Synthetic Antioxidants with Neuroprotective Effects
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 281
Special Issue Editor
Interests: bioinorganic; biomimetic catalysts; supramolecular; superoxide dismutase; catalase; peroxidase; artificial photosynthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The brain is especially sensitive to damage generated by oxidative stress since it is an organ exposed throughout life to high consumption of oxygen and, on the other hand, neural membranes are rich in oxidizable polyunsaturated fatty acids. Although its antioxidant system is optimized and prepared for the required metabolism, with different enzymes (i.e., superoxide dismutases, catalases, glutathione peroxidases or the thioredoxin antioxidant system) that can regulate the levels of reactive oxygen species, reality shows us how in some cases, the imbalance that leads to oxidative stress is generated. These imbalances increase with age, and various neurodegenerative diseases are their consequence, such as Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, or Huntington’s disease.
The aging of the population and, consequently, the increase in neurodegenerative disorders associated with oxidative stress causes a growing interest in the development of synthetic antioxidants that can be used for the prevention or therapy of this class of diseases.
The aim of this Special Issue of Antioxidants is to collect high-quality original research papers, review papers, or clinical case reports focused on the neuroprotective effects of synthetic antioxidants, including both synthetic catalysts that mimic enzymes and bioinspired molecules with antioxidant activity.
Prof. Dr. Marcelino Maneiro
Guest Editor
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Keywords
- oxidative stress
- neuroprotection
- ageing
- neurocognitive diseases
- neurodegeneration
- catalytic antioxidants
- superoxide dismutase
- catalase
- peroxidase
