

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17 pages, 4674 KiB  
Article
Development and Characterization of Microparticles with Actinidia arguta Leaves Extract by Spray-Drying: A New Mind-Set Regarding Healthy Compounds for Oral Mucositis
by Filipa Teixeira, Ana Margarida Silva, Stefania Sut, Stefano Dall’Acqua, Cristina Delerue-Matos, Berta Estevinho, Paulo C. Costa and Francisca Rodrigues
Antioxidants 2023, 12(8), 1496; https://doi.org/10.3390/antiox12081496 - 26 Jul 2023
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Abstract
Actinidia arguta leaves have gained notoriety over the past years due to their rich bioactive composition with human pro-healthy effects, particularly in relation to antioxidants. Nevertheless, antioxidants are well known for their chemical instability, making it necessary to develop suitable delivery systems, such [...] Read more.
Actinidia arguta leaves have gained notoriety over the past years due to their rich bioactive composition with human pro-healthy effects, particularly in relation to antioxidants. Nevertheless, antioxidants are well known for their chemical instability, making it necessary to develop suitable delivery systems, such as microparticles, to provide protection and ensure a controlled release. The aim of this work was to produce polymeric particles of A. arguta leaves extract by spray-drying that may improve the oral mucositis condition. Microparticles were characterized by size, shape, antioxidant/antiradical activities, swelling capacity, moisture content, and effect on oral cells (TR146 and HSC-3) viability, with the aim to assess their potential application in this oral condition. The results attested the microparticles’ spherical morphology and production yields of 41.43% and 36.40%, respectively, for empty and A. arguta leaves extract microparticles. The A. arguta leaves extract microparticles obtained the highest phenolic content (19.29 mg GAE/g) and antioxidant/antiradical activities (FRAP = 81.72 µmol FSE/g; DPPH = 4.90 mg TE/g), being perceived as an increase in moisture content and swelling capacity. No differences were observed between empty and loaded microparticles through FTIR analysis. Furthermore, the exposure to HSC-3 and TR146 did not lead to a viability decrease, attesting their safety for oral administration. Overall, these results highlight the significant potential of A. arguta leaves extract microparticles for applications in the pharmaceutical and nutraceutical industries. Full article
(This article belongs to the Special Issue The Role of Oxidative Stress and Antioxidant Systems in Oral Health)
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Review

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23 pages, 1667 KiB  
Review
Benefits of Natural Antioxidants on Oral Health
by Giuseppina Malcangi, Assunta Patano, Anna Maria Ciocia, Anna Netti, Fabio Viapiano, Irene Palumbo, Irma Trilli, Mariafrancesca Guglielmo, Alessio Danilo Inchingolo, Gianna Dipalma, Francesco Inchingolo, Elio Minetti and Angelo Michele Inchingolo
Antioxidants 2023, 12(6), 1309; https://doi.org/10.3390/antiox12061309 - 20 Jun 2023
Cited by 3 | Viewed by 2220
Abstract
In recent years, special attention has been paid to the correlation between oxidation–reduction mechanisms and human health. The free radicals produced via physiological cellular biochemical processes are major contributors to oxidation phenomena. Their instability is the major cause of cellular damage. Free radical [...] Read more.
In recent years, special attention has been paid to the correlation between oxidation–reduction mechanisms and human health. The free radicals produced via physiological cellular biochemical processes are major contributors to oxidation phenomena. Their instability is the major cause of cellular damage. Free radical reactive oxygen species containing oxygen are the best-known ones. The body neutralises the harmful effects of free radicals via the production of endogenous antioxidants (superoxide dismutase, catalase, glutathione, and melatonin). The field of study of nutraucetics has found antioxidant capacity in substances such as vitamins A, B, C, E, coenzyme Q-10, selenium, flavonoids, lipoic acid, carotenoids, and lycopene contained in some foods. There are several areas of investigation that aim to research the interaction between reactive oxygen species, exogenous antioxidants, and the microbiota to promote increased protection via the peroxidation of macromolecules (proteins, and lipids) by maintaining a dynamic balance among the species that make up the microbiota. In this scoping review, we aim to map the scientific literature on oxidative stress related to the oral microbiota, and the use of natural antioxidants to counteract it, to assess the volume, nature, characteristics, and type of studies available to date, and to suggest the possible gaps that will emerge from the analysis. Full article
(This article belongs to the Special Issue The Role of Oxidative Stress and Antioxidant Systems in Oral Health)
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