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Antioxidants
Special Issues
Oxidative Stress and Antioxidants in Nutrition, Exercise and Toxicology/Pharmacology
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Oxidative Stress and Antioxidants in Nutrition, Exercise and Toxicology/Pharmacology

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 5303

Special Issue Editors

Dr. Aristidis S. Veskoukis

E-Mail Website
Guest Editor
Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Argonafton 1, 42132 Trikala, Greece
Interests: oxidative stress; free radicals; redox biomarkers; redox nutrition; antioxidant supplementation; polyphenols; exercise; redox toxicology; redox biology
Special Issues, Collections and Topics in MDPI journals
Dr. Christonikos Leventelis

E-Mail Website
Guest Editor
1. Greek Organization against Drugs, Athens, Greece
2. Research and Academic Associate, University of Peloponnese, Tripoli, Greece
Interests: toxicology; inflammation; oxidative stress

Special Issue Information

Dear Colleagues,

Nutrition, exercise and the administration/consumption of xenobiotics (i.e., food preservatives, food additives, medicinal compounds and drugs) are stimuli able to modify blood and tissue redox homeostasis. Free-radical generation and the enhancement of the internal antioxidant arsenal of humans and animal models are two putative and conflicting biochemical and molecular outcomes in the redox continuum that are attributed to such treatments. The measurement of oxidative stress using specific redox biomarkers is a common practice in order to characterize redox-altering stimuli as antioxidant or prooxidant. Based on the above, researchers are invited to submit original or review/opinion articles that present the current knowledge regarding both the beneficial and noxious roles of nutrition, exercise and toxicological/pharmacological treatments on blood and tissue redox homeostasis, as well as the characterization of plant-based compounds as antioxidant agents in vitro.

This Special Issue welcomes submissions concerning several research areas that, among others, include:

  • The role of nutritional interventions (i.e., administration of physical or chemical compounds) in blood and tissue redox status;
  • The role of exercise (i.e., acute or training protocols) on the oxidative stress profile of biological fluids and tissues;
  • The potential ability of chemical compounds present in foods (i.e., food preservatives and food additives) to alter blood and tissue redox homeostasis;
  • The effects of medicinal compounds and drugs on human and animal antioxidant profile;
  • Redox biomarkers as biochemical and molecular tools of high translational value;
  • The role of oxidative stress, measured through established redox biomarkers, in nutrition, exercise and toxicology/pharmacology;
  • The characterization of plant-based and chemical compounds as putative anti- or prooxidant agents using in vitro methods.

Dr. Aristidis S. Veskoukis
Dr. Christonikos Leventelis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • redox biomarkers
  • nutrition
  • exercise
  • antioxidants
  • plant extracts
  • drugs
  • medicinal compounds
  • food toxicity

Published Papers (3 papers)

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Research

13 pages, 2251 KiB  
Article
The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats
by Renáta Szabó, Denise Börzsei, Alexandra Hoffmann, Viktória Kiss, András Nagy, Szilvia Török, Médea Veszelka, Nikoletta Almási and Csaba Varga
Antioxidants 2023, 12(7), 1450; https://doi.org/10.3390/antiox12071450 - 19 Jul 2023
Viewed by 1102
Abstract
Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim [...] Read more.
Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim was to focus on lifestyle-induced (type of diet and physical exercise) effects on adipokine profile and lipid peroxidation in SHRSP rats. In our study, male Wistar-kyoto (control) and SHRSP rats were used. SHRSP rats were fed either standard chow or a high-fat diet with 40% fat content (HFD). One group of the animals was placed into cages fitted with a running-wheel; thus, the dietary and training period started at the same time and lasted for 12 weeks. At the end of the experimental period, adiponectin, leptin, omentin, and chemerin concentrations were determined from adipose tissue and serum. Besides adipokines, malondialdehyde (MDA) levels were also measured. Twelve weeks of HFD significantly decreased adiponectin and omentin concentrations of both adipose tissue and serum, which were ameliorated by physical exercise. Serum leptin, chemerin, and MDA values were elevated in HFD groups; however, physical exercise was able to mitigate these adverse changes. Our results underpin the crosstalk between lifestyle changes and dysfunctional adipose tissue in SHRSP rats. Full article
(This article belongs to the Special Issue Oxidative Stress and Antioxidants in Nutrition, Exercise and Toxicology/Pharmacology)
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20 pages, 14015 KiB  
Article
Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage
by Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K. Nüssler, Liegang Liu and Wei Yang
Antioxidants 2023, 12(3), 588; https://doi.org/10.3390/antiox12030588 - 27 Feb 2023
Cited by 3 | Viewed by 2049
Abstract
Deoxynivalenol (DON) is a kind of Fusarium toxin that can cause a variety of toxic effects. DON is mainly metabolized and detoxified by the liver. When the concentration of DON exceeds the metabolic capacity of the liver, it will trigger acute or chronic [...] Read more.
Deoxynivalenol (DON) is a kind of Fusarium toxin that can cause a variety of toxic effects. DON is mainly metabolized and detoxified by the liver. When the concentration of DON exceeds the metabolic capacity of the liver, it will trigger acute or chronic damage to the liver tissue. Previous studies demonstrated that bone marrow mesenchymal stem-cell-secreted exosomes (BMSC-exos) reduce liver injury. Therefore, we issue a hypothesis that in vitro-cultured rat BMSC-secreted exos could ameliorate liver damage after 2 mg/kg bw/day of DON exposure. In total, 144 lipids were identified in BMEC-exos, including high polyunsaturated fatty acid (PUFA) levels. BMSC-exos treatment alleviated liver pathological changes and decreased levels of alanine aminotransferase, aspartate aminotransferase, inflammatory factors interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and lipid peroxidation. Otherwise, low or high BMSC-exos treatment obviously changes DON-induced hepatic oxylipin patterns. According to the results from our correlation network analysis, Pearson correlation coefficient analysis, and hierarchical clustering analysis, the top 10% oxidized lipids can be classified into two categories: one that was positively correlated with copper–zinc superoxide dismutase (Cu/Zn SOD) and another that was positively correlated with liver injury indicators. Altogether, BMSC-exos administration maintained normal liver function and reduced oxidative damage in liver tissue. Moreover, it could also significantly change the oxylipin profiles under DON conditions. Full article
(This article belongs to the Special Issue Oxidative Stress and Antioxidants in Nutrition, Exercise and Toxicology/Pharmacology)
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22 pages, 3758 KiB  
Article
Comparative Analysis of the Antioxidant, Antidiabetic, Antibacterial, Cytoprotective Potential and Metabolite Profile of Two Endophytic Penicillium spp.
by Kumar Vishven Naveen, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan and Myeong-Hyeon Wang
Antioxidants 2023, 12(2), 248; https://doi.org/10.3390/antiox12020248 - 22 Jan 2023
Cited by 7 | Viewed by 1741
Abstract
The current study assessed the metabolite abundance, alpha (α)-amylase and α-glucosidase inhibitory, antioxidant, and antibacterial activity of the ethyl acetate extract (EAE) of endophytic Penicillium lanosum (PL) and Penicillium radiatolobatum (PR). A higher extract yield was found in EAE-PR with a total phenolic [...] Read more.
The current study assessed the metabolite abundance, alpha (α)-amylase and α-glucosidase inhibitory, antioxidant, and antibacterial activity of the ethyl acetate extract (EAE) of endophytic Penicillium lanosum (PL) and Penicillium radiatolobatum (PR). A higher extract yield was found in EAE-PR with a total phenolic content of 119.87 ± 3.74 mg of GAE/g DW and a total flavonoid content of 16.26 ± 1.95 mg of QE/g DW. The EAE-PR inhibited α-amylase and scavenged ABTS+ radicals with a half-maximal inhibitory concentration (IC50) of 362.5 and 37.5 µg/mL, respectively. Compared with EAE-PL, EAE-PR exhibited higher antibacterial activity against Gram-positive and Gram-negative pathogens. Treatment with EAE-PR (1000 µg/mL) did not cause significant toxicity in the HEK-293 cell line compared to the control cells (p < 0.05). EAE-PR treatments (250–1000 µg/mL) showed higher cytoprotective effects toward H2O2-stressed HEK-293 cells compared with ascorbic acid (AA). The UHPLC-Q-TOF-MS/MS analysis revealed the presence of thiophene A (C13H8S), limonene (C10H16), and phenylacetic acid (C8H8O2) in EAE-PR. Furthermore, these compounds demonstrated substantial interactions with diabetes (α-amylase and α-glucosidase), oxidative stress (NADPH-oxidase), and bacteria (D-alanine D-alanine ligase)-related enzymes/proteins evidenced in silico molecular docking analysis. Full article
(This article belongs to the Special Issue Oxidative Stress and Antioxidants in Nutrition, Exercise and Toxicology/Pharmacology)
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