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Antioxidants
Special Issues
Oxidative and Nitrosative Stress-Related Mechanisms and Antioxidant Therapy in Respiratory...
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Oxidative and Nitrosative Stress-Related Mechanisms and Antioxidant Therapy in Respiratory Disorders

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 1136

Special Issue Editor

Dr. Paolo Cameli

E-Mail Website
Guest Editor
Respiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy
Interests: interstitial lung disease; KL-6; severe asthma; biomarkers; lung transplant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress is widely recognized as one of the major pathogenetic drivers of lung injury and accelerated aging of respiratory epithelium; the aberrant production of reactive oxygen or nitrogen species is a key factor in the pathogenesis of chronic respiratory disorders, including chronic obstructive pulmonary disease, interstitial lung disease and severe asthma. Furthermore, a disequilibrium in the oxidant/antioxidant balance has been described also in lung cancer and appears to be involved in both the pathobiology and progression of disease.

A better and more comprehensive knowledge of the impact of oxidative and nitrosative stress on lung disorders could help to identify novel severity and prognostic biomarkers and to implement new therapeutic targets.

As Guest Editors, we invite you to contribute to this Special Issue, whose main focus will be to describe the role of oxidative stress in respiratory disease progression and during therapeutic interventions.

Dr. Paolo Cameli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • chronic respiratory disorders
  • biomarkers

Published Papers (1 paper)

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Research

16 pages, 3267 KiB  
Article
T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model
by Noriki Takahashi, Ryunosuke Nakashima, Aoi Nasu, Megumi Hayashi, Haruka Fujikawa, Taisei Kawakami, Yuka Eto, Tomoki Kishimoto, Ayami Fukuyama, Choyo Ogasawara, Keisuke Kawano, Yukio Fujiwara, Mary Ann Suico, Hirofumi Kai and Tsuyoshi Shuto
Antioxidants 2024, 13(1), 30; https://doi.org/10.3390/antiox13010030 - 22 Dec 2023
Viewed by 919
Abstract
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary condition characterized by bronchitis, emphysema, and mucus stasis. Due to the variability in symptoms among patients, traditional approaches to treating COPD as a singular disease are limited. This led us to focus on phenotype/endotype [...] Read more.
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary condition characterized by bronchitis, emphysema, and mucus stasis. Due to the variability in symptoms among patients, traditional approaches to treating COPD as a singular disease are limited. This led us to focus on phenotype/endotype classifications. In this study, we explore the potential therapeutic role of thyroid hormone (T3) by using mouse models: emphysema-dominant elastase-induced COPD and airway-dominant C57BL/6-βENaC-Tg to represent different types of the disease. Here, we showed that intratracheal T3 treatment (40, 80 μg/kg, i.t., every other day) resulted in significant improvements regarding emphysema and the enhancement of respiratory function in the elastase-induced COPD model. T3-dependent improvement is likely linked to the up-regulation of Ppargc1a, a master regulator of mitochondrial biogenesis, and Gclm, a factor associated with oxidative stress. Conversely, neither short- nor long-term T3 treatments improved COPD pathology in the C57BL/6-βENaC-Tg mice. Because the up-regulation of extrathyroidal T3-producing enzyme Dio2, which is also considered a marker of T3 requirement, was specifically observed in elastase-induced COPD lungs, these results demonstrate that exogenous T3 supplementation may have therapeutic potential for acute but not chronic COPD exacerbation. Moreover, this study highlights the relevance of considering not only COPD phenotypes but also COPD endotypes (expression levels of Ppargc1a and/or Dio2) in the research and development of better treatment approaches for COPD. Full article
(This article belongs to the Special Issue Oxidative and Nitrosative Stress-Related Mechanisms and Antioxidant Therapy in Respiratory Disorders)
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