Antioxidants in Diabetes and Other Endocrine Disorders

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 256

Special Issue Editors

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Interests: cardiology; heart failure; hypertension; diabetes mellitus; immunology; cell biology
Endocrinology and Metabolism Internal Medicine, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan
Interests: endocrinology; metabolism; diabetes mellitus; functional food

Special Issue Information

Dear Colleagues,

Oxidative stress is widely known to cause various diseases. Non-alcoholic steatohepatitis (NASH), which progresses to liver cirrhosis via fatty liver and is associated with the development of hepatocellular carcinoma, is increasing in prevalence and has become a worldwide problem. Insulin resistance, adipocytokines, apoptosis, autoimmune disease, intestinal bacteria, and genetic polymorphism have been implicated in the pathogenesis of NASH, and oxidative stress is also thought considered to play a major role in its progression. It is highly likely that oxidative stress is deeply involved in the formation of NASH-associated liver lesions, and suppression of oxidative stress is recognized as an important therapeutic strategy in the treatment of NASH. While various drugs are used for the treatment of NASH, a cure has not yet been established. Many functional foods with antioxidant activity have been identified, and some of them have been reported to be effective in suppressing the onset and progression of NASH. Vitamin E is a food constituent that has been shown in meta-analyses and randomized controlled trials (RCTs) to have beneficial effects on NASH. Although no meta-analyses or RCTs demonstrating efficacy have been reported, foods and ingredients that can be expected to inhibit the progression of NASH via antioxidant activity include n-3 fatty acids, curcumin, sulforaphane, mushrooms, resveratrol, sake lees, and activated charcoal. Although there are many ingredients and foods with antioxidant activity, few meta-analyses and RCTs have demonstrated their efficacy in inhibiting the progression of NASH. Thus, we are not yet at the stage where we can reliably expect to attenuate the progression of NASH solely through daily consumption of antioxidant-rich foods.

Prof. Dr. Kenichi Watanabe
Dr. Hiroshi Suzuki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • diabetic cardiomyopathy
  • diabetes mellitus
  • diabetic nephropathy
  • functional food
  • NASH

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop