The Role of Mitochondrial Redox Regulations in Inflammation and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 237
Special Issue Editor
Interests: mitochondria; energy metabolism; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; misfolded proteins; calcium homeostasis; calcium signaling; oxidative stress; ferroptosis; ROS signaling; epilepsy; ischemia; hypoxia; cancer; brain inorganic polyphosphate
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Redox-dependent processes regulate most of the cellular functions, such as proliferation, differentiation, and apoptosis. Mitochondria are cellular organelles with a pivotal role in many cellular processes, including the production and distribution of energy for all cellular functions, controlling the processes of quality control, protein transport, and biogenesis and programmed cell death, and the regulation of metabolic pathways, ionic homeostasis, thermogenesis, stress responses, cellular signaling, and inflammatory response. Mitochondria, on the one hand, generate reactive oxygen species (ROS) that drive redox-sensitive events and, on the other hand, respond to ROS-mediated changes in the cellular redox state. Therefore, any disruption of mitochondrial function is central to the development of a wide range of major human diseases.
This Special Issue is devoted to providing the latest insights into the role of mitochondrial redox regulation in the molecular mechanisms of mitochondrial redox signalling, the impact of mitochondrial dysfunction on cellular metabolism and inflammation, the role of mitochondrial redox regulation in the pathogenesis of various diseases such as cancer, cardiovascular disease and neurodegenerative disorders and the potential therapeutic implications of targeting mitochondrial redox signalling for the treatment of these diseases.
Dr. Plamena R. Angelova
Guest Editor
Manuscript Submission Information
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Keywords
- redox signalling
- mitochondrial dysfunction
- mitochondrial bioenergetics
- mitochondrial dynamics
- mitochondrial biogenesis
- oxidative stress
- inflammation
- cancer
- diabetes
- neurodegeneration
- cardiovascular diseases
- ischemia-reperfusion injury
