Oxidation of Lipids and Proteins in Various Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1423

Special Issue Editors


E-Mail Website
Guest Editor
Laboratory of Biochemistry, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: biomarkers; oxidative stress; antioxidants; lipid peroxidation; nutrition
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Interests: functional proteomics; cancer biology; neurodegenerative diseases; system biology; bioinformatics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Oxidative stress, defined as the imbalance between free radicals and antioxidant mechanisms, is considered to play a central role in the pathophysiology of different diseases. Free radicals produced in the human body or received environmentally oxidize both lipids and proteins, causing the production of lipid peroxides and oxidized forms of proteins. Lipid peroxidation alters cell membranes and lipoprotein structure, initiating atherosclerotic plaque formation and increasing the risk for cardiovascular diseases and microvascular dysfunction of different organs. In parallel, protein oxidation, caused either directly by free radicals or indirectly by oxidative stress by-products, is crucial for the modification of their structure and disruption of their function, leading to the development of different pathologies.

This Special Issue aims to provide physicians with useful information about the role of oxidative stress in the pathophysiology of different diseases and about the role of antioxidants in the prevention of the oxidation of lipids and proteins in the frame of each disease. Therefore, manuscripts in the field of neurology, nephrology, hematology, cardiology, endocrinology, pneumology, and other medical specialties are welcome in this Special Issue. Moreover, manuscripts presenting results of basic research in the fields of lipidomics and redox proteomics can offer useful information on the role of oxidative modifications of lipids and proteins in pathological conditions.

We invite you to contribute to this Special Issue by sharing your updated knowledge and your novel research results. 

Dr. Kali Makedou
Dr. Michalis Aivaliotis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • free radicals
  • antioxidants
  • oxidative stress
  • lipid peroxidation
  • protein oxidation
  • lipidomics
  • proteomics
  • diseases
  • neurology
  • nephrology
  • endocrinology
  • hematology
  • pneumology

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 771 KiB  
Article
Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis
by Aleksandra Klisic, Mirjana Bakic and Vesna Karanikolic
Antioxidants 2023, 12(10), 1875; https://doi.org/10.3390/antiox12101875 - 18 Oct 2023
Cited by 5 | Viewed by 1171
Abstract
Aim: There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find [...] Read more.
Aim: There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive and specific oxidative stress biomarker that could best reflect the existence of one of these disease entities. Methods: Forty patients with PsO and forty patients with AD were consecutively included in this cross-sectional study. Parameters of redox homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) and advanced oxidation protein products (AOPP)] and antioxidants [catalase (CAT) and superoxide dismutase (SOD)] were determined. Results: There was no difference in oxidative stress biomarkers between the PsO and AD group, except for higher CAT activity in the AD group (p < 0.001). Among all examined redox homeostasis biomarkers, ROC analysis showed that only CAT exhibited good diagnostic accuracy (AUC = 0.719) in the discrimination of patients with PsO vs. AD, with 0.436 U/L as the cut-off value of CAT activity. Conclusions: The CAT exhibited good diagnostic accuracy in the discrimination of patients with AD from those with PsO. The obtained results could suggest the importance of the use of antioxidants as a potential therapeutic strategy in the treatment of these two skin inflammatory diseases. Full article
(This article belongs to the Special Issue Oxidation of Lipids and Proteins in Various Diseases)
Show Figures

Figure 1

Back to TopTop