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Special Issue "Oxidative Stress-Induced Neurotoxicity and Mitochondrial Dysfunction"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (1 April 2023) | Viewed by 8846
Special Issue Editors
E-Mail Website1 Website2
Interests: molecular mechanism; risk assessment; natural detoxicates; signaling pathways; animal-derived food safety
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Interests: oxidative stress; molecular mechanism; toxicology; risk assessment; neurotoxicity
Special Issue Information
Neurotoxicity can be induced by many drugs and environmental toxins, including antibacterial drugs (e.g., colistin, and cefepime), anticancer drugs (e.g., paclitaxel, bortezomib, and cisplatin), heavy metals (e.g., cadmium, copper, and lead), and pathogenic toxins (e.g., lipopolysaccharide [LPS], T-2 toxin, and deoxynivalenol), finally resulting in the development of irreversible neurodegeneration and even death in humans and animals. Understanding the precise molecular mechanisms involved in neurotoxicity is essential to the development of effective agents and novel therapeutic strategies for its treatment. Cellular oxidative stress is a consequence of an imbalance between the generation and detoxification of reactive oxygen species (ROS). The nervous tissue is highly vulnerable to oxidative damage due to its high energy demand, high oxygen consumption, and abundance of peroxidiable fatty acids. In addition, mitochondria, the ‘power plant’ of cells, are the main producer and target of cellular ROS. Oxidative stress usually causes mitochondrial dysfunction and, which is often implicated during neurotoxicity and neurological diseases, but effective mechanism-based therapies remain elusive.
Therefore, this Special Issue aims to collate innovative original research and review articles that reveal new pathogenic pathways, potential therapeutic strategies, and neuroprotective agents, particularly focusing on oxidative stress, mitochondrial dysfunction, and their crosstalk to clarify and ameliorate drugs- or toxin-induced neurotoxicity.
Dr. Chongshan Dai
Dr. Shusheng Tang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative stress
- mitochondrial dysfunction
- molecular mechanism
- neuroprotective agents