Antioxidant Defence System during Arthritis and Osteoarthritis

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 269

Special Issue Editor

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 84104 Bratislava, Slovakia
Interests: oxidative stress; rheumatoid arthritis; enzymatic antioxidant defence system; glutathione peroxidases; superoxide dismutase; catalase; thioredoxin; antioxidant treatment

Special Issue Information

Dear Colleagues,

Oxidative stress is an important factor in chronic autoimmune inflammatory diseases such as rheumatoid arthritis (RA). It is defined as a disequilibrium inflicted by an overproduction of reactive oxygen and nitrogen species, which are associated with the reduced antioxidant capacity of the organism. These radicals often result in metabolic dysfunction and react with macromolecules in their structures, thus altering their functions.

Osteoarthritis (OA) is the most common joint disorder with increasing prevalence due to the aging of the population. Its multi-factorial etiology also includes oxidative stress and the overproduction of reactive oxygen species, which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation along with synovial inflammation and dysfunction of the subchondral bone. Under physiological conditions, the inactivation of these radicals occurs by means of enzymatic and non-enzymatic defence systems and antioxidants. This Special Issue will mainly focus on the endogenous enzymatic antioxidant defence system, including glutathione peroxidases, superoxide dismutase, catalase, and thioredoxin, which have altered functions in patients with RA and OA. In addition, treatments that aim to restore the redox balance in organisms will be included in the scope of this Special Issue.

We invite you to submit your contributions in this research field in the form of a research article or a review article. Since few therapeutic interventions exist to control oxidative stress in RA and OA patients, we hope that your research will help RA and OA patients in the future.

Dr. Silvester Poništ
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • rheumatoid arthritis
  • enzymatic antioxidant defence system
  • glutathione peroxidases
  • superoxide dismutase
  • catalase
  • thioredoxin
  • antioxidant treatment

Published Papers

There is no accepted submissions to this special issue at this moment.
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