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Antioxidants
Special Issues
Oxidative Stress in Environmental Toxicology
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Oxidative Stress in Environmental Toxicology

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 10821

Special Issue Editor

Prof. Dr. Ying Guo

E-Mail Website
Guest Editor
Shool of Environment, Jinan University, Guangzhou 510632, China
Interests: biomonitoring; exposome; environmental endocrine disruptors; metabonomics; exposure sciece; environmental fate of organic pollutants

Special Issue Information

Dear Colleagues,

Most human chronic diseases are linked to environmental exposure, including exposure to chemicals. Both toxicology and epidemiology studies have demonstrated that oxidative stress is a possible mechanism. For example, exposure to environmental pollutants may be involved in the production or elimination of reactive oxygen species in biota, and links between levels of oxidative stress and pollutants are often observed. Therefore, monitoring environmental exposure and oxidative stress is essential to evaluate the related potential health risk upon exposure.

This Special Issue aims to collect papers regarding recent developments in exposure studies involving oxidative stress. Studies including (but are not limited to) biomarkers of oxidative stress and chemical exposure, mechanisms involving oxidative stress and co-exposure of chemicals and/or environments, or contributor analysis of environment and biota are welcome.

Prof. Dr. Ying Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental exposure
  • oxidative stress
  • biomarker
  • chemical toxicities
  • health risk assessment

Published Papers (5 papers)

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Research

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21 pages, 9000 KiB  
Article
Effects of Prometryn Exposure on Hepatopancreas Oxidative Stress and Intestinal Flora in Eriocheir sinensis (Crustacea: Decapoda)
by Peng Huang, Liping Cao, Jinliang Du, Jiancao Gao, Yuning Zhang, Yi Sun, Quanjie Li, Zhijuan Nie and Gangchun Xu
Antioxidants 2023, 12(8), 1548; https://doi.org/10.3390/antiox12081548 - 02 Aug 2023
Cited by 4 | Viewed by 1191
Abstract
There is growing evidence that long-term exposure to prometryn (a widely used herbicide) can induce toxicity in bony fish and shrimp. Our previous study demonstrated its 96 h acute toxicity on the crab Eriocheir sinensis. However, studies on whether longer exposure to [...] Read more.
There is growing evidence that long-term exposure to prometryn (a widely used herbicide) can induce toxicity in bony fish and shrimp. Our previous study demonstrated its 96 h acute toxicity on the crab Eriocheir sinensis. However, studies on whether longer exposure to prometryn with a lower dose induces toxicity in E. sinensis are scarce. Therefore, we conducted a 20 d exposure experiment to investigate its effects on the hepatopancreas and intestine of E. sinensi. Prometryn reduce the activities of antioxidant enzymes, increase the level of lipid peroxidation and cause oxidative stress. Moreover, long-term exposure resulted in immune and detoxification fatigue, while short-term exposure to prometryn could upregulate the expression of genes related to immunity, inflammation and detoxification. Prometryn altered the morphological structure of the hepatopancreas (swollen lumen) and intestine (shorter intestinal villi, thinner muscle layer and thicker peritrophic membrane). In addition, prometryn changed the species composition of the intestinal flora. In particular, Bacteroidota and Proteobacteria showed a dose-dependent decrease accompanied by a dose-dependent increase in Firmicutes at the phylum level. At the genus level, all exposure groups significantly increased the abundance of Zoogloea and a Firmicutes bacterium ZOR0006, but decreased Shewanella abundance. Interestingly, Pearson correlation analysis indicated a potential association between differential flora and hepatopancreatic disorder. Phenotypic abundance analysis indicated that changes in the gut flora decreased the intestinal organ’s resistance to stress and increased the potential for opportunistic infection. In summary, our research provides new insights into the prevention and defense strategies in response to external adverse environments and contributes to the sustainable development of E. sinensis culture. Full article
(This article belongs to the Special Issue Oxidative Stress in Environmental Toxicology)
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24 pages, 12489 KiB  
Article
Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer
by Nelly D. Saenen, Margo S. Witters, Inneke Hantoro, Inés Tejeda, Anitha Ethirajan, Frank Van Belleghem and Karen Smeets
Antioxidants 2023, 12(3), 739; https://doi.org/10.3390/antiox12030739 - 17 Mar 2023
Cited by 2 | Viewed by 2534
Abstract
Currently, we lack crucial knowledge on how the physicochemical properties of particles affect cellular health, resulting in an important gap in our understanding of the human toxicity of microplastics (MPs). Our aim was to evaluate the impact of the size and the shape [...] Read more.
Currently, we lack crucial knowledge on how the physicochemical properties of particles affect cellular health, resulting in an important gap in our understanding of the human toxicity of microplastics (MPs). Our aim was to evaluate the impact of the size and the shape of MPs on uptake and the intracellular effects in a human epithelial colorectal adenocarcinoma (Caco-2) cell line. Spherical (200 nm and 2 µm) and fibre-/fragment-shaped (8.9 ± 10.1 µm by 1.14 ± 0.97 µm) polystyrene microplastics (PS-MPs) were used to study their uptake and the potential to induce redox and mitochondrial stress responses after 24 h of exposure. We demonstrated the cellular uptake of both spherical and fibre-/fragment-shaped MPs in a size-dependent manner. In response to 2 µm spheres, we observed differential expressions of redox-related genes, including HMOX1, CAT, and GPX1. All PS-MPs decreased the intracellular H2O2 levels, which can be attributed to mitochondrial stress responses, such as increased mitochondrial DNA content, footprint, and morphology. Altogether, we demonstrated uptakes and changes in redox and mitochondrial parameters for all PS-MPs, with the 200 nm spheres showing the most profound effects. This suggests that the induction of defensive responses in Caco-2 cells mainly correlates with the number of particles taken up. Full article
(This article belongs to the Special Issue Oxidative Stress in Environmental Toxicology)
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24 pages, 4658 KiB  
Article
Antioxidant Defense in Primary Murine Lung Cells following Short- and Long-Term Exposure to Plastic Particles
by Anke Schmidt, Melissa Mühl, Walison Augusto da Silva Brito, Debora Singer and Sander Bekeschus
Antioxidants 2023, 12(2), 227; https://doi.org/10.3390/antiox12020227 - 18 Jan 2023
Cited by 4 | Viewed by 1528
Abstract
Polystyrene nano- and micro-sized plastic particles (NMP) are one of the common plastic materials produced that dramatically pollute the environment, water, and oceanic habitats worldwide. NMP are continuously absorbed by the body through a number of routes, especially via intestinal ingestion, dermal uptake, [...] Read more.
Polystyrene nano- and micro-sized plastic particles (NMP) are one of the common plastic materials produced that dramatically pollute the environment, water, and oceanic habitats worldwide. NMP are continuously absorbed by the body through a number of routes, especially via intestinal ingestion, dermal uptake, and inhalation into the lung. Several studies provided evidence of NMP provoking oxidative stress and affecting cellular responses. Yet, the NMP effects on primary lung cells have not been studied. To this end, we isolated and cultured murine lung cells and exposed them short-term or long-term to polystyrene 0.2–6.0 µm-sized NMP. We studied cellular consequences regarding oxidative stress, morphology, and secretion profiling. Visualization, distribution, and expression analyses confirmed lung cells accumulating NMP and showed several significant correlations with particle size. Moreover, we found substantial evidence of biological consequences of small-scale NMP uptake in lung cells. Besides alterations of cytokine secretion profiles resulting in inflammatory responses, indicators of oxidative stress were identified that were accompanied by Nrf2 and β-catenin signaling changes. Our results serve as an important basis to point out the potential hazards of plastic contaminations and uptake in lung cells. Full article
(This article belongs to the Special Issue Oxidative Stress in Environmental Toxicology)
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8 pages, 648 KiB  
Article
The Enzymatic Antioxidants Activities Changes in Water Plants Tissues Exposed to Chlorpyrifos Stress
by Elżbieta Sobiecka, Milena Mroczkowska and Tomasz P. Olejnik
Antioxidants 2022, 11(11), 2104; https://doi.org/10.3390/antiox11112104 - 25 Oct 2022
Cited by 1 | Viewed by 1321
Abstract
Water pollution is an immense environmental problem, and plant protection products are part of it. The organophosphorus insecticides, chlorpyrifos as an example, were used for years, and their high concentration could negatively influence ecosystems. Some of the plants, such as macrophytes, were exposed [...] Read more.
Water pollution is an immense environmental problem, and plant protection products are part of it. The organophosphorus insecticides, chlorpyrifos as an example, were used for years, and their high concentration could negatively influence ecosystems. Some of the plants, such as macrophytes, were exposed to a variety of stress factors. To live on, the macrophytes developed an efficient antioxidative system consisting of enzymatic and non-enzymatic antioxidants. The remediation process of polluted water ecosystems caused by plant protection products in our climate zone can be intensified if it is provided by autochthonic macrophytes. The results of our studies are part of the research that allows optimizing the phytoremediation process without irreversible effect on investigated species. The influence of various concentrations of chlorpyrifos on the enzymatic system in Canadian waterweed (Elodea canadensis Michx.), needle spikerush (Eleocharis acicularis L.), and water mint (Mentha aquatica L.) were studied. The differences in values of guaiacol peroxidase (GPX) and glutathione S-transferase (GST) activities were determined in leaves and roots. Research indicated an increase in both enzyme activities in plants exposed to toxic compounds. The highest concentration of chlorpyrifos affected the highest activities of enzymes. The water mint roots responded with the highest value of glutathione S-transferase activity during cultivation in polluted environment. It was therefore concluded that an aqueous plant exposed to the toxic insecticide created a defensive mechanism by enzymatic antioxidant systems that correlated to the pollutant concentration and plant species. Full article
(This article belongs to the Special Issue Oxidative Stress in Environmental Toxicology)
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Review

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20 pages, 2044 KiB  
Review
Metal-Based Nanoparticles and Their Relevant Consequences on Cytotoxicity Cascade and Induced Oxidative Stress
by Yunhui Min, Godagama Gamaarachchige Dinesh Suminda, Yunji Heo, Mangeun Kim, Mrinmoy Ghosh and Young-Ok Son
Antioxidants 2023, 12(3), 703; https://doi.org/10.3390/antiox12030703 - 12 Mar 2023
Cited by 10 | Viewed by 3183
Abstract
Emerging nanoscience allows us to take advantage of the improved evolutionary components and apply today’s advanced characterization and fabrication techniques to solve environmental and biological problems. Despite the promise that nanotechnology will improve our lives, the potential risks of technology remain largely uncertain. [...] Read more.
Emerging nanoscience allows us to take advantage of the improved evolutionary components and apply today’s advanced characterization and fabrication techniques to solve environmental and biological problems. Despite the promise that nanotechnology will improve our lives, the potential risks of technology remain largely uncertain. The lack of information on bio-impacts and the absence of consistent standards are the limitations of using metal-based nanoparticles (mNPs) for existing applications. To analyze the role played by the mNPs physicochemical characteristics and tactics to protect live beings, the field of nanotoxicology nowadays is focused on collecting and analyzing data from in vitro and in vivo investigations. The degree of reactive oxygen species (ROS) and oxidative stress caused by material nanoparticles (NPs) depends on many factors, such as size, shape, chemical composition, etc. These characteristics enable NPs to enter cells and interact with biological macromolecules and cell organelles, resulting in oxidative damage, an inflammatory response, the development of mitochondrial dysfunction, damage to genetic material, or cytotoxic effects. This report explored the mechanisms and cellular signaling cascades of mNPs-induced oxidative stress and the relevant health consequences. Full article
(This article belongs to the Special Issue Oxidative Stress in Environmental Toxicology)
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