Potential Benefits of Antioxidant Phytochemicals on Endogenous Antioxidants Defences in Chronic Diseases—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 273

Special Issue Editors

Department of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy
Interests: oxidative stress and gene expression of antioxidant signaling pathways in chronic
Special Issues, Collections and Topics in MDPI journals
Department of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy
Interests: oxidative stress in physiopathology and therapy of atherosclerosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our previous Special Issue, “Potential Benefits of Antioxidant Phytochemicals on Endogenous Antioxidants Defences in Chronic Diseases” (https://www.mdpi.com/journal/antioxidants/special_issues/Phytochemicals_Chronic), published in the 2022 volume of Antioxidants, received an overwhelming number of submissions and was a successful compilation of research and review articles. As this is a rapidly evolving topic, we would like to further explore the role of antioxidant phytochemicals in chronic diseases with a follow-up Special Issue in 2024.

Epidemiological evidence clearly shows that the antioxidant phytochemicals contained in many fruits and vegetables have healthy beneficial effects and may reduce the risk of chronic degenerative diseases related to oxidative stress and cancer. These protective effects have mainly been attributed to polyphenols, which are plant secondary metabolites omnipresent in many parts of plants. Several in vitro studies have demonstrated that polyphenols, the most abundant antioxidants in our diet, can work as antioxidants since they have an electron-donating phenolic group in their structure. Although their antioxidant function has long been indicated to be pivotal in promoting their health benefits, several studies have demonstrated that many antioxidants in food provide cellular and tissue protection against oxidative damage by inducing endogenous antioxidant defenses, particularly transcription factors such as Nrf2 and kinases involved in signal transduction pathways. In spite of the fact a number of studies have demonstrated a relationship between polyphenol consumption and a decrease in risk factors for chronic diseases, disagreement in elucidating their effects has been found when bioavailability is considered. As a matter of fact, it has been shown that polyphenols have a poor bioavailability, and that their biological action may be mediated by their metabolites, which have antioxidant and anti-inflammatory resources.

Contributions to this Special Issue may cover all research aspects related, but not limited, to studies (on humans, on animal models and in vitro) evaluating the following:

  • Beneficial effects of polyphenols for chronic diseases such as cardiovascular and neurodegenerative diseases, diabetes, osteoporosis and some cancers;
  • Mechanisms of action of polyphenols as antioxidants;
  • Mechanisms of action of polyphenols and, in particular, of the different components on signal transduction pathways;
  • Potential anti-inflammatory mechanisms of polyphenols in chronic diseases;
  • Bioavailability of the different classes of polyphenols;
  • Active metabolites of polyphenols.

Prof. Dr. Anna Maria Fratta Pasini
Prof. Dr. Luciano Cominacini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • chronic diseases
  • oxidative stress
  • antioxidants
  • signal transduction
  • bioavailability
  • inflammation
  • cardiovascular diseases
  • cancer
  • neurodegenerative diseases

Published Papers

There is no accepted submissions to this special issue at this moment.
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