Vitamin C and Cancer

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 2158

Special Issue Editors


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Guest Editor
Department of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, Germany
Interests: vitamin C; cancer; bacteriophages; nutrition; oncogenesis; viruses; infectious diseases

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Guest Editor
Department of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, Germany
Interests: vitamin C; cancer; glioblastoma; pancreas carcinoma; membrane transporters; oxidative stress

E-Mail Website
Guest Editor
Department of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, Germany
Interests: vitamin C; cancer; glioblastoma; malignant melanoma; pancreas carcinoma; flavonoids; epigenetics; senescence; organoids

E-Mail Website
Guest Editor
Department of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, Germany
Interests: natural compounds; micronutrients; vitamin C; epigenetics; HDAC inhibitors; immunomodulators; hepatocellular carcinoma; malignant melanoma; glioblastoma; pancreas carcinoma; hop compounds; NK cells; senescence

Special Issue Information

Dear Colleagues,

Vitamin C is a very well-known water-soluble vitamin that acts as an antioxidant in physiological concentrations. Among others, it is also involved in collagen formation, the synthesis of neurotransmitters, and tissue repair. Unlike most animals, it cannot be synthesized by humans and is accordingly an essential micronutrient.

Cancer patients in advanced stages often show very low, sometimes almost scurvy-like, vitamin C plasma levels, and studies are accumulating that indicate the efficacy of parenteral high-dose vitamin C in the context of the therapy of various tumor entities. This Special Issue will now critically review the suitability of vitamin C in both tumor prevention and tumor therapy. Any original papers, review articles, or short communications that help clarify the possible advantages and disadvantages of vitamin C in this context, whether by elucidating the underlying mechanisms or efficacy in vitro, in vivo, or in clinical trials, are welcome.

Dr. Luigi Marongiu
Dr. Olga Renner
Dr. Markus Burkard
Prof. Dr. Sascha Venturelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • ascorbate
  • vitamin C
  • cancer therapy
  • cancer prevention
  • antioxidants
  • prooxidants
  • oxidative stress
  • epigenetic activity

Published Papers (1 paper)

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Research

23 pages, 8375 KiB  
Article
Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage
by Kittipong Sanookpan, Naphat Chantaravisoot, Nuttiya Kalpongnukul, Chatchapon Chuenjit, Onsurang Wattanathamsan, Sara Shoaib, Pithi Chanvorachote and Visarut Buranasudja
Antioxidants 2023, 12(9), 1775; https://doi.org/10.3390/antiox12091775 - 18 Sep 2023
Cited by 1 | Viewed by 1846
Abstract
Non-small cell lung cancer (NSCLC) poses a significant global health burden with unsatisfactory survival rates, despite advancements in diagnostic and therapeutic modalities. Novel therapeutic approaches are urgently required to improve patient outcomes. Pharmacological ascorbate (P-AscH; ascorbate at millimolar concentration in plasma) [...] Read more.
Non-small cell lung cancer (NSCLC) poses a significant global health burden with unsatisfactory survival rates, despite advancements in diagnostic and therapeutic modalities. Novel therapeutic approaches are urgently required to improve patient outcomes. Pharmacological ascorbate (P-AscH; ascorbate at millimolar concentration in plasma) emerged as a potential candidate for cancer therapy for recent decades. In this present study, we explore the anti-cancer effects of P-AscH on NSCLC and elucidate its underlying mechanisms. P-AscH treatment induces formation of cellular oxidative distress; disrupts cellular bioenergetics; and leads to induction of apoptotic cell death and ultimately reduction in clonogenic survival. Remarkably, DNA and DNA damage response machineries are identified as vulnerable targets for P-AscH in NSCLC therapy. Treatments with P-AscH increase the formation of DNA damage and replication stress markers while inducing mislocalization of DNA repair machineries. The cytotoxic and genotoxic effects of P-AscH on NSCLC were reversed by co-treatment with catalase, highlighting the roles of extracellular hydrogen peroxide in anti-cancer activities of P-AscH. The data from this current research advance our understanding of P-AscH in cancer treatment and support its potential clinical use as a therapeutic option for NSCLC therapy. Full article
(This article belongs to the Special Issue Vitamin C and Cancer)
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