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Antioxidants
Special Issues
Salivary Markers of Oxidative Stress and Oral Diseases
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Salivary Markers of Oxidative Stress and Oral Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 2772

Special Issue Editor

Dr. Peter Celec

E-Mail Website
Guest Editor
Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
Interests: salivary biomarkers; extracellular DNA; deoxyribonuclease; sex differences; salivary testosterone

Special Issue Information

Dear Colleagues,

Oral diseases such as periodontitis or caries are among the most common human diseases. Despite decades of research, the detailed etiopathogenesis is not clear. The interaction between microorganisms, the host tissues, and the immune system seems to be crucial. The production of free radicals is part of the resulting inflammation in gingivitis and periodontitis, but can also lead to mutations that cause oral cancer. Antioxidant intervention could thus be a potential preventive or therapeutic approach, although until now with limited evidence. Identifying pathophysiological mechanisms related to oxidative damage in oral diseases is important for further improvements.

This Special Issue welcomes original articles as well as reviews and meta-analyses focusing on oxidative-stress-related biomarkers, pathomechanisms and interventions in any oral diseases with the use of saliva as a non-invasive diagnostic fluid. Manuscripts describing both preclinical experiments as well as clinical studies with new results regardless of their positivity are of special interest.

Dr. Peter Celec
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • saliva
  • salivary
  • oral health
  • oral diseases
  • oxidative stress biomarkers
  • antioxidant intervention

Published Papers (1 paper)

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Review

19 pages, 2618 KiB  
Review
Dental Caries and Salivary Oxidative Stress: Global Scientific Research Landscape
by Yago Gecy de Sousa Né, Weslley Ferreira Lima, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Renata Duarte de Souza-Rodrigues, Luiz Renato Paranhos, Paulo Antônio Martins-Júnior and Rafael Rodrigues Lima
Antioxidants 2023, 12(2), 330; https://doi.org/10.3390/antiox12020330 - 31 Jan 2023
Cited by 8 | Viewed by 2346
Abstract
This study aimed to analyze the research trends on salivary oxidative stress associated with dental caries and to perform bibliometric approaches for existing publications on this association. A search was performed using the Web of Science Core Collection, without any restriction of language [...] Read more.
This study aimed to analyze the research trends on salivary oxidative stress associated with dental caries and to perform bibliometric approaches for existing publications on this association. A search was performed using the Web of Science Core Collection, without any restriction of language or publication year. The number of periodicals with the most published articles in this theme, most published authors and keywords were mapped; other metrics were also evaluated such as the countries that have more research on the subject and the period in which there were more publications on the subject. During the knowledge mapping, the most frequent experimental designs were analyzed, type of saliva collection, stage of caries disease, evaluated oxidative parameters were retrieved and analyzed from each manuscript. Between the 43 selected articles, the Journal of Clinical Pediatric Dentistry was the periodical appearing the most with 4 published articles. The authors who published the most were Celec, P., Tothova, L., Hegde, A.M., Shetty, S., Antoniali, C., and Pessan, JP with three articles each, and a total of 180 keywords representing the evolution of the theme. India and Asia were found to be the country and continent with most publications, respectively. Most articles collected non-stimulated total saliva, with total antioxidant capacity being the parameter most often evaluated. The type of study that appeared the most was cross-sectional studies, and articles published in the period of 2017–2022 were the most frequent. Studies show that dental caries can be associated to the changes in salivary oxidative biochemistry with an increase in lipid peroxidation, a biomarker of oxidative damage, and an increase in antioxidant capacity in chronic caries, in response to cariogenic challenge. Some studies evidence the reduction of lipid peroxidation after treatment of the carious lesion. Our findings reveal worldwide research trends, as well as a clearer knowledge of the evolution and future scenarios of this issue, also showing the mechanisms associating dental caries with changes in salivary oxidative biochemical parameters are not clear. Full article
(This article belongs to the Special Issue Salivary Markers of Oxidative Stress and Oral Diseases)
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