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Antioxidants
Special Issues
Valorization of the Antioxidant Power of Nature Compounds
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Valorization of the Antioxidant Power of Nature Compounds

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 5187

Special Issue Editors

Dr. Francesca Aiello

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Guest Editor
Department of Pharmacy, Health, and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, CS, Italy
Interests: synthesis of heterocyclic compounds; chemotherapeutics; antioxidants; food-derived bioactive molecules; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Roberta Cassano

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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy
Interests: drug delivery systems (DDS); biomaterials; multifunctional carriers; micro-and nano-particles; pro-drugs
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Luisa Di Gioia

E-Mail Website
Guest Editor
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Arcavacata di Rende, Italy
Interests: organic synthesis; peptide synthesis; green chemistry; natural compounds; sustainable chemical processes; green solvents; deep eutectic solvents
Special Issues, Collections and Topics in MDPI journals
Dr. Sonia Trombino

E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy
Interests: drug delivery systems (DDS); biomaterials; multifunctional carriers; micro- and nano-particles; pro-drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural compounds still maintain their iconic status as a valuable source of drugs, and are endowed with remarkable pharmaceutical properties. Although they show great antioxidant power in vitro, this activity is not exerted in vivo—due to their low bioavailability. In recent years, new strategies have been emerging for improving the antioxidant performance of natural compounds, with the aim of optimizing safe and efficacious therapeutic tools. Many chemical modifications of the base skeleton are constructed to mask functional groups that limit bioavailability, or to introduce moieties able to ameliorate it. In this context, the search for environmentally friendly alternatives, safer procedures and solvents is currently a matter of intense research. The inclusion of biopolymers or natural devices is also useful for promoting a controlled release of the active ingredient and, at the same time, preserving its structural integrity and antioxidant activity. Moreover, the synthesis of biopolymers enables us to entrap natural compounds and formulate new food or pharmaceutical ingredients.

Therefore, this Special Issue aims to collect and publish the recent advances (reviews and research articles) in this interdisciplinary area, comprising the following topics:

  • Green extraction of natural compounds;
  • Vehiculation of natural antioxidants;
  • Chemical modification of secondary metabolites;
  • Drug delivery systems;
  • Medical devices;
  • Functional foods.

Dr. Francesca Aiello
Dr. Roberta Cassano
Dr. Maria Luisa Di Gioia
Dr. Sonia Trombino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • antioxidant activity
  • green extraction
  • green solvents
  • green chemistry
  • nanotechnology
  • natural and synthetic materials

Published Papers (3 papers)

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Research

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15 pages, 1488 KiB  
Article
Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells
by Kitti Szőke, Richárd Kajtár, Alexandra Gyöngyösi, Attila Czompa, Adina Fésüs, Eszter Boglárka Lőrincz, Ferenc Dániel Petróczi, Pál Herczegh, István Bak, Anikó Borbás, Ilona Bereczki and István Lekli
Antioxidants 2023, 12(9), 1714; https://doi.org/10.3390/antiox12091714 - 04 Sep 2023
Cited by 1 | Viewed by 1160
Abstract
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid that can be found in Cannabis sativa and possesses numerous pharmacological effects. Due to these promising effects, CBD can be used in a wide variety of diseases, for instance cardiovascular diseases. However, CBD, like tetrahydrocannabinol (THC), has [...] Read more.
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid that can be found in Cannabis sativa and possesses numerous pharmacological effects. Due to these promising effects, CBD can be used in a wide variety of diseases, for instance cardiovascular diseases. However, CBD, like tetrahydrocannabinol (THC), has low bioavailability, poor water solubility, and a variable pharmacokinetic profile, which hinders its therapeutic use. Chemical derivatization of CBD offers us potential ways to overcome these issues. We prepared three new CBD derivatives substituted on the aromatic ring by Mannich-type reactions, which have not been described so far for the modification of cannabinoids, and studied the protective effect they have on cardiomyocytes exposed to oxidative stress and hypoxia/reoxygenation (H/R) compared to the parent compound. An MTT assay was performed to determine the viability of rat cardiomyocytes treated with test compounds. Trypan blue exclusion and lactate dehydrogenase (LDH) release assays were carried out to study the effect of the new compounds in cells exposed to H2O2 or hypoxia/reoxygenation (H/R). Direct antioxidant activity was evaluated by a total antioxidant capacity (TAC) assay. To study antioxidant protein levels, HO-1, SOD, catalase, and Western blot analysis were carried out. pIC50 (the negative log of the IC50) values were as follows: CBD1: 4.113, CBD2: 3.995, CBD3: 4.190, and CBD: 4.671. The newly synthesized CBD derivatives prevented cell death induced by H/R, especially CBD2. CBD has the largest direct antioxidant activity. The levels of antioxidant proteins were increased differently after pretreatment with synthetic CBD derivatives and CBD. Taken together, our newly synthesized CBD derivatives are able to decrease cytotoxicity during oxidative stress and H/R. The compounds have similar or better effects than CBD on H9c2 cells. Full article
(This article belongs to the Special Issue Valorization of the Antioxidant Power of Nature Compounds)
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15 pages, 926 KiB  
Article
Antioxidant Characterization of Six Tomato Cultivars and Derived Products Destined for Human Consumption
by Anna Rita Bianchi, Ermenegilda Vitale, Valeria Guerretti, Giancarlo Palumbo, Isabella Maria De Clemente, Luca Vitale, Carmen Arena and Anna De Maio
Antioxidants 2023, 12(3), 761; https://doi.org/10.3390/antiox12030761 - 21 Mar 2023
Cited by 5 | Viewed by 2870
Abstract
The consumption of fresh tomatoes and processed tomato products is widespread in the Mediterranean diet. This fruit is a valuable source of antioxidants and plays an important role in preventing oxidative stress. This study aimed to investigate the content of antioxidants and measure [...] Read more.
The consumption of fresh tomatoes and processed tomato products is widespread in the Mediterranean diet. This fruit is a valuable source of antioxidants and plays an important role in preventing oxidative stress. This study aimed to investigate the content of antioxidants and measure the total antioxidant capacity (ABTS and DPPH assays) in the peel, pulp, and seed fractions of six tomato cultivars. Finally, some bioactive compounds and total antioxidant activity were also determined in homemade tomato purees, since such homemade production is commonplace in Southern Italy. The level of antioxidants and total antioxidant capacity in each fraction were also calculated based on their actual fresh weight in the whole tomato. The overall results indicated that the peel and seeds of all analysed tomato cultivars contribute significantly to the antioxidant charge of the fruits. Consequently, consuming tomatoes without peel and seeds results in a substantial loss of compounds beneficial for human health. Our results also showed that phenolic and lycopene content, as well as antioxidant activities in all purees are higher than in fresh tomatoes. Based on this evidence, producing homemade tomato puree is a good practice, and its consumption helps prevent oxidative stress damage. Full article
(This article belongs to the Special Issue Valorization of the Antioxidant Power of Nature Compounds)
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Review

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25 pages, 1912 KiB  
Review
Updating the Status quo on the Eco-Friendly Approach for Antioxidants Recovered from Plant Matrices Using Cloud Point Extraction
by Vanja Travičić, Teodora Cvanić, Olja Šovljanski, Tamara Erceg, Milica Perović, Alena Stupar and Gordana Ćetković
Antioxidants 2024, 13(3), 280; https://doi.org/10.3390/antiox13030280 - 25 Feb 2024
Viewed by 677
Abstract
The concepts of “green chemistry” are gaining importance in the agri-food sector due to the need to minimize pollution from toxic chemicals, improve the safety and sustainability of industrial processes, and provide “clean-labeled products” required by consumers. The application of the cloud point [...] Read more.
The concepts of “green chemistry” are gaining importance in the agri-food sector due to the need to minimize pollution from toxic chemicals, improve the safety and sustainability of industrial processes, and provide “clean-labeled products” required by consumers. The application of the cloud point extraction (CPE) is considered a promising alternative to conventional organic solvents. In the CPE, the separation of compounds from the bulk solution occurs by adding a surfactant (either non-ionic or ionic). When the solution is heated to or above a critical temperature, referred to as the cloud point, two phases are formed—micellar and aqueous. Recently, the horizons of the traditional CPE have been increasingly expanding by improved procedures and integration with other techniques, such as the microwave- and ultrasonic-assisted extraction. This article provides an updated overview of the theory and research articles on the CPE from 2018 to 2023 and critically discusses the issues relevant to the potential applicability of the CPE as a promising and green technique for antioxidants recovered from plant materials. Finally, some future perspectives and research needs for improved CPE are presented. Full article
(This article belongs to the Special Issue Valorization of the Antioxidant Power of Nature Compounds)
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