Special Issue "Ascorbic Acid: An Antioxidant and Much More"

Dear Colleagues,

As a molecule, ascorbic acid is a remarkable antioxidant that scavenges free radicals and reactive oxygen species. As a co-substrate for a number of enzymes, ascorbic acid is also instrumental in signaling, gene expression, and cellular metabolism. It is required by enzymes synthesizing norephinephrine and peptide hormones, and it regulates the transcription factor subunit HIF1α (hypoxia-inducible factor 1α) and the TET (Ten-eleven-translocation) DNA demethylases. Of course, the collagen-synthesizing enzymes, prolyl and lysyl hydroxylase, need ascorbic acid to maintain activity; this deficiency causes scurvy, the condition from which ascorbic acid gets its name. Ascorbic acid has been the subject of controversial claims about its effectiveness in combatting diseases such as the common cold and cancer and about the value of consuming megadoses of the vitamin for optimum health. To address these controversies and to truly understand the role of ascorbic acid in human health, we need to take a broader view of its actions. It is my hope that this Special Issue will bring together articles connecting the chemistry of ascorbic acid with its subtle but wide-ranging biological effects. Your work is an important part of this discussion, and I hope you will be willing to contribute your perspective. We invite you to submit your latest research findings or a review article to this Special Issue on “Ascorbic Acid: An Antioxidant and Much More”.

Best regards,

Prof. Dr. David Njus
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• ascorbic acid
• reactive oxygen species
• vitamin C
• epigenetic regulation
• sympathetic signaling