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Antioxidants
Special Issues
Redox Homeostasis in Response to Exogenous Stimuli
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Redox Homeostasis in Response to Exogenous Stimuli

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 6540

Special Issue Editor

Dr. Morana Jaganjac

E-Mail Website
Guest Editor
Laboratory for Oxidative Stress (LabOS), Division of Molecular Medicine, Ruder Boskovic Institute, HR-10000 Zagreb, Croatia
Interests: oxidative stress; lipid peroxidation; redox proteomics; metabolic profiling; toxicology; inflammation; metabolic syndrome; carcinogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress has been implicated in the development and progression of chronic diseases, including cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. Exposure to exogenous stimuli such as environmental pollutants, tobacco smoke, alcohol, UV radiation, foods and drugs, ozone, as well as xenobiotics can impair body redox homeostasis and contribute to oxidative stress. Long-term exposure to pro-oxidants has harmful effects on biomolecules and can affect diverse cellular processes and functions. This Special Issue aims to bring together original research and review articles highlighting the impact of exogenous stimuli on redox homeostasis and biological relevance, and on the methodological approaches used to monitor the consequences of exogenous stimuli-induced oxidative stress.

We look forward to your contribution.

Dr. Morana Jaganjac
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive oxygen species
  • lipid peroxidation
  • exogenous stimuli
  • toxicology
  • radiation
  • xenobiotics
  • signal transduction
  • chronic diseases

Published Papers (2 papers)

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Research

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15 pages, 4559 KiB  
Article
Caloric Restriction Mitigates Kidney Fibrosis in an Aged and Obese Rat Model
by Daniele La Russa, Laura Barberio, Alessandro Marrone, Anna Perri and Daniela Pellegrino
Antioxidants 2023, 12(9), 1778; https://doi.org/10.3390/antiox12091778 - 18 Sep 2023
Viewed by 931
Abstract
Caloric restriction is an effective intervention to protract healthspan and lifespan in several animal models from yeast to primates, including humans. Caloric restriction has been found to induce cardiometabolic adaptations associated with improved health and to delay the onset and progression of kidney [...] Read more.
Caloric restriction is an effective intervention to protract healthspan and lifespan in several animal models from yeast to primates, including humans. Caloric restriction has been found to induce cardiometabolic adaptations associated with improved health and to delay the onset and progression of kidney disease in different species, particularly in rodent models. In both aging and obesity, fibrosis is a hallmark of kidney disease, and epithelial–mesenchymal transition is a key process that leads to fibrosis and renal dysfunction during aging. In this study, we used an aged and obese rat model to evaluate the effect of long-term (6 months) caloric restriction (−40%) on renal damage both from a structural and functional point of view. Renal interstitial fibrosis was analyzed by histological techniques, whereas effects on mesenchymal (N-cadherin, Vimentin, Desmin and α-SMA), antioxidant (SOD1, SOD2, Catalase and GSTP1) inflammatory (YM1 and iNOS) markers and apoptotic/cell cycle (BAX, BCL2, pJNK, Caspase 3 and p27) pathways were investigated using Western blot analysis. Our results clearly showed that caloric restriction promotes cell cycle division and reduces apoptotic injury and fibrosis phenotype through inflammation attenuation and leukocyte infiltration. In conclusion, we highlight the beneficial effects of caloric restriction to preserve elderly kidney function. Full article
(This article belongs to the Special Issue Redox Homeostasis in Response to Exogenous Stimuli)
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Review

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26 pages, 3524 KiB  
Review
Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
by Russel J. Reiter, Ramaswamy Sharma, Alejandro Romero, Walter Manucha, Dun-Xian Tan, Debora Aparecida Pires de Campos Zuccari and Luiz Gustavo de Almeida Chuffa
Antioxidants 2023, 12(3), 695; https://doi.org/10.3390/antiox12030695 - 11 Mar 2023
Cited by 6 | Viewed by 5120
Abstract
Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day [...] Read more.
Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels relative to blood concentrations and its likely synthesis in the oocyte, granulosa, and luteal cells suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review the literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary, especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization–embryo transfer (IVF-ET) procedures, and help solve the progressively increasing problem of non-aging-related infertility in women throughout their reproductive life span. While additional research is needed to fully understand the effects of melatonin supplementation on potentially enhancing fertility, studies published to date suggest it may be a promising option for those struggling with infertility. Full article
(This article belongs to the Special Issue Redox Homeostasis in Response to Exogenous Stimuli)
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