Special Issue "Cellular and DNA Damage in Oxidative Stress Conditions: Cytoprotective and Genoprotective Potential of Antioxidant Molecules"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 8883
Interests: environmental pollutants; nanomaterials; genetic ecotoxicology; sperm DNA damage; anti-genotoxicity; cell death (apoptosis)
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Interests: reproductive toxicology; genotoxicity; antigenotoxicity; cytogenetics; cellular and molecular biology; male and female infertility
Oxidative stress (OS) is a condition that occurs following a redox imbalance in favor of oxidizing molecules. The reasons for the increased production of free radicals in the body are linked to exogenous and/or endogenous factors, such as exposure to toxic substances, incorrect diet, metabolic pathologies, and genetics. In recent years, the involvement of oxidative stress (OS) in the pathogenesis of several human diseases has received growing attention. The phenomena of membrane lipid peroxidation, DNA damage and the induction of apoptosis can arise in cells following exposure to genotoxic substances, exerting detrimental influences on organisms such as early cell aging; atherosclerosis; obesity; diabetes; reproductive disorders, sometimes with transgenerational effects; and even cancer. In this context, antioxidants, by hindering and preventing oxidative damage, given their ability to interrupt radical chain reactions, are considered antigenotoxic agents, as they intervene in cellular protection mechanisms, ultimately preventing the oxidative deterioration of genetic material. This Special Issue focuses on the cytoprotective and genoprotective roles of different antioxidant molecules in preventing disorders related to OS. Researchers are invited to contribute with original manuscripts, reviews and case reports on humans and animals, aiming to elucidate the mechanisms through which OS contribute to the development of several diseases and clarify the role of supplementation with antioxidant substances as a treatment. The topics of particular interest include the in vivo and in vitro effects of antioxidant exposure, the protective activity of different antioxidants in counteracting cell damage related to oxidative stress, antigenotoxic molecules for preventing DNA damage, the DNA-damage response following antioxidant treatment, and the development of new therapies for the treatment of disorders related to oxidative stress.
Topics of particular interest include:
- in vivo and in vitro effect of antioxidant exposure;
- protective activity of different antioxidants in counteract oxidative stress cell damage;
- antigenotoxic molecules for DNA damage prevention;
- DNA-damage response following antioxidant treatment;
- development of new therapies in the treatment of oxidative stress related disorders.
Prof. Dr. Lucia Rocco
Dr. Filomena Mottola
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative stress
- antioxidant molecules
- cancer cell aging
- reproductive diseases
- oxidative damage
- human diseases
- antioxidant therapies