Mitochondrial Oxidative and Nitrosative Stress as a Therapeutic Target in Diseases III
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1439
Special Issue Editors
Interests: liver diseases; nafld; liver fibrosis; nkt cells; liver immunology
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer’s disease; cholesterol in neurodegeneration; mitochondria; mitochondrial oxidative stress; autophagy/mitophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although necessary for life, mitochondria are often essential for initiating apoptotic death and deciding cell fate under cellular stress. Recently, in addition to their role in cell death, mitochondria have been suggested to serve as signaling platforms critical for regulating autophagy and the inflammatory response. Mitochondrial oxidative/nitrosative stress has been reported to trigger autophagy by promoting autophagosome formation and induce the release of inflammatory cytokines through the activation of the NLRP3-inflammasome. Thus, it is becoming clear that mitochondria participate in many aspects of cell function, and evidence further suggests that mitochondria impairment is underlying many common human disorders. Consequently, new strategies are being sought to restore the mitochondrial function therapeutically.
Contributions to this Special Issue may cover research findings or review articles related to the role of mitochondrial oxidative stress and mitochondrial dysfunction in different pathological conditions ranging from cancer to neurodegenerative diseases, the mechanistic links between changes in mitochondria functionality and alterations of cellular processes such as autophagy and the inflammatory signaling pathways and its impact on cell viability, and the use of mitochondria-targeted molecules, including antioxidants, as therapeutic strategies for disease intervention.
Dr. Montserrat Marí
Dr. Anna Colell
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial oxidative stress
- autophagy
- mitophagy
- inflammasome
- antioxidants
- mitochondrial dysfunction
- mitochondrial-targeted molecules
- disease
