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Antioxidants
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Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition
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Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 8510

Special Issue Editors

Prof. Dr. Daniela-Saveta Popa

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Guest Editor
Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania
Interests: polyphenols; antioxidants; anti-aging; phytochemical and drug analysis; food toxicology; in vivo testing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Laurian Vlase

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Guest Editor
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Interests: drug analysis; mass spectrometry; liquid chromatography; pharmacokinetics; biopharmaceutics
Special Issues, Collections and Topics in MDPI journals
Dr. Marius Emil Rusu

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Guest Editor
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania
Interests: bioactive phytochemicals; food chemistry; food science and technology; functional foods; Mediterranean and ketogenic diets; nutraceuticals and functional foods; nutrition and dietetics; nutrition in aging; plant extracts
Special Issues, Collections and Topics in MDPI journals
Dr. Ionel Fizesan

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Guest Editor
Department of Toxicology, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 L. Pasteur Street, 400349 Cluj-Napoca, Romania
Interests: antioxidants; inflammation; cancer; anti-aging; phytochemical and drug analysis; functional foods; in vitro testing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the second volume of our Special Issue "Antioxidants in Age-Related Diseases and Anti-Aging Strategies".

Aging is a complex process based on multiple mechanisms. It is a significant risk factor in the genesis and progression of non-communicable diseases affecting various tissues and systems. As the world's population continues to get older, age-related diseases will become increasingly prevalent. These diseases are the result of reduced cellular activities of protective stress-response pathways, and the accumulation of cellular damage, leading to oxidative stress and inflammaging, major contributors to cellular senescence. Different strategies to slow or reverse these illnesses are needed to postpone aging and increase healthy aging. Plant-origin foods including dark green leafy vegetables, berries and nuts, rich in phytochemical antioxidant molecules, have been revealed to diminish the risk of age-associated syndromes in animal models and humans. Nevertheless, more research is required to further identify specific dietary constituents or other antioxidant molecules, recognize their mechanisms of action and develop new anti-aging strategies.

We cordially invite researchers in the field to contribute original research articles or reviews to this Special Issue of Antioxidants, aiming to identify the roles of antioxidant molecules in preventing age-related diseases and delaying aging, detect the mechanisms of action in preclinical studies or clinical trials, or pinpoint new natural antioxidant sources important for anti-aging strategies.

Prof. Dr. Daniela-Saveta Popa
Prof. Dr. Laurian Vlase
Dr. Marius Emil Rusu
Dr. Ionel Fizesan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • anti-aging strategies
  • healthy aging
  • age-related diseases
  • anti-inflammation
  • mechanisms of action
  • nutrition in aging
  • drugs
  • preclinical and clinical studies
  • bioactive natural compounds

Published Papers (3 papers)

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Research

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20 pages, 6324 KiB  
Article
Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model
by Ion Brinza, Razvan Stefan Boiangiu, Oana Cioanca, Monica Hancianu, Gabriela Dumitru, Lucian Hritcu, Gheorghe-Ciprian Birsan and Elena Todirascu-Ciornea
Antioxidants 2023, 12(8), 1534; https://doi.org/10.3390/antiox12081534 - 31 Jul 2023
Cited by 1 | Viewed by 1654
Abstract
Essential oil from Coriandrum sativum has been demonstrated to provide various pharmacological properties, such as antioxidant, antimicrobial, antibacterial, antifungal, antidiabetic, anticonvulsive, anxiolytic-antidepressant, and anti-aging properties. This study investigated the mechanism of Coriandrum sativum var. microcarpum essential oil (CSEO, 25, 150, and 300 μL/L) [...] Read more.
Essential oil from Coriandrum sativum has been demonstrated to provide various pharmacological properties, such as antioxidant, antimicrobial, antibacterial, antifungal, antidiabetic, anticonvulsive, anxiolytic-antidepressant, and anti-aging properties. This study investigated the mechanism of Coriandrum sativum var. microcarpum essential oil (CSEO, 25, 150, and 300 μL/L) and cognitive impairment and brain oxidative stress in a scopolamine (SCOP, 100 μM) zebrafish model (Danio rerio) of cognitive impairment. Spatial memory, response to novelty, and recognition memory were assessed using the Y-maze test and the novel object recognition test (NOR), while anxiety-like behavior was investigated using the novel tank diving test (NTT). The cholinergic system activity and brain oxidative stress were also evaluated. CSEO was administered to zebrafish once a day for 21 days, while SCOP and galantamine (GAL, 1 mg/L) were delivered 30 min before behavioral testing and euthanasia. Our data revealed that SCOP induced memory dysfunction and anxiety-like behavior, while CSEO improved memory performance, as evidenced by behavioral tasks. Moreover, CSEO attenuated SCOP-induced brain oxidative stress and decreased acetylcholinesterase (AChE) activity. The results demonstrated the potential use of the CSEO in providing beneficial effects by reducing memory deficits and brain oxidative stress involved in the genesis of a dementia state. Full article
(This article belongs to the Special Issue Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition)
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17 pages, 2640 KiB  
Article
Effects of Thyme (Thymus vulgaris L.) Essential Oil on Aging-Induced Brain Inflammation and Blood Telomere Attrition in Chronologically Aged C57BL/6J Mice
by Dwina Juliana Warman, Huijuan Jia and Hisanori Kato
Antioxidants 2023, 12(6), 1178; https://doi.org/10.3390/antiox12061178 - 30 May 2023
Cited by 2 | Viewed by 3746
Abstract
Chronological aging is commonly accompanied by chronic low-grade inflammation (or “inflammaging”), a contributor to the development of age-related chronic diseases. Aging increases oxidative stress that accelerates telomere shortening, leading to cell senescence and the generation of senescence-associated secretory phenotype (SASP) that exacerbates inflammation. [...] Read more.
Chronological aging is commonly accompanied by chronic low-grade inflammation (or “inflammaging”), a contributor to the development of age-related chronic diseases. Aging increases oxidative stress that accelerates telomere shortening, leading to cell senescence and the generation of senescence-associated secretory phenotype (SASP) that exacerbates inflammation. Dietary antioxidants may help protect telomeres and attenuate inflammation. Thyme essential oil (TEO), reported for its potency against neuroinflammation, was fed to chronologically aged C57BL/6J mice for 24 weeks. The TEO diet showed notable impacts on the hippocampus, indicated by lower expression of the aging-related gene p16INK4A (p = 0.0783) and significantly lower expression of cyclin D kinase Cdk4 and Cdk6 (p < 0.05) compared to the age-matched control mice. The TEO group also showed significantly lower gene expression of the pro-inflammatory cytokine Il6 (p < 0.05) in the hippocampus and lower Il1b expression in the liver and cerebellum (p < 0.05). In vitro experiments conducted on NIH-3T3 cells expressing SASP revealed the dose-dependent anti-inflammatory activity of TEO. Remarkably, TEO diet-fed mice showed higher survival rates and significantly longer blood telomere lengths than the control mice. Monoterpene antioxidants in TEO, particularly thymol and p-cymene, may primarily contribute to the anti-inflammatory and telomere-protecting activities of TEO. Full article
(This article belongs to the Special Issue Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition)
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Other

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44 pages, 912 KiB  
Systematic Review
Phytochemicals and Biological Activities of Walnut Septum: A Systematic Review
by Letiția Mateș, Marius Emil Rusu and Daniela-Saveta Popa
Antioxidants 2023, 12(3), 604; https://doi.org/10.3390/antiox12030604 - 01 Mar 2023
Cited by 17 | Viewed by 2559
Abstract
In the last few decades, scientific evidence has stressed the importance of plants in the prevention and/or supportive treatment of a plethora of diseases, many of them chronic, age-associated disorders. Juglans regia L. is a traditional plant that has been integrated into traditional [...] Read more.
In the last few decades, scientific evidence has stressed the importance of plants in the prevention and/or supportive treatment of a plethora of diseases, many of them chronic, age-associated disorders. Juglans regia L. is a traditional plant that has been integrated into traditional medicine since ancient times. Due to the presence of biologically active compounds, walnut was used in the treatment of various maladies. Recently, investigations have focused on the walnut by-products and waste products, with research on their valuable constituents and active properties. Among these secondary products, walnut septum was analyzed in several studies, its phytochemical profile described, and some of the biological activities examined. However, compared to other walnut by-products, no comprehensive review to gather all the pertinent scientific knowledge was found in the literature. Therefore, the aim of this study was to critically assess the information furnished by peer-reviewed articles regarding the walnut septum chemical composition and the related biological activities, including antioxidant activities, anti-inflammatory effects, antimicrobial properties, antidiabetic activities, anti-tumor properties, and anti-aging potential. In conclusion, as these preclinical studies showed that walnut septum metabolites were responsible for a wide range of preventive and therapeutic uses, further research should confirm the beneficial outcomes in clinical trials. Full article
(This article belongs to the Special Issue Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition)
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