Special Issue "Antioxidant Therapy for Cardiovascular Diseases"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2024 | Viewed by 8238
Interests: development of novel molecular probes for DNA sequencing analysis and disease gene discovery; development of new imaging and therapeutic agents towards cancer and cardiovascular disease; design and synthesis of novel prodrugs of peptides and peptide mimetics
Special Issues, Collections and Topics in MDPI journals
Interests: Professor Gibson’s research focus includes understanding the pathophysiology of selected disorders and developing novel pre-clinical treatment approaches with translational relevance.
Cardiovascular oxidative damage occurs when endogenous antioxidant levels are too insufficient to neutralize reactive oxygen species (ROS) and associated free radicals. ROS is associated with the pathophysiology of cardiovascular disorders, including cardiac hypertrophy, cardiomyopathy, heart failure, ventricular remodeling, and myocardial infarction. Due to its high energetic demand, the heart has the highest rate of production of ROS, yet in comparison to other mammalian organs, the heart has a significantly lower level of antioxidants and total antioxidant enzyme activities. It is widely agreed that ROS and oxidative damage are pathological components of cardiovascular diseases (CVDs). Historically, free radicals were merely considered toxins that induce oxidative stress and concomitant cellular damage, and for decades, considerable research has focused on approaches to eliminate excess free radicals generated in the body. Yet, experimental and clinical studies focused on the use of antioxidant therapy to mitigate myocardial damage have yielded mixed results. Moreover, decreasing the systemic level of ROS by using antioxidant therapy may in fact be detrimental in certain instances. Homeostatic mechanisms that maintain the balance between ROS generation and antioxidant production and consumption in CVD require fine tuning for optimal therapeutic outcomes. Our objectives in this Special Issue of Antioxidants are twofold: 1) to re-evaluate the utility and value of antioxidants in the prevention and treatment of CVD; 2) to highlight the expanding efficacy of naturally occurring antioxidants and synthetic antioxidants toward improvement of the functional and structural changes of CVD.
As Guest Editors, we invite you to contribute to the Special Issue on “Antioxidant Therapy for Cardiovascular Diseases”. Original research reports and reviews will be published online in Antioxidants.
Dr. Lanrong Bi
Prof. Dr. K. Michael Gibson
Prof. Dr. Guim Kwon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Oxidative stress
- Free radicals
- Cardiovascular diseases