Special Issue "Regulatory Effects of Curcumin"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 January 2024 | Viewed by 6277
Interests: vitamin E; curcumin; signal transduction; gene expression; senescence
Interests: food function; antioxidant; curcumin; lipid oxidation; oxidative stress
Curcumin, the main bioactive polyphenol present in the turmeric plant Curcuma longa, has beneficial effects for the treatment and prevention of several diseases. Whereas at high experimental concentrations, curcumin may act as antioxidant and affect multiple targets, recent research has revealed regulatory effects even at levels that can be reached by dietary supplementation, and the molecular mechanisms of action are beginning to be resolved. These studies indicate that curcumin and its metabolites may modulate several signal transduction and gene expression pathways by interacting with and affecting the activity of specific enzymes and proteins. Curcumin derivatives, novel pharmacological formulations, nanocarriers, and improved delivery systems have been developed that can enhance the otherwise relatively low bioavailability of curcumin and increase its bioactivity in the human body. During uptake from the diet, curcumin may also modulate the intestinal microbiome, leading to indirect regulatory effects.
In this Special Issue of Antioxidants, the molecular regulatory effects of curcumin are reviewed, and their relevance for the prevention of diseases such as cancer, inflammation, neurodegeneration, cognitive disorders, obesity, atherosclerosis, diabetes, dyslipidemia, and liver diseases such as non-alcoholic steatohepatitis (NASH) is evaluated.
Dr. Jean-Marc Zingg
Dr. Kiyotaka Nakagawa
Dr. Taiki Miyazawa
Manuscript Submission Information
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- Curcuma longa
- regulatory effects