Bioaccessible and Bioavailable Natural Bioactive Compounds for the Management of Metabolic Syndrome

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 2598

Special Issue Editors

Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja S/N, 18012 Granada, Spain
Interests: antioxidant capacity; personalized nutrition; gut microbiota; chemical browning; diet
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutraceuticals; polyphenols; food chemistry; chromatography; mass spectrometry; food science
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutrition; metabolic diseases; nutraceuticals; polyphenols; in vitro enzymatic assays; cell line culture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a collection of cardiometabolic risk factors that include obesity, insulin-resistance, hypertension, and dyslipidemia. This condition is often associated with an increased risk of developing diabetes and cardiovascular disease, and it is also characterized by increased oxidative stress and chronic inflammatory processes.

In recent decades, the use of natural compounds for the treatment and prevention of metabolic disorders has attracted the general attention of the scientific community because of their potential biological efficacy and low or no side effects.

However, the bioactivity of many natural compounds is closely related to their bioaccessibility through the gastrointestinal tract and consequently their bioavailability through the systemic circulation to the target tissues where they can exert their biological effects. The bioavailability of many compounds is generally low, and the metabolic pathways, as well as the mechanisms of action responsible for their biological activities, are often still unknown. In addition, other factors appear to further influence the bioactivity of natural compounds, such as the qualitative and quantitative composition of the matrix in which they occur (in terms of synergism and/or antagonism effects), their structure, and the metabolic processes mediated by the gut, microbiota and liver.

In this Special Issue, we invite researchers to submit original research articles or review papers addressing the potential effect of bioaccessible and bioavailable bioactive molecules, occurring in the food matrixes, on metabolic syndrome and its related disorders. We are pleased to invite research papers dealing with studies on in vitro or in vivo models and clinical trials with the main objective of expanding knowledge in this field and gaining new insights.

Prof. Dr. José Ángel Rufián-Henares
Dr. Fortuna Iannuzzo
Dr. Maria Maisto
Dr. Elisabetta Schiano
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural bioactive compound
  • oxidative stress
  • inflammation
  • metabolic syndrome
  • bioaccessibility
  • bioavailability
  • metabolization
  • food matrix

Published Papers (1 paper)

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Review

27 pages, 3112 KiB  
Review
Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds
Antioxidants 2023, 12(10), 1894; https://doi.org/10.3390/antiox12101894 - 23 Oct 2023
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Abstract
Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pregnancy. Therefore, an equilibrium between a necessary/pathologic [...] Read more.
Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pregnancy. Therefore, an equilibrium between a necessary/pathologic level of inflammation and oxidative stress during pregnancy is needed to avoid disease development. High-density lipoproteins (HDL) are important for a healthy pregnancy and a good neonatal outcome. Their role in fetal development during challenging situations is vital for maintaining the equilibrium. However, in certain conditions, such as obesity, diabetes, and other cardiovascular diseases, it has been observed that HDL loses its protective properties, becoming dysfunctional. Bioactive compounds have been widely studied as mediators of inflammation and oxidative stress in different diseases, but their mechanisms of action are still unknown. Nonetheless, these agents, which are obtained from functional foods, increase the concentration of HDL, TRC, and antioxidant activity. Therefore, this review first summarizes several mechanisms of HDL participation in the equilibrium between inflammation and oxidative stress. Second, it gives an insight into how HDL may act as a vector for bioactive compounds. Third, it describes the relationships between the inflammation process in pregnancy and HDL activity. Consequently, different databases were used, including MEDLINE, PubMed, and Scopus, where scientific articles published in the English language up to 2023 were identified. Full article
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