Redox Regulation in Inflammation and Disease – 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7035

Special Issue Editor

Independent Researcher, Düsseldorf, Germany
Interests: (extracellular) redox regulation; signal transduction; Trx family proteins; cell communication; (neuro-) inflammation; translational immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to be organizing Volume 2 of this Special Issue, entitled “Redox Regulation in Inflammation and Disease”, especially given the success of Volume 1, which you can read here, along with other publications, free of charge:

https://www.mdpi.com/journal/antioxidants/special_issues/Redox_Inflammation__Disease

We distinguish oxidative eu- and distress, acknowledging the role of various factors such as i) the regulated enzymatic production and decay of specific reactive oxygen species (ROS), ii) their role as second messengers, iii) the presence of regulatory thiol switches and their function in redox-mediated signaling.

Specific ROS such as hydrogen peroxide, hydrogen sulfide, and nitric oxide are essential for physiological processes including inflammatory signaling. Redox regulation of membrane proteins, enzymes, and transcription factors such as NFκB is crucial for the activation and migration of immune cells, the production and release of immune mediators, and cell communication. Interestingly, extracellular redox proteins, low-molecular-weight thiols, and thiol switches also affect signal transduction and cell communication. Redox changes can be analyzed in body fluids and isolated immune cell populations without using invasive and expensive techniques, maintaining their potential for developing new preventive and diagnostic tools and innovative treatments.

For this Special Issue, we invite researchers to provide original research articles that report results combining the fields of redox regulation, inflammatory signaling, and translational immunology, highlighting which specific reactive species and/or thiol switches are involved. We also invite the submission of clinical studies demonstrating relevant changes in the levels or activities of i) redox proteins, ii) low-molecular-weight thiols, and/or iii) altered redox states of particular proteins in diseases linked to inflammation. Review articles discussing the current state of the art are also welcome.

Dr. Eva-Maria Hanschmann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox signaling
  • reactive oxygen and nitrogen species
  • inflammation
  • signal transduction
  • thiol switches
  • regulation of immune cells
  • translational immunology

Published Papers (3 papers)

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Research

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18 pages, 1960 KiB  
Article
Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation
by Sara Salman, Cyprien Guermonprez, Laurent Peno-Mazzarino, Elian Lati, Audrey Rousseaud, Lieve Declercq and Saadia Kerdine-Römer
Antioxidants 2023, 12(3), 766; https://doi.org/10.3390/antiox12030766 - 21 Mar 2023
Cited by 5 | Viewed by 2975
Abstract
Photobiomodulation (PBM) is rapidly gaining traction as a valuable tool in dermatology for treating many inflammatory skin conditions using low levels of visible light or near-infrared radiation. However, the physiological regulatory pathways responsible for the anti-inflammatory effect of PBM have not been well [...] Read more.
Photobiomodulation (PBM) is rapidly gaining traction as a valuable tool in dermatology for treating many inflammatory skin conditions using low levels of visible light or near-infrared radiation. However, the physiological regulatory pathways responsible for the anti-inflammatory effect of PBM have not been well defined. Since previous studies showed that nuclear factor-erythroid 2 like 2 (Nrf2) is a master regulator of the skin inflammatory response, we have addressed its role in controlling inflammation by PBM. Primary human keratinocytes (KCs) stimulated with 2,4-dinitrochlorobenzene (DNCB) to mimic pro-inflammatory stress were illuminated with two wavelengths: 660 nm or 520 nm. Both lights significantly reduced the mRNA expression of the DNCB-triggered TNF-α, IL-6, and IL-8 cytokines in KCs, while they enhanced Nrf2 pathway activation. PBM-induced Nrf2 is a key regulator of the inflammatory response in KCs since its absence abolished the regulatory effect of light on cytokines production. Further investigations of the mechanisms contributing to the immunoregulatory effect of PBM in inflamed human skin explants showed that 660 nm light prevented Langerhans cells migration into the dermis, preserving their dendricity, and decreased pro-inflammatory cytokine production compared to the DNCB-treated group. This study is the first to report that the PBM-mediated anti-inflammatory response in KCs is Nrf2-dependent and further support the role of PBM in skin immunomodulation. Therefore, PBM should be considered a promising alternative or complementary therapeutic approach for treating skin-related inflammatory diseases. Full article
(This article belongs to the Special Issue Redox Regulation in Inflammation and Disease – 2nd Edition)
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15 pages, 3231 KiB  
Article
N,N′-Diphenyl-1,4-phenylenediamine Antioxidant’s Potential Role in Enhancing the Pancreatic Antioxidant, Immunomodulatory, and Anti-Apoptotic Therapeutic Capabilities of Adipose-Derived Stem Cells in Type I Diabetic Rats
by Saad Shaaban, Hemdan El-Shamy, Mohamed Gouda, Marwa K. Darwish, Hany M. Abd El-Lateef, Mai M. Khalaf, Ehab I. El-Hallous, Kholoud H. Radwan, Hanan M. Rashwan and Shady G. El-Sawah
Antioxidants 2023, 12(1), 58; https://doi.org/10.3390/antiox12010058 - 27 Dec 2022
Cited by 1 | Viewed by 1418
Abstract
Mesenchymal stem cells (MSCs) are considered to be a promising therapeutic protocol for diabetes mellitus (DM) management. The latter is attributed to their differentiation potentiality to pancreatic β-cells, angiogenesis, and immune-modulatory capabilities by releasing various paracrine factors. Interestingly, antioxidant co-administration increased the MSCs’ [...] Read more.
Mesenchymal stem cells (MSCs) are considered to be a promising therapeutic protocol for diabetes mellitus (DM) management. The latter is attributed to their differentiation potentiality to pancreatic β-cells, angiogenesis, and immune-modulatory capabilities by releasing various paracrine factors. Interestingly, antioxidant co-administration increased the MSCs’ hypoglycemic and regenerative activities. Thus, this study aims to evaluate the therapeutic implication of type 1 DM after the co-administration of adipose tissue-derived-MSCs (AD-MSCs) and N,N′-d iphenyl-1,4-phenylenediamine (DPPD), compared to the single injection of either of them alone. In our four week long experiment, six rat groups were used as control, DPPD (250 mg/kg, i.p.), STZ-diabetic (D), D+DPPD, D+AD-MSCs (1 × 106 cell/rat, i.p.), and D+AD-MSCs+DPPD groups. Within this context, a single injection of AD-MSCs or DPPD into diabetic rats showed significant pancreatic anti-inflammatory, immunomodulation, antioxidant, and anti-apoptotic capacities, superior to AD-MSCs injection. However, AD-MSCs and DPPD co-administration into diabetic rats manifested the highest hypoglycemic and pancreatic regenerative activities in managing diabetes compared to the single shot of AD-MSCs or DPPD. These results highlight the synergetic role of DPPD as an antioxidant in enhancing AD-MSCs’ therapeutic applications. Full article
(This article belongs to the Special Issue Redox Regulation in Inflammation and Disease – 2nd Edition)
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13 pages, 1514 KiB  
Review
Oxidative Stress and Inflammation in B-Cell Lymphomas
by Mário Sousa-Pimenta, Maria Manuela Estevinho, Miguel Sousa Dias, Ângelo Martins and Letícia M. Estevinho
Antioxidants 2023, 12(4), 936; https://doi.org/10.3390/antiox12040936 - 15 Apr 2023
Cited by 3 | Viewed by 2221
Abstract
Mature lymphoid neoplasms arise de novo or by the transformation of more indolent lymphomas in a process that relies on the stepwise accumulation of genomic and transcriptomic alterations. The microenvironment and neoplastic precursor cells are heavily influenced by pro-inflammatory signaling, regulated in part [...] Read more.
Mature lymphoid neoplasms arise de novo or by the transformation of more indolent lymphomas in a process that relies on the stepwise accumulation of genomic and transcriptomic alterations. The microenvironment and neoplastic precursor cells are heavily influenced by pro-inflammatory signaling, regulated in part by oxidative stress and inflammation. Reactive oxygen species (ROSs) are by-products of cellular metabolism able to modulate cell signaling and fate. Moreover, they play a crucial role in the phagocyte system, which is responsible for antigen presentation and the selection of mature B and T cells under normal conditions. Imbalances in pro-oxidant and antioxidant signaling can lead to physiological dysfunction and disease development by disrupting metabolic processes and cell signaling. This narrative review aims to analyze the impact of reactive oxygen species on lymphomagenesis, specifically examining the regulation of microenvironmental players, as well as the response to therapy for B-cell-derived non-Hodgkin lymphomas. Further research is needed to investigate the involvement of ROS and inflammation in the development of lymphomas, which may unravel disease mechanisms and identify innovative therapeutic targets. Full article
(This article belongs to the Special Issue Redox Regulation in Inflammation and Disease – 2nd Edition)
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