Oxidative Stress in Proteomics and Metabolomics Studies of Cardiovascular Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1424

Special Issue Editors


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Guest Editor
Department of Immunology, IIS-Fundacion Jimenez Diaz, UAM, Avenida Reyes Católicos 2, 28040, Madrid, Spain
Interests: proteomics; metabolomics; mass spectromerty imaging; cardiovascular disease; cardiovascular risk; atherosclerosis; thoracic aortic aneurysm; hypertension; acute kidney injury
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Immunology, IIS-Fundacion Jimenez Diaz, UAM, RICORS2040, Avenida Reyes Católicos 2, 28040 Madrid, Spain
Interests: cardiovascular risk; atherosclerosis; thoracic aortic aneurysm; hypertension; chronic kidney disease; albuminuria; extracellular vesicles; proteomics; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases remain the leading cause of premature death worldwide. Pathophysiological mechanisms operating in cardiac and vascular dysfunction involve a plethora of interconnected molecules within different cells, arterial layers, and subcellular compartments, resulting in biological alterations which ultimately may be visualized in biological fluids. Omics techniques allow accessing this complex framework with an unparalleled overall perspective. Oxidative stress is one of the hallmarks of cardiovascular disease development. However, despite efforts, antioxidant treatments have not been successful in controlling the development of cardiovascular diseases. Further investigation is needed in both senses, improving the knowledge of the underlying mechanisms and also identifying and monitoring therapeutic targets and effective antioxidants drugs.

The aim of this Special Issue is to compile novel studies involving oxidative stress in cardiovascular diseases via omics approaches (proteomics, metabolomics, lipidomics). Manuscripts investigating other diseases directly associated with increased cardiovascular risk, e.g., hypertension, diabetes mellitus, or chronic kidney disease, are also welcome. Because of the large amount of data generated through unbiased omics approaches, systems biology analyses are mandatory for a better understanding of cardiovascular diseases and are thus also considered in this Special Issue.

Dr. Marta Martin-Lorenzo
Dr. Gloria Alvarez-Llamas
Guest Editors

Manuscript Submission Information

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Keywords

  • oxidative stress
  • proteomics
  • metabolomics
  • lipidomics
  • cardiovascular disease
  • atherosclerosis
  • aneurysm
  • heart failure
  • vascular remodeling
  • mitochondria
  • systems biology

Published Papers (1 paper)

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Research

24 pages, 6122 KiB  
Article
Oxidative Post-translational Protein Modifications upon Ischemia/Reperfusion Injury
by Aleksandra Binek, Celia Castans, Inmaculada Jorge, Navratan Bagwan, José Manuel Rodríguez, Rodrigo Fernández-Jiménez, Carlos Galán-Arriola, Eduardo Oliver, Mónica Gómez, Agustín Clemente-Moragón, Borja Ibanez, Emilio Camafeita and Jesús Vázquez
Antioxidants 2024, 13(1), 106; https://doi.org/10.3390/antiox13010106 - 16 Jan 2024
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Abstract
While reperfusion, or restoration of coronary blood flow in acute myocardial infarction, is a requisite for myocardial salvage, it can paradoxically induce a specific damage known as ischemia/reperfusion (I/R) injury. Our understanding of the precise pathophysiological molecular alterations leading to I/R remains limited. [...] Read more.
While reperfusion, or restoration of coronary blood flow in acute myocardial infarction, is a requisite for myocardial salvage, it can paradoxically induce a specific damage known as ischemia/reperfusion (I/R) injury. Our understanding of the precise pathophysiological molecular alterations leading to I/R remains limited. In this study, we conducted a comprehensive and unbiased time-course analysis of post-translational modifications (PTMs) in the post-reperfused myocardium of two different animal models (pig and mouse) and evaluated the effect of two different cardioprotective therapies (ischemic preconditioning and neutrophil depletion). In pigs, a first wave of irreversible oxidative damage was observed at the earliest reperfusion time (20 min), impacting proteins essential for cardiac contraction. A second wave, characterized by irreversible oxidation on different residues and reversible Cys oxidation, occurred at late stages (6–12 h), affecting mitochondrial, sarcomere, and inflammation-related proteins. Ischemic preconditioning mitigated the I/R damage caused by the late oxidative wave. In the mouse model, the two-phase pattern of oxidative damage was replicated, and neutrophil depletion mitigated the late wave of I/R-related damage by preventing both Cys reversible oxidation and irreversible oxidation. Altogether, these data identify protein PTMs occurring late after reperfusion as an actionable therapeutic target to reduce the impact of I/R injury. Full article
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