Dear Colleagues,

At present, numerous data have been accumulated on the role of the redox in the regulation of immunity. Redox is involved in the modulation of the functions of adaptive and innate immune cells, and also mediates their interaction. Redox sensitive components are found in signaling pathways that regulate the immune response. The activation of the immune response occurs in parallel with the release of reactive oxygen species and reactive nitrogen species, which in turn act as triggers, mediators or modulators of pathways involved in immune regulation.

Immune responses tend to be deregulated during aging. While the efficiency of adaptive immunity declines, innate immunity exhibits a shift toward an excessive response and inflammation. Recently, there has been increasing interest in the hyperactive immune response in the absence of infection, or so-called sterile inflammation—a phenomenon with a potential age-related component. Among the inflammatory triggers are reactive oxygen species, changes in redox, and redox-related damages. Changes in cellular redox and a shift towards a pro-oxidant state are also associated with aging, and disbalanced redox is considered a major contributor to aging and premature senescence.

This Special Issue welcomes original research papers and review articles related to the study of the relationship between immunity and aging and their control by redox-sensitive components. Submissions can be devoted to the following issues:

• Identification of changes in the immune system leading to increase in the chronic pro-inflammatory state;
• Identification of new redox-sensitive components of the immune signaling pathways;
• Identification of factors that lead to chronic inflammation in the aging process;
• Defining the mechanisms that govern the inter-relationship between innate immunity and aging;
• Epigenetic regulation of the immune pathways and identification of the redox-sensitive epigenetic modifications involved in the regulation of aging and age-related immune function;
• Redox regulation of mucosal immunity;
• The role of small molecules/compounds, including low-molecular-weight thiols and biological gases, in modulating the immune response during aging;
• Inflammaging.

Dr. Svetlana N. Radyuk
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• redox
• aging
• immunity
• epigenetics
• inflammation
• inflammaging