Antioxidant and Cytotoxic Effects of Phytochemicals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2704

Special Issue Editors

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: phytochemicals; oxidative stress; cancer; genotoxicity; in vitro toxicology; cancer cell death; nanotoxicology
Special Issues, Collections and Topics in MDPI journals
1. LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal
2. Faculty of Agrarian Sciences and Environment, University of the Azores, 9700-042 Angra Do Heroísmo, Portugal
Interests: phytochemicals; polyphenols; antioxidants; anti-inflammatory agents; in vitro non-cellular and cellular assays
Special Issues, Collections and Topics in MDPI journals
Department of Biology, CESAM—Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: cytotoxicity; genotoxicity; nanoparticles for biological applications; nanotoxicity; drug delivery
Special Issues, Collections and Topics in MDPI journals
Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: in vitro cell culture; cytotoxicity; genotoxicity; cancer therapy; nanobiomedicine; nanotoxicology; human health; environmental toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals are plant metabolites with diverse functions, including protection against biotic and abiotic stress. Oxidative stress and reactive species (RS) accumulation are pathological features that are intrinsically related to the development of cancer-related diseases. The antioxidant properties of phytochemicals have been linked to their ability to scavenge RS and prevent cellular damage caused by oxidative stress. Additionally, many phytochemicals have been shown to exhibit cytotoxic effects against cancer cells, including proapoptotic effects, making them attractive therapeutic agents.

This Special Issue welcomes original research and reviews on the antioxidant and cytotoxic effects of phytochemicals. Articles pertaining to the physicochemical properties, bioactivity, and cell delivery of phytochemicals, and their potential use as therapeutic agents for cancer and other diseases, are welcome. This research covers both in vitro and in vivo studies related to any of the following topics: phytochemicals’ structure–function relationship; reactive species scavenging or the modulation of their production; the role of phytochemicals in antioxidant defense systems and pathways; inflammation; mitochondrial disfunction; DNA damage; cancer cell death; and optimal drug delivery.

We look forward to receiving your contributions.

Dr. José Miguel P. Ferreira de Oliveira
Dr. Daniela Ribeiro
Dr. Helena Oliveira
Dr. Verónica Bastos
Guest Editors

Manuscript Submission Information

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Keywords

  • phenolic compounds
  • Nrf2
  • reactive species
  • phytochemistry
  • plant natural products
  • redox signaling
  • oxidative stress
  • antioxidant systems
  • cellular damage
  • cell death pathways
  • drug delivery

Published Papers (2 papers)

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Research

18 pages, 5524 KiB  
Article
Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth
Antioxidants 2023, 12(9), 1744; https://doi.org/10.3390/antiox12091744 - 10 Sep 2023
Cited by 4 | Viewed by 890
Abstract
Osteosarcoma (OS) is a common childhood sarcoma, and its treatment is hindered by adverse effects, chemoresistance, and recurrence. Interleukin (IL)-6 production by tumors plays a significant role in inflammation, carcinogenesis, and metastasis. This study aimed to investigate the antiproliferative potential of luteolin derivatives [...] Read more.
Osteosarcoma (OS) is a common childhood sarcoma, and its treatment is hindered by adverse effects, chemoresistance, and recurrence. Interleukin (IL)-6 production by tumors plays a significant role in inflammation, carcinogenesis, and metastasis. This study aimed to investigate the antiproliferative potential of luteolin derivatives in OS and to evaluate interleukin production. MG-63, Saos-2, HOS, and 143B human OS cell lines were incubated with luteolin and eight derivatives containing hydroxy, chlorine, or alkyl substitutions. The cell viability and growth were evaluated in the presence of these compounds. Apoptosis was also examined through the analysis of the Bax expression and caspase-3 activity. Finally, the gossypetin effects were measured regarding the production of proinflammatory cytokines interleukin (IL)-6, IL-1β, and IL-12p70. Our findings show that gossypetin was the most potent compound, with proliferation-suppressing activities that induced a series of critical events, including the inhibition of the cell viability and growth. Apoptosis was associated with enhanced caspase-3 activity and increased Bax expression, indicating the involvement of the intrinsic pathway of apoptosis. Moreover, pre-/co-treatment with gossypetin significantly reduced the autocrine production of proinflammatory cytokines. Further investigation is required; nevertheless, considering the link between inflammation, carcinogenesis, and metastasis in OS, our findings suggest that gossypetin exhibits anti-proliferative and anti-inflammatory properties that are potentially relevant in the clinical context. Full article
(This article belongs to the Special Issue Antioxidant and Cytotoxic Effects of Phytochemicals)
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14 pages, 5358 KiB  
Communication
Antioxidant and Cytotoxic Potential of Carlina vulgaris Extract and Bioactivity-Guided Isolation of Cytotoxic Components
Antioxidants 2023, 12(9), 1704; https://doi.org/10.3390/antiox12091704 - 01 Sep 2023
Cited by 1 | Viewed by 1495
Abstract
Carlina vulgaris is a poorly understood plant in the context of biological activity, despite its widespread application in ethnomedicine in numerous European countries. The aim of this study was to assess the cytotoxic potential of the plant against human colorectal adenocarcinoma (HT29) and [...] Read more.
Carlina vulgaris is a poorly understood plant in the context of biological activity, despite its widespread application in ethnomedicine in numerous European countries. The aim of this study was to assess the cytotoxic potential of the plant against human colorectal adenocarcinoma (HT29) and to isolate the plant components linked to this effect. Ultra-high performance liquid chromatography with a high-resolution/quadrupole time-of-flight mass spectrometer (UHPLC–HR/QTOF/MS–PDA) was used for the phytochemical characterization of the extract. Liquid–liquid extraction and preparative chromatography were employed for fractionation purposes. Our investigation demonstrated that the ethyl acetate fraction from C. vulgaris showed significant cytotoxicity, and a bioactivity-guided approach led to the isolation of oxylipins, including traumatic acid, pinellic acid, and 9,10-dihydroxy-8-oxsooctadec-12-enic acid. The structures of the compounds were confirmed by nuclear magnetic resonance spectroscopy. Among these compounds, the last one exhibited significant cytotoxicity, though without selectivity, and traumatic acid was characterized by mild cytotoxicity. The cytotoxicity was linked to intracellular reactive oxygen species generation. Full article
(This article belongs to the Special Issue Antioxidant and Cytotoxic Effects of Phytochemicals)
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