Microbial Metabolism of Phenolic Antioxidants

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2122

Special Issue Editor


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Guest Editor
Laboratorio de Biotecnología Bacteriana, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (ICTAN-CSIC), 28040 Madrid, Spain
Interests: microbial physiology; lactic acid bacteria; omics; fermentation; phenolic antioxidants; regulation of gene expression

Special Issue Information

Dear Colleagues,

Natural phenolic antioxidants comprise a wide variety of molecules with high diverse structural complexity. These metabolites have been studied for years mainly because of their antioxidant, radical scavenging, anti-inflammatory or antimutagenic properties which associate them with chronic disease prevention. On account of their signaling, antimicrobial or inhibitory properties, many of these natural molecules contribute to modulating the composition of plant or animal microbiomes, play a key role in plant defense against microbial pathogens, or impose constraints on the fermentability of lignocellulosic feedstocks.

The metabolic conversion of natural phenolic antioxidants by suitable microbes is a key process to overcoming their toxicity and determining their bioavailability, biological activity and functional efficacy. The metabolic decarboxylation or reduction of hydroxycinnamates into less toxic derivatives during fermentation by some Lactobacillus spp., the production of urolithins from ellagitannins by the gut microbiota, the partial degradation of oleuropein by Lactobacillus spp. to render table olives fit for consumption or the fermentation of daidzein by selected Lactococcus spp. to produce the pharmacokinetically improved derivative equol, exemplify how microbial activity can definitely add to the biological activities of natural phenolic antioxidants.

We invite researchers to contribute to this Special Issue with papers addressing any aspect related to the metabolic conversion of phenolic antioxidants by microbial activity, including insights into the microbial molecular responses to these natural compounds. With this Special Issue, we want to provide a worthwhile contribution to the knowledge base in this field.

Dr. Félix López De Felipe
Guest Editor

Manuscript Submission Information

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Keywords

  • antioxidants
  • phenolic compounds
  • metabolism
  • microbial fermentation
  • microbial response
  • antimicrobial
  • signaling
  • detoxification

Published Papers (1 paper)

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Research

21 pages, 3996 KiB  
Article
Fe (III)-Mediated Antioxidant Response of the Acidotolerant Microalga Coccomyxa onubensis
by María Robles, Rafael Torronteras, Carol Ostojic, Cinta Oria, María Cuaresma, Inés Garbayo, Francisco Navarro and Carlos Vílchez
Antioxidants 2023, 12(3), 610; https://doi.org/10.3390/antiox12030610 - 01 Mar 2023
Cited by 3 | Viewed by 1545
Abstract
Coccomyxa onubensis (C. onubensis) is an acidotolerant microalga isolated from Tinto River (Huelva), which contains high levels of metal cations in solution, mainly Fe (II) and (III), and Cu (II). Fe is more bioavailable at low pH, mainly because Fe (II) [...] Read more.
Coccomyxa onubensis (C. onubensis) is an acidotolerant microalga isolated from Tinto River (Huelva), which contains high levels of metal cations in solution, mainly Fe (II) and (III), and Cu (II). Fe is more bioavailable at low pH, mainly because Fe (II) and Fe (III) are far more soluble, especially Fe (III). For this reason, this study aims to evaluate both physiological and biochemical responses of C. onubensis when subjected to Fe (III)-induced stress. Changes in growth, photosynthetic viability and antioxidant responses to the induced oxidative stress were determined. The results obtained suggest that the addition of moderate Fe (III) levels to C. onubensis cultures results in improved growth and photosynthetic viability. Increases in the intracellular levels of the enzyme superoxide dismutase (SOD) and flavonoids, used as antioxidant response biomarkers, a point at Fe (III)-mediated oxidative stress induction. The apparent decrease in the content of other phenolic molecules and polyunsaturated fatty acids might be understood as a sign of antioxidant molecules' involvement in reactive oxygen species (ROS) scavenging. In conclusion, a noticeable antioxidant capacity displayed by C. onubensis allows the use of moderate Fe (III) levels to trigger the accumulation of valuable antioxidant molecules, allowing the production of cell extracts with potential anti-inflammatory activity. Full article
(This article belongs to the Special Issue Microbial Metabolism of Phenolic Antioxidants)
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