Dear Colleagues,

Oxidative stress occurs when the production of reactive oxygen species/reactive nitrogen species (ROS/RNS) overwhelms the endogenous antioxidant defenses. Under physiological conditions, the amounts of ROS/RNS are finely controlled and “Redox Homeostasis” involves molecular pathways that constantly provide cell equilibrium between their production and clearance/inactivation. During recent decades, overwhelming research evidence shows the central role of oxidative stress in a number of physio-pathological events, including the telomere-independent cell senescence process. In early life, cell senescence represents a safety program to permanently arrest damaged cells, but it is a ruling contributor in aging and age-related diseases. For this reason, particular attention is given to strategies that can delay or counteract senescence induced by ROS/RNS deregulation, thus, improving healthy aging and mitigating age-related diseases.

The senescence process is sustained by a reprogrammed gene expression, involving transcriptional and post-transcriptional mechanisms, as well as epigenetic regulatory events. This Special Issue aims to describe the interplay between oxidative stress, non-coding RNAs (microRNAs, long-non-coding RNAs and circular RNAs) and the senescence process. In recent years, non-coding RNAs turned out to be important redox-sensitive players, acting as regulators in whole signaling networks that can either boost or delay cell senescence. Since their expression or activities can be affected by ROS/RNS levels, non-coding RNAs represent interesting molecules, and ongoing research in the oxidative stress field is focused on this topic. We invite the submission of research findings/reviews delineating activities of these molecules on redox-sensitive signaling linked to senescence. This will contribute toward the emerging evidence concerning the use of synthetic molecules for in vivo delivery or antioxidants supplementation with future therapeutic purposes.

Dr. Raffaella Faraonio
Guest Editor

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• oxidative stress
• cellular senescence
• non-coding RNAs
• redox transcription factors
• antioxidant