The Interaction of Redox Potential Modulators with Membrane Transporters
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 2607
Special Issue Editor
Interests: transmembrane transport mechanisms; epithelial transport of organic compounds; plasma membrane transport of nutrients in cancer cells; modulation of membrane transport by xenobiotics; changes in membrane transport in pathological conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Membrane transport systems are essential components of cellular and body homeostasis, as they control the traffic of most biomolecules across membranes. They are fundamental to cellular processes, such as cell nutrition, ionic balance and metabolism, and at the organism level, they control nutrition, excretion, drug therapeutic effects and the toxicity of xenobiotics. Mutations in transport protein genes have been identified in the pathogenesis of a number of hereditary diseases, including cystic fibrosis, glucose/galactose malabsorption and Wilson's disease. Moreover, several human conditions are associated with functional changes in specific transporters. For instance, in cancer cells, changes in membrane transporters for important nutrients have been described.
The cellular redox potential interferes with membrane transport systems, but our knowledge about this is still very limited. In this context, several dietary compounds with antioxidant properties, such as polyphenolic compounds, present as interesting modulators of membrane transport activity with a potential beneficial effect on humans’ health.
In this Special Issue, the interaction between compounds able to interfere with the cellular or mitochondrial redox potentials and membrane transporters will be explored.
Potential topics include, but are not limited to, the following:
- The effect of antioxidants or pro-oxidants on membrane transporters;
- The mechanisms involved in the regulation of membrane transporters by the redox potential;
- The effect of dietary compounds with antioxidant or pro-oxidant properties on membrane transport in cancer cells.
Prof. Dr. Fátima Martel
Guest Editor
Manuscript Submission Information
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Keywords
- dietary compounds
- membrane transport
- pathologies
- modulation
