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Antioxidants
Special Issues
Antioxidants for Skin Health
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Antioxidants for Skin Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 7280

Special Issue Editor

Dr. Rubia Casagrande

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Health Sciences Center, State University of Londrina, Londrina, Brazil
Interests: the development of novel pharmacological approaches; pharmaceutical forms to treat skin inflammation and oxidative stress

Special Issue Information

Dear Colleagues,

The skin protects our bodies from external challenges. There is a complex interaction between tissue parenchymal cells, tissue-resident immune cells, inervating neurons and migrated immune cells. This cellular interaction involves the communication among these cellular types through soluble mediators, including cytokines, lipids and reactive oxygen and nitrogen species (ROS and RNS). ROS and RNS have a signaling role in cellular communication and function. In addition, ROS and RNS can also cause skin damage. To counteract ROS and RNS, the skin has endogenous antioxidants. The balance between pro-inflammatory/pro-oxidant and anti-inflammatory/antioxidant molecules determines the fate of the skin tissue upon varied challenges. To shape this highly active tissue millieu, we can use varied classes of molecules through systemic and topical administration. This Special Issue covers all aspects pertaining to antioxidants in skin health, including molecules that have antioxidant structural components as well as those molecules that shape oxidative stress without directly having chemical antioxidant groups, and the development of controlled drug release systems.

Dr. Rubia Casagrande
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin inflammation
  • cytokine
  • skin oxidative stress
  • Nrf2
  • reduced glutathione
  • ultraviolet irradiation
  • drug delivery
  • flavonoid
  • terpenes
  • specialized pro-resolution lipid mediators

Published Papers (4 papers)

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Research

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12 pages, 3147 KiB  
Article
Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway
by So Jin Cha, Seon Sook Kim, Jin Hak Shin and Su Ryeon Seo
Antioxidants 2024, 13(1), 131; https://doi.org/10.3390/antiox13010131 - 22 Jan 2024
Viewed by 1066
Abstract
Peiminine is the main natural alkaloid compound extracted from the Chinese herb Fritillaria. Although peiminine is known for its antioxidant and anti-inflammatory effects in conditions such as mastitis and arthritis, its impact on inflammation induced by Cutibacterisum acnes (C. acnes) has [...] Read more.
Peiminine is the main natural alkaloid compound extracted from the Chinese herb Fritillaria. Although peiminine is known for its antioxidant and anti-inflammatory effects in conditions such as mastitis and arthritis, its impact on inflammation induced by Cutibacterisum acnes (C. acnes) has not been explored. The aim of this study was to investigate the effect of peiminine on C. acnes-induced inflammatory responses in the skin and to identify the underlying mechanism involved. We discovered that peiminine inhibits the C. acnes-induced expression of inflammatory mediators such as pro-interleukin-1β (pro-IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in mouse bone marrow-derived macrophages (BMDMs). Peiminine suppressed the activation of nuclear factor-kappa B (NF-κB) without affecting the activation of mitogen-activated protein kinase (MAPK) pathways such as JNK, ERK, and p38 MAPK. In addition, we found that peiminine suppressed inflammatory cytokine expression and ameliorated histological symptoms in C. acnes-induced mouse skin. Our study is the first to provide evidence that peiminine has an inhibitory effect on acne, and it points toward the potential of incorporating peiminine into cosmetic and pharmaceutical formulations for acne treatment. Full article
(This article belongs to the Special Issue Antioxidants for Skin Health)
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18 pages, 7254 KiB  
Article
Geranylgeranylacetone Ameliorates Skin Inflammation by Regulating and Inducing Thioredoxin via the Thioredoxin Redox System
by Tiancheng Jin, Yitong You, Wenjie Fan, Junyang Wang, Yuhao Chen, Shujing Li, Siyuan Hong, Yaxuan Wang, Ruijie Cao, Junji Yodoi and Hai Tian
Antioxidants 2023, 12(9), 1701; https://doi.org/10.3390/antiox12091701 - 31 Aug 2023
Cited by 1 | Viewed by 1173
Abstract
Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism on inducing the TRX of GGA is still unknown. We investigated the effects of GGA in a murine irritant [...] Read more.
Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism on inducing the TRX of GGA is still unknown. We investigated the effects of GGA in a murine irritant contact dermatitis (ICD) model induced by croton oil. Both a topical application and oral administration of GGA induced TRX production and Nrf2 activation. GGA ameliorated ear swelling, neutrophil infiltration, and inhibited the expression of TNF-α, IL-1β, GM-CSF, and 8-OHdG. GGA’s cytoprotective effect was stronger orally than topically in mice. In vitro studies also showed that GGA suppressed the expression of NLRP3, TNF-α, IL-1β, and GM-CSF and scavenged ROS in PAM212 cells after phorbol myristate acetate stimulation. Moreover, GGA induced endogenous TRX production and Nrf2 nuclear translocation in PAM212 cells (dependent on the presence of ROS) and activated the PI3K-Akt signaling pathway. GGA significantly downregulated thioredoxin-interacting protein (TXNIP) levels in PAM212 cells treated with or without Nrf2 siRNA. After knocking down Nrf2 in PAM212 cells, the effect of GGA on TRX induction was significantly inhibited. This suggests that GGA suppress ICD by inducing endogenous TRX, which may be regulated by PI3K/Akt/Nrf2 mediation of the TRX redox system. Full article
(This article belongs to the Special Issue Antioxidants for Skin Health)
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17 pages, 2128 KiB  
Article
Sargassum filipendula, a Source of Bioactive Compounds with Antioxidant and Matrix Metalloproteinases Inhibition Activities In Vitro with Potential Dermocosmetic Application
by Yonadys Luna-Pérez, Lady Giselle Ríos-López, Elver Luis Otero-Tejada, Juan Camilo Mejía-Giraldo and Miguel Ángel Puertas-Mejía
Antioxidants 2023, 12(4), 876; https://doi.org/10.3390/antiox12040876 - 04 Apr 2023
Cited by 3 | Viewed by 2021
Abstract
The antioxidant and the potential inhibitory capacity of matrix metalloproteinases of the phlorotannin-type polyphenolic and fucoidan-type polysaccharides extracts obtained from the macroalga S. filipendula were evaluated. Through chromatographic and spectroscopic techniques, the corresponding chemical structure of compounds present in the extracts was determined. [...] Read more.
The antioxidant and the potential inhibitory capacity of matrix metalloproteinases of the phlorotannin-type polyphenolic and fucoidan-type polysaccharides extracts obtained from the macroalga S. filipendula were evaluated. Through chromatographic and spectroscopic techniques, the corresponding chemical structure of compounds present in the extracts was determined. Antioxidant capacity was evaluated using the methyl linoleate model for the inhibition of lipid peroxidation, and the free radical scavenging capacity was assessed using DPPH, ABTS, •OH, O2•− methods. The matrix metalloproteinase inhibition potential was measured by collagenase and elastase inhibition tests, using epigallocatechin gallate as a positive control. The extracts exhibited a high scavenging capacity of radical species evaluated and inhibition of diene conjugate formation and thiobarbituric acid reactive substances. The results showed that the crude extracts presented dose-dependent collagenase and elastase inhibition, with IC50 values between 0.04 and 1.61 mg/mL. The structure of the residues of the polysaccharide was identified mainly as (1→3)-sulfated (1→3) α-l-fucopyranose at carbon 4 and residues of β-d-glucopyranose, α-d-Mannopyranose, and β-d-Galactopyranose, while in the polyphenol extract the presence of phloroglucinol was identified and the presence of eckol, bifuhalol, and trifuhalol was suggested. Our results allow us to infer that S. filipendula is a potential source of bioactive ingredients with antioxidant and anti-aging activity. Full article
(This article belongs to the Special Issue Antioxidants for Skin Health)
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Review

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20 pages, 1721 KiB  
Review
Resveratrol and Its Derivatives in Inflammatory Skin Disorders—Atopic Dermatitis and Psoriasis: A Review
by Monika Marko and Rafał Pawliczak
Antioxidants 2023, 12(11), 1954; https://doi.org/10.3390/antiox12111954 - 02 Nov 2023
Cited by 2 | Viewed by 2266
Abstract
Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases whose prevalence has increased worldwide in recent decades. These disorders contribute to patients’ decreased quality of life (QoL) and constitute a socioeconomic burden. New therapeutic options for AD and psoriasis based on natural compounds [...] Read more.
Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases whose prevalence has increased worldwide in recent decades. These disorders contribute to patients’ decreased quality of life (QoL) and constitute a socioeconomic burden. New therapeutic options for AD and psoriasis based on natural compounds are being investigated. These include resveratrol (3,5,40-trihydroxystilbene) and its derivatives, which are produced by many plant species, including grapevines. Resveratrol has gained interest since the term “French Paradox”, which refers to improved cardiovascular outcomes despite a high-fat diet in the French population, was introduced. Resveratrol and its derivatives have demonstrated various health benefits. In addition to anti-cancer, anti-aging, and antibacterial effects, there are also anti-inflammatory and antioxidant effects that can affect the molecular pathways of inflammatory skin disorders. A comprehensive understanding of these mechanisms may help develop new therapies. Numerous in vivo and in vitro studies have been conducted on the therapeutic properties of natural compounds. However, regarding resveratrol and its derivatives in treating AD and psoriasis, there are still many unexplained mechanisms and a need for clinical trials. Considering this, in this review, we discuss and summarize the most critical research on resveratrol and its derivatives in animal and cell models mimicking AD and psoriasis. Full article
(This article belongs to the Special Issue Antioxidants for Skin Health)
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