Dear Colleagues,

Metabolic syndrome, characterized by a constellation of conditions including obesity, insulin resistance, dyslipidemia, and hypertension, presents a significant public health challenge worldwide. Emerging research suggests that oxidative stress, exacerbated by alterations in gut microbiota composition and function, plays a pivotal role in the pathogenesis and progression of metabolic syndrome. Oxidative stress arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, contributing to cellular damage, inflammation, and metabolic dysfunction.

This Special Issue aims to deepen our understanding of the intricate interplay between gut microbiota, oxidative stress, and metabolic syndrome. We invite original research articles, reviews, and meta-analyses exploring various aspects of oxidative stress in the context of metabolic syndrome, specifically focusing on the gut microbiota. Topics of interest include, but are not limited to:

• Mechanisms linking gut dysbiosis to oxidative stress and the development of metabolic syndrome;
• The role of gut microbiota-derived metabolites in modulating oxidative stress pathways and metabolic dysfunction;
• The impact of gut-barrier integrity and intestinal permeability on oxidative stress and metabolic syndrome;
• Interactions between gut microbiota, dietary factors, and host metabolism in shaping oxidative stress profiles in metabolic syndrome;
• Therapeutic strategies targeting gut microbiota and oxidative stress for the prevention and management of metabolic syndrome complications.

Furthermore, we welcome studies investigating the efficacy of interventions to modulate gut microbiota composition and reduce oxidative stress burden in individuals with metabolic syndrome, including dietary modifications, prebiotics, probiotics, synbiotics, and fecal microbiota transplantation.

Researchers are encouraged to submit manuscripts that provide insights into the complex interactions between gut microbiota, oxidative stress, and metabolic syndrome and offer potential avenues for therapeutic intervention. Studies involving human subjects, animal models, and in vitro experimentation are all within the scope of this Special Issue.

We invite you to contribute to this important discussion by submitting your high-quality research to this Special Issue. Together, we can advance our understanding of gut microbiota-mediated oxidative stress in metabolic syndrome and pave the way for novel preventive and therapeutic strategies.

Prof. Dr. Sunmin Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.