Special Issue "Disentangling the Association between Chronic Diseases and Oxidative Stress through Metabolomics"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Methods for Antioxidants Evaluation/Measurement".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 940

Special Issue Editor

Department of Pathology, Medicine and Odontology Faculty, University of Valencia, 46010 Valencia, Spain
Interests: tumor metabolism for precision medicine in cancer; healthy aging; frailty and metabolic age; host- microbiota co-metabolism influence on health; cardiometabolic and cardiovascular disease; biophysical characterization of lipoproteins particles in plasma using NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress is the result of metabolic disbalance and can impact all components of the cell, including DNA, proteins, and metabolites. Many studies suggest an essential role of oxidative stress in the pathogenesis of chronic diseases, including cardiovascular diseases, diabetes, and neurodegenerative diseases. Studies analyzing the metabolic impact of oxidative stress on experimental models or human cohorts are scarce. Metabolomics provides information on a wide range of molecular processes through the measurement of individual metabolites. Metabolomics stands at the end of the -omic cascade (from genomics, transcriptomics, and proteomics to metabolomics), and changes in the metabolome represent the last response to genetic, chemical, and environmental alterations. As a consequence, the metabolome is closely linked to the phenotype and constitutes an important tool for detecting and understanding physiological and pathophysiological states. The goal of this Special Issue is to collect evidence and provide mechanistic insight to better understand the association between oxidative stress and chronic diseases through the analysis of metabolites.

Dr. Daniel Monleon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • oxidative stress
  • metabolomics
  • chronic diseases
  • cardiovascular disease
  • diabetes
  • neurodegenerative diseases

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


18 pages, 7246 KiB  
Altered Lipid Moieties and Carbonyls in a Wistar Rat Dietary Model of Subclinical Fatty Liver: Potential Sex-Specific Biomarkers of Early Fatty Liver Disease?
Antioxidants 2023, 12(10), 1808; https://doi.org/10.3390/antiox12101808 - 28 Sep 2023
Cited by 1 | Viewed by 487
Non-alcoholic fatty liver disease (NAFLD) is a condition in which excess fat builds up in the liver. To date, there is a lack of knowledge about the subtype of lipid structures affected in the early stages of NAFLD. The aim of this study [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is a condition in which excess fat builds up in the liver. To date, there is a lack of knowledge about the subtype of lipid structures affected in the early stages of NAFLD. The aim of this study was to analyze serum and liver lipid moieties, specifically unsaturations and carbonyls, by nuclear magnetic resonance (NMR) in a subclinical Wistar rat model of NAFLD for detecting early alterations and potential sex dimorphisms. Twelve weeks of a high-fat diet (HFD) induced fat accumulation in the liver to a similar extent in male and female Wistar rats. In addition to total liver fat accumulation, Wistar rats showed a shift in lipid subtype composition. HFD rats displayed increased lipid carbonyls in both liver and serum, and decreased in unsaturated fatty acids (UFAs) and polyunsaturated fatty acids (PUFAs), with a much stronger effect in male than female animals. Our results revealed that the change in fat was not only quantitative but also qualitative, with dramatic shifts in relevant lipid structures. Finally, we compared the results found in Wistar rats with an analysis in a human patient cohort of extreme obesity. For the first time to our knowledge, lipid carbonyl levels and lipoproteins profiles were analyzed in the context of subclinical NAFLD. The association found between lipid carbonyls and alanine aminotransferase (ALT) in a human cohort of extremely obese individuals further supports the potential role of lipid moieties as biomarkers of early NAFLD. Full article
Show Figures

Figure 1

Back to TopTop