Submit to Special Issue Submit Abstract to Special Issue Review for Antioxidants Propose a Special Issue

Journal Menu

Journal Browser

Special Issue "Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period"

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 April 2024 | Viewed by 4885

Share This Special Issue

Special Issue Editors

Prof. Dr. Endre Sulyok

E-Mail Website1 Website2
Guest Editor

National Laboratory for Human Reproduction, University of Pécs, 7624 Pecs, Hungary
Interests: perinatal adaptation; human reproduction; in vitro fertilization; reproductive endocrinology; reproductive aging; biomarkers; endothelial dysfunction

Prof. Dr. József Bódis

E-Mail Website
Guest Editor

National Laboratory on Human Reproduction and Department of Obstetrics and Gynecology, University of Pecs, Pecs, Hungary
Interests: reproductive endocrinology; gynecology; human reproduction; maternal health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are generated as normal products of cellular metabolism and they have a regulatory role in several basic processes. When their excessive generation exceeds the capacity of antioxidant defense mechanisms, oxidative stress (OS) ensues and ROS react with essential cellular elements (lipids, proteins, and DNA) causing cellular dysfunction, damage, and apoptosis.

During the perinatal period, the antioxidant defense is markedly reduced and the fetus and neonates are at particular risk of adverse effects of ROS. In this Special Issue, comprehensive reviews present evidence for the association of compromised feto-placental circulation, OS, and adverse pregnancy outcomes and for that of the intrauterine growth restriction/prematurity and involvement of OS in prenatally programmed adult diseases. Data are given on the impact of OS on the genome-wide DNA methylation pattern and on the microbiome profile in pregnant women. The OS-related neonatal pathologies and the redox status of human breast milk are also reviewed.

This Special Issue addresses only certain selected topics of perinatal importance of OS; therefore, research groups are invited to contribute by presenting other aspects of this Special Issue. Studies on the exposure to drug administration; the implementation of new, sensitive, early biomarkers of ROS-induced tissue injury; and organ-specific innovative preventive/therapeutic approaches may be of theoretical and clinical significance.

Prof. Dr. Endre Sulyok
Prof. Dr. József Bódis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
ROS
perinatal period
pregnant women
newborns
fetus
maternal and child health
pregnancy complications
human reproduction

Published Papers (4 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle

Blood Plasma Calorimetric Profiles of Women with Preeclampsia: Effect of Oxidative Stress

and

Antioxidants 2023, 12(5), 1032; https://doi.org/10.3390/antiox12051032 - 29 Apr 2023

Viewed by 806

Abstract

Preeclampsia is a pregnancy-related disease with poor placentation and presents itself through hypertension and proteinuria. The disease is also associated with the oxidative modification of proteins in maternal blood plasma. In this work, we combine differential scanning calorimetry (DSC), capillary electrophoresis, and atomic force microscopy (AFM) to evaluate the changes in the plasma denaturation profiles of patients with preeclampsia (PE) as compared with those of pregnant controls. Our results demonstrate that the last trimester of pregnancy substantially affects the main calorimetric characteristics of blood plasma from pregnant controls relative to nonpregnant women. These variations correlate well with the changes in protein levels determined by electrophoresis. DSC analysis revealed significant deviations in the plasma heat capacity profiles of preeclamptic patients from those of pregnant controls. These alterations are expressed mainly in a substantial reduction in albumin-assigned transitions and an upward shift in its denaturation temperature, lower calorimetric enthalpy changes, and a reduced ratio of heat capacity in the albumin/globulin-assigned thermal transitions, which are more pronounced in severe PE cases. The in vitro oxidation model shows that the alteration of PE thermograms is partly related to protein oxidation. AFM data detected numerous aggregate formations in the plasma of PE samples and fewer small ones in the pregnant controls, which are not found in healthy nonpregnant samples. These findings could serve as a basis for further investigations to reveal the possible relationship between albumin thermal stabilization, the increased inflammatory state and oxidative stress, and protein misfolding in preeclampsia. Full article

(This article belongs to the Special Issue Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period)

► Show Figures

Figure 1

Review

Jump to: Research

Open AccessReview

Pathomechanisms of Prenatally Programmed Adult Diseases

Endre Sulyok

Balint Farkas

and

Jozsef Bodis

Antioxidants 2023, 12(7), 1354; https://doi.org/10.3390/antiox12071354 - 28 Jun 2023

Viewed by 545

Abstract

Based on epidemiological observations Barker et al. put forward the hypothesis/concept that an adverse intrauterine environment (involving an insufficient nutrient supply, chronic hypoxia, stress, and toxic substances) is an important risk factor for the development of chronic diseases later in life. The fetus responds to the unfavorable environment with adaptive reactions, which ensure survival in the short run, but at the expense of initiating pathological processes leading to adult diseases. In this review, the major mechanisms (including telomere dysfunction, epigenetic modifications, and cardiovascular–renal–endocrine–metabolic reactions) will be outlined, with a particular emphasis on the role of oxidative stress in the fetal origin of adult diseases. Full article

(This article belongs to the Special Issue Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period)

► Show Figures

Figure 1

Open AccessReview

Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies

and

Antioxidants 2023, 12(6), 1149; https://doi.org/10.3390/antiox12061149 - 24 May 2023

Viewed by 973

Abstract

Less invasive surfactant administration techniques, together with nasal continuous airway pressure (LISA-nCPAP) ventilation, an emerging noninvasive ventilation (NIV) technique in neonatology, are gaining more significance, even in extremely premature newborns (ELBW), under 27 weeks of gestational age. In this review, studies on LISA-nCPAP are compiled with an emphasis on short- and long-term morbidities associated with prematurity. Several perinatal preventative and therapeutic investigations are also discussed in order to start integrated therapies as numerous organ-saving techniques in addition to lung-protective ventilations. Two thirds of immature newborns can start their lives on NIV, and one third of them never need mechanical ventilation. With adjuvant intervention, these ratios are expected to be increased, resulting in better outcomes. Optimized cardiopulmonary transition, especially physiologic cord clamping, could have an additively beneficial effect on patient outcomes gained from NIV. Organ development and angiogenesis are strictly linked not only in the immature lung and retina, but also possibly in the kidney, and optimized interventions using angiogenic growth factors could lead to better morbidity-free survival. Corticosteroids, caffeine, insulin, thyroid hormones, antioxidants, N-acetylcysteine, and, moreover, the immunomodulatory components of mother’s milk are also discussed as adjuvant treatments, since immature newborns deserve more complex neonatal interventions. Full article

(This article belongs to the Special Issue Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period)

► Show Figures

Figure 1

Open AccessReview

The Role of Hydrogen-Peroxide (H₂O₂) Produced by Vaginal Microbiota in Female Reproductive Health

Eva Miko

and

Aliz Barakonyi

Antioxidants 2023, 12(5), 1055; https://doi.org/10.3390/antiox12051055 - 06 May 2023

Cited by 2 | Viewed by 2044

Abstract

Female reproductive health is strongly associated with healthy vaginal microbiota, which is thought to be ensured by the dominance of certain Lactobacillus species. Lactobacilli control the vaginal microenvironment through several factors and mechanisms. One of them is their ability to produce hydrogen peroxide (H₂O₂). The role of Lactobacillus-derived H₂O₂ in the vaginal microbial community has been intensively investigated in several studies with many designs. However, results and data are controversial and challenging to interpret in vivo. Defining the underlying mechanisms responsible for a physiological vaginal ecosystem is crucial since it could directly affect probiotic treatment attempts. This review aims to summarize current knowledge on the topic, focusing on probiotic treatment possibilities. Full article

(This article belongs to the Special Issue Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Oxidative Stress Markers and Endothelial Dysfunction in Pre- and Perinatal Period"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (4 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI