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Special Issue "Nanoantioxidants Volume II"

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A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 December 2023 | Viewed by 3660

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Dr. Riccardo Amorati

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Department of Chemistry “G. Ciamician”, University of Bologna, Via San Giacomo 11, 40126 Bologna, Italy
Interests: nanoantioxidants; methods to measure antioxidant activity; mechanistic aspects of antioxidant activity; computational chemistry; kinetics of radical reactions
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Special Issue Information

Dear Colleagues,

Natural and engineered nanomaterials represent one of the most promising frontiers in the field of antioxidants. Natural-based biocompatible nanomaterials such as metal oxides, melanins, and lignin nanoparticles have demonstrated the possibility to act as radical scavengers with low toxicity. The possibility to easily functionalize the surface of nano-objects opens interesting applications such as modulation of the solubility and targeting.

The mechanisms of action that have been uncovered so far are the quenching of free radicals, and SOD – CAT – GPx enzyme-like behavior. The activity can be either intrinsic (such as in CeO₂ nanoparticles) or due to the covalent binding of small-molecule antioxidants to the surface. Nanomaterials can also reduce lipid peroxidation by reducing photoinitiation by absorbing UV-vis radiation. Another important field that is experiencing exponential growth is the use of nanocarriers (lipid particles, nanocapsules, nanotubes, etc.) to improve small-molecule antioxidant solubility and sustained release.

This Special Issue aims to collect recent developments in the field of the radical chemistry of nano-antioxidants, with a special focus on this non-exhaustive list of topics:

1) Preparation of novel nanomaterials having antioxidant activity;
2) Studies of the interaction of nanomaterials with free radicals, and ROS in general, with a special focus on alkylperoxyl radicals that propagate the lipid peroxidation;
3) Nanocarriers or nanocapsules for targeted transport and controlled release of antioxidants;
4) Biomimetic methods for measuring the efficacy of nanoantioxidants.

Dr. Riccardo Amorati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Research

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Open AccessArticle

Safe-Shields: Basal and Anti-UV Protection of Human Keratinocytes by Redox-Active Cerium Oxide Nanoparticles Prevents UVB-Induced Mutagenesis

Francesca Corsi

Erika Di Meo

Daniela Lulli

Greta Deidda Tarquini

Cristina Maria Failla

and

Lina Ghibelli

Antioxidants 2023, 12(3), 757; https://doi.org/10.3390/antiox12030757 - 20 Mar 2023

Cited by 1 | Viewed by 898

Abstract

Cerium oxide nanoparticles (nanoceria), biocompatible multifunctional nanozymes exerting unique biomimetic activities, mimic superoxide-dismutase and catalase through a self-regenerating, energy-free redox cycle driven by Ce^3+/4+ valence switch. Additional redox-independent UV-filter properties render nanoceria ideal multitask solar screens, shielding from UV exposure, simultaneously protecting tissues from UV-oxidative damage. Here, we report that nanoceria favour basal proliferation of primary normal keratinocytes, and protects them from UVB-induced DNA damage, mutagenesis, and apoptosis, minimizing cell loss and accelerating recovery with flawless cells. Similar cell-protective effects were found on irradiated noncancerous, but immortalized, p53-null HaCaT keratinocytes, with the notable exception that here, nanoceria do not accelerate basal HaCaT proliferation. Notably, nanoceria protect HaCaT from oxidative stress induced by irradiated titanium dioxide nanoparticles, a major active principle of commercial UV-shielding lotions, thus neutralizing their most critical side effects. The intriguing combination of nanoceria multiple beneficial properties opens the way for smart and safer containment measures of UV-induced skin damage and carcinogenesis. Full article

(This article belongs to the Special Issue Nanoantioxidants Volume II)

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Open AccessArticle

Nanoemulsions of Clove Oil Stabilized with Chitosan Oleate—Antioxidant and Wound-Healing Activity

Sara Perteghella

Alice Garzoni

Alessandro Invernizzi

Milena Sorrenti

Cinzia Boselli

Antonia Icaro Cornaglia

and

Maria Cristina Bonferoni

Antioxidants 2023, 12(2), 273; https://doi.org/10.3390/antiox12020273 - 26 Jan 2023

Cited by 2 | Viewed by 1173

Abstract

Clove oil (CO) is a powerful antioxidant essential oil (EO) with anti-inflammatory, anesthetic, and anti-infective properties. It can be therefore considered a good candidate for wound-healing applications, especially for chronic or diabetic wounds or burns, where the balance of reactive oxygen species (ROS) production and detoxification is altered. However, EOs require suitable formulations to be efficiently administered in moist wound environments. Chitosan hydrophobically modified by an ionic interaction with oleic acid (chitosan oleate, CSO) was used in the present work to stabilize CO nanoemulsions (NEs). The dimensions of the NE were maintained at around 300 nm as the volume distribution for up to six months, and the CO content did not decrease to under 80% over 4 months, confirming the good stabilizing properties of CSO. The antioxidant properties of the CO NE were evaluated in vitro by a 2,2-diphenil-2-picrylhydrazyl hydrate (DPPH) assay, and in fibroblast cell lines by electron paramagnetic resonance (EPR) using α-phenyl-N-tert-butyl nitrone (PBN) as a spin trap; a protective effect was obtained comparable to that obtained with α-tocopherol treatment. In a murine burn model, the ability of CO formulations to favor macroscopic wound closure was evidenced, and a histological analysis revealed a positive effect of the CO NE on the reparation of the lesion after 18 days. Samples of wounds at 7 days were subjected to a histological analysis and parallel dosage of lipid peroxidation by means of a thiobarbituric acid-reactive substances (TBARS) assay, confirming the antioxidant and anti-inflammatory activity of the CO NE. Full article

(This article belongs to the Special Issue Nanoantioxidants Volume II)

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Review

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Open AccessReview

On the Importance of the Starting Material Choice and Analytical Procedures Adopted When Developing a Strategy for the Nanoencapsulation of Saffron (Crocus sativus L.) Bioactive Antioxidants

Maria Z. Tsimidou

Antioxidants 2023, 12(2), 496; https://doi.org/10.3390/antiox12020496 - 16 Feb 2023

Viewed by 1094

Abstract

Saffron is known as the most expensive spice in the world. It is comprised of the dried stigmas of the pistil of the Crocus sativus L., which is a cultivated, sterile crocus plant. This plant material is now recognized as the unique edible source of certain bioactive apocarotenoids for which in-vivo antioxidant properties have been reported. Among the latter, crocins, red-orange natural colorants, and their parent molecule crocetin prevail in bioactivity significance. This review is focused on the strategies developed so far for their nanoencapsulation in relation to the characteristics of the starting material, extraction procedures of the bioactive antioxidants and analytical methods applied for their characterization and quantification throughout the process. The literature so far points out gaps that lead to publishable data, on one hand, but not necessarily to repeatable and meaningful processes due to incomplete characterization of the starting and the released material in efficiency and stability studies of the nanoencapsulates. Accurate terminology and quantitative chromatographic or spectrophotometric procedures for the determination of the core compounds are needed. Authenticity control and quality of saffron samples, and the verification of the concentrations of compounds in commercial preparations labeled as ‘crocin,’ are prerequisites in any experimental design setup. Full article

(This article belongs to the Special Issue Nanoantioxidants Volume II)

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